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Efficient One Pot Synthesis of Phenylimidazo[1,2-A]Pyridine Derivatives Using Multifunctional Copper Catalyst Supported on Β-Cyclodextrin Functionalized Magnetic Graphene Oxide Publisher



Bahadorikhalili S1 ; Malek K2 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. School of Chemistry, College of Science, University of Tehran, 14155-6455, Tehran, Iran
  2. 2. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Applied Organometallic Chemistry Published:2020


Abstract

In this paper, a novel, “green”, efficient and atom-economical methodology for the synthesis of N-(alkyl)-2-phenylimidazo[1,2-a]pyridin-3-amine derivatives based on copper catalyzed oxidative cyclization is presented. An efficient copper nanocatalyst was fabricated by immobilization of Cu on β-Cyclodextrin (βCD) functionalized magnetic graphene oxide nanosheets (denoted as Cu@βCD@MGO). This catalyst primarily oxidizes benzylic alcohols to aldehydes by aerobic O2. The obtained aldehydes, in situ, takes part in a three component reaction with pyridin-2-amine and isocyanides to produce corresponding N-(alkyl)-2-phenylimidazo[1,2-a]pyridin-3-amine derivatives. The catalyst was characterized by TEM, SEM, VSM, FT-IR, XRD, TGA and ICP. As an advantage, the catalyst showed to be highly recoverable and no appreciable leaching was observed after 10 runs. © 2020 John Wiley & Sons, Ltd.