Antibacterial Behavior of Oxygen-Generating Nanomaterial for Medical Applications Publisher



Faraji M ; Mohammadzadeh F ; Sanjabi K ; Saraei M ; Gholipourmalekabadi M
Source: Journal of Applied Biotechnology Reports Published:2026

Abstract

There are significant challenges for the development of an efficient antibacterial agent for the prevention or treatment of post-surgical infections, especially with synthetic scaffolds for surgical implants. This problem has been further exacerbated by the extensive use of antibiotics in healthcare settings, which has led to an increased incidence of multidrug-resistant bacteria. Despite several successes in the development of novel antibacterial agents, there are ongoing efforts to find effective and safe antibacterial agents. Recently, the development of oxygen-generating nanomaterials has been proposed as a possible choice for antibacterial materials. The preliminary investigation demonstrated that such materials could exhibit strong antibacterial activity, minimize postsurgery-induced hypoxia, and prevent infections. Regenerative medicine is a multibillion-dollar industry, and the lack of suitable materials as 3D scaffolds has hindered its application in clinical settings. A critical review of the different kinds of oxygen-generating reagents, as well as their mechanisms of oxygen release and antimicrobial potential, is presented, following an appraisal of the literature. © 2026 The Author(s).