Effect of Green Coffee Supplementation on Androgens Level in Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial Publisher



Mousavi A¹ ; Saedisomeolia A^{1, 2} ; Yekaninejad M³ ; Ildarabadi A¹ ; Meshkani M¹ ; Vahiddastjerdi M⁴ Show Affiliations
Source: Obesity Medicine Published:2020

Abstract

The present study was aimed at determining the effect of green coffee supplementation on androgens level in women with Poly-Cystic Ovary Syndrome (PCOS) through double-blind Randomized Clinical Trial (RCT). Each patient (n = 17) in the treatment group received one green coffee capsule (400 mg) and the control group (n = 17) received one placebo for six weeks. Then, the levels of free testosterone, dihydrotestosterone, and androstenedione; lipid profile; glycemia and insulinemia indices; and anthropometric indices before and after the intervention were determined and compared. The results showed green coffee supplements reduced testosterone level (P = 0.038). There was no significant difference in general characteristics of the participants, including education, occupational status, age of illness, and metformin usage. At the beginning and the end of the study, there was a significant decrease in triglyceride (P = 0.007) and total cholesterol level (P = 0.035) in the green coffee group in comparison with the placebo group. However, no significant difference in anthropometric data including weight, Body Mass Index (BMI), waist circumference, and waist-to-hip ratio was observed. Moreover, no significant difference was observed in fasting blood glucose, insulin levels, insulin resistance index, LDL, HDL, dihydrotestosterone, and androstenedione. The results of the clinical trial showed that supplementation of 400 mg green coffee a day for six weeks significantly reduced free testosterone, triglyceride, and cholesterol levels. Therefore, green coffee might help to improve Poly-Cystic Ovary Syndrome (PCOS). © 2020 Elsevier Ltd