The Effect of Green Coffee Extract Supplementation on Cardio Metabolic Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Publisher



Morvaridi M¹ ; Rayyani E² ; Jaafari M² ; Khiabani A³ ; Rahimlou M⁴
Source: Journal of Diabetes and Metabolic Disorders Published:2020

Abstract

Purpose: Considering the present controversies on the association between green coffee supplementation and cardio metabolic risk factors, this systematic review and meta-analysis was conducted to evaluate the effect of green coffee supplementation on cardio metabolic risk factors. Method: A systematic literature search was performed throughout the PubMed, Embase, Scopus, and Web of Science databases up to October 2019. As a result, all randomized controlled trials over the effect of green coffee supplementation on fasting blood sugar (FBS), insulin, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), C - reactive protein (CRP), and homeostatic model assessment for insulin resistance (HOMA-IR) in adults were examined. Data were extracted from the relevant studies and analyzed using the random-effect or pooled model and standardized mean difference (SMD) with 95% confidence interval (CI). Results: After excluding the irrelevant articles, 27 studies were included in the final analysis. Pooled results revealed that green coffee supplementation significantly reduced FBS (WMD = −2.28, 95% CI: −4.49 to −0.07, P = 0.043), insulin (WMD = −0.53, 95% CI: −0.93 to −0.14, P = 0.008), and triglyceride (WMD = −9.28, 95% CI: −14.93 to - 3.63, P = 0.001). Furthermore, green coffee supplementation increased the HDL levels (WMD = 1.33, 95% CI: 0.08 to 2.58, P = 0.037). However, the changes in HOMA-IR, LDL, and CRP levels were not significant (P > 0.05). Conclusion: This meta-analysis indicated that green coffee supplementation significantly decreased FBS, insulin, and triglyceride, but improved HDL. No statistically significant improvement was found in HOMA-IR, LDL, and CRP indices following the green coffee supplementation. © 2020, Springer Nature Switzerland AG.