Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders

Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders Publisher Pubmed

Sheykhisabzehpoush M¹ ; Ghasemian M² ; Khojasteh Pour F³ ; Mighani M⁴ ; Moghanibashi M⁵ ; Mohammad Jafari R⁶ ; Zabel M^{7, 8} ; Dziegiel P⁸ ; Farzaneh M⁶ ; Kempisty B^{9, 10, 11}

Show Affiliations

1. Department of Laboratory, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Department of Obstetrics and Gynecology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4. School of Medicine, Golestan University of Medical Sciences, Golestan, Iran
5. Department of Genetics, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran
6. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7. Division of Anatomy and Histology, University of Zielona Gora, Zielona Gora, 65-046, Poland
8. Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, 50-368, Poland
9. Department of Human Morphology and Embryology, Division of Anatomy, Wroclaw Medical, University, Wroclaw, Poland
10. Institute of Veterinary Medicine, Department of Veterinary Surgery, Nicolaus Copernicus University, Torun, Poland
11. North Carolina State University College of Agriculture and Life Sciences, Raleigh, 27695, NC, United States

Source: Clinical and Translational Oncology Published:2023

Abstract

Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to xist) is an evolutionarily conserved lncRNA that is located upstream of XIST and regulates its expression. FTX participates in progression of various malignancy including gastric cancer, glioma, ovarian cancer, pancreatic cancer, and retinoblastoma. Also, FTX can be involved in the pathogenesis of non-cancerous disorders such as endometriosis and stroke. FTX acts as competitive endogenous RNA (ceRNA) and via sponging various miRNAs, including miR-186, miR-200a-3p, miR-215-3p, and miR-153-3p to regulate the expression of their downstream target. FTX by targeting various signaling pathways including Wnt/β-catenin, PI3K/Akt, SOX4, PDK1/PKB/GSK-3β, TGF-β1, FOXA2, and PPARγ regulate molecular mechanism involved in various disorders. Dysregulation of FTX is associated with an increased risk of various disorders. Therefore, FTX and its downstream targets may be suitable biomarkers for the diagnosis and treatment of human malignancies. In this review, we summarized the emerging roles of FTX in human cancerous and non-cancerous cells. © 2023, The Author(s), under exclusive licence to Federacion de Sociedades Espanolas de Oncologia (FESEO).

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5. A Comprehensive Review of the Role of Lncrnas in Gastric Cancer (Gc) Pathogenesis, Immune Regulation, and Their Clinical Applications, Pathology Research and Practice (2023)

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Style	Citing Format
MLA	Sheykhisabzehpoush M, et al.. "Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders." Clinical and Translational Oncology, vol. 25, no. 10, 2023, pp. 2812-2831.
APA	Sheykhisabzehpoush M, Ghasemian M, Khojasteh Pour F, Mighani M, Moghanibashi M, Mohammad Jafari R, Zabel M, Dziegiel P, Farzaneh M, Kempisty B (2023). Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders. Clinical and Translational Oncology, 25(10), 2812-2831.
Chicago	Sheykhisabzehpoush M, Ghasemian M, Khojasteh Pour F, Mighani M, Moghanibashi M, Mohammad Jafari R, Zabel M, Dziegiel P, Farzaneh M, Kempisty B. "Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders." Clinical and Translational Oncology 25, no. 10 (2023): 2812-2831.
Harvard	Sheykhisabzehpoush M et al. (2023) 'Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders', Clinical and Translational Oncology, 25(10), pp. 2812-2831.
Vancouver	Sheykhisabzehpoush M, Ghasemian M, Khojasteh Pour F, Mighani M, Moghanibashi M, Mohammad Jafari R, et al.. Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders. Clinical and Translational Oncology. 2023;25(10):2812-2831.
BibTex	@article{ author = {Sheykhisabzehpoush M and Ghasemian M and Khojasteh Pour F and Mighani M and Moghanibashi M and Mohammad Jafari R and Zabel M and Dziegiel P and Farzaneh M and Kempisty B}, title = {Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders}, journal = {Clinical and Translational Oncology}, volume = {25}, number = {10}, pages = {2812-2831}, year = {2023} }
RIS	TY - JOUR AU - Sheykhisabzehpoush M AU - Ghasemian M AU - Khojasteh Pour F AU - Mighani M AU - Moghanibashi M AU - Mohammad Jafari R AU - Zabel M AU - Dziegiel P AU - Farzaneh M AU - Kempisty B TI - Emerging Roles of Long Non-Coding Rna Ftx in Human Disorders JO - Clinical and Translational Oncology VL - 25 IS - 10 SP - 2812 EP - 2831 PY - 2023 ER -

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