Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Harnessing the Cancer Radiation Therapy by Lanthanide-Doped Zinc Oxide Based Theranostic Nanoparticles Publisher Pubmed



Ghaemi B1 ; Mashinchian O1, 4 ; Mousavi T5 ; Karimi R2 ; Kharrazi S1 ; Amani A1, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Tissue Engineering, SATiM, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland
  5. 5. Department of Materials, University of Oxford, Oxford, OX1 3PH, United Kingdom

Source: ACS Applied Materials and Interfaces Published:2016


Abstract

In this paper, doping of europium (Eu) and gadolinium (Gd) as high-Z elements into zinc oxide (ZnO) nanoparticles (NPs) was designed to optimize restricted energy absorption from a conventional radiation therapy by X-ray. Gd/Eu-doped ZnO NPs with a size of 9 nm were synthesized by a chemical precipitation method. The cytotoxic effects of Eu/Gd-doped ZnO NPs were determined using MTT assay in L929, HeLa, and PC3 cell lines under dark conditions as well as exposure to ultraviolet, X-ray, and γ radiation. Doped NPs at 20 μg/mL concentration under an X-ray dose of 2 Gy were as efficient as 6 Gy X-ray radiation on untreated cells. It is thus suggested that the doped NPs may be used as photoinducers to increase the efficacy of X-rays within the cells, consequently, cancer cell death. The doped NPs also could reduce the received dose by normal cells around the tumor. Additionally, we evaluated the diagnostic efficacy of doped NPs as CT/MRI nanoprobes. Results showed an efficient theranostic nanoparticulate system for simultaneous CT/MR imaging and cancer treatment. © 2016 American Chemical Society.
Related Docs
View other Related Docs
1. Intracellular Ros Induction by Ag@Zno Core-Shell Nanoparticles: Frontiers of Permanent Optically Active Holes in Breast Cancer Theranostic, ACS Applied Materials and Interfaces (2018)
2. Enhanced Cytotoxic and Genotoxic Effects of Gadolinium-Doped Zno Nanoparticles on Irradiated Lung Cancer Cells at Megavoltage Radiation Energies, Materials Science and Engineering C (2019)
3. Necrotic, Apoptotic and Autophagic Cell Fates Triggered by Nanoparticles, Autophagy (2019)
4. Investigating the Therapeutic Effect of Folic Acid Conjugated Zno Nanoparticles on Human Triple Negative Breast Cancer Cell Line; [Istrazivanje Terapeutskog Efekta Nanocestica Zno Konjugovanih Sa Folnom Kiselinom Na Trostruko Negativnu Celijsku Liniju Raka Dojke Kod Ljudi], Materials Protection (2023)
5. The Role and Mechanisms of Zinc Oxide Nanoparticles in the Improvement of the Radiosensitivity of Lung Cancer Cells in Clinically Relevant Megavoltage Radiation Energies In-Vitro, Nanomedicine Journal (2019)
6. Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology, Nano Biomedicine and Engineering (2016)
7. Application of New Zno Nanoformulation and Ag/Fe/Zno Nanocomposites As Water-Based Nanofluids to Consider in Vitro Cytotoxic Effects Against Mcf-7 Breast Cancer Cells, Artificial Cells# Nanomedicine and Biotechnology (2017)
8. Process-Dependent Photocatalytic Performance of Quantum Sized Zno Nanoparticles, Materials Research Express (2018)
Experts (# of related papers)
View all Related Experts
Sharmin Kharrazi (5)
Saeid Sarkar (3)
Other Related Docs
9. Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity, Nanomaterials (2018)
10. Chitosan Coated Tungsten Trioxide Nanoparticles As a Contrast Agent for X-Ray Computed Tomography, International Journal of Biological Macromolecules (2017)
11. Evaluation of Size, Morphology, Concentration, and Surface Effect of Gold Nanoparticles on X-Ray Attenuation in Computed Tomography, Physica Medica (2018)
12. X-Ray-Based Cancer Diagnosis and Treatment Methods, Electromagnetic Waves-Based Cancer Diagnosis and Therapy: Principles and Applications of Nanomaterials (2023)
13. Dual-Energy Ct Imaging of Nasopharyngeal Cancer Cells Using Multifunctional Gold Nanoparticles, IET Nanobiotechnology (2019)
14. Evaluating the Effect of Zinc Oxide Nanoparticles Doped With Gadolinium on Dose Enhancement Factor by Presage Dosimeter, International Journal of Radiation Research (2016)
15. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
16. A Nanotechnology-Based Strategy to Increase the Efficiency of Cancer Diagnosis and Therapy: Folate-Conjugated Gold Nanoparticles, Current Medicinal Chemistry (2017)
17. Emerging Role of Nanotechnology in Treatment of Non-Alcoholic Fatty Liver Disease (Nafld), EXCLI Journal (2023)
18. Solid Silica Nanoparticles: Applications in Molecular Imaging, Contrast Media and Molecular Imaging (2015)
19. Nadph Oxidase As a Target for Modulation of Radiation Response; Implications to Carcinogenesis and Radiotherapy, Current Molecular Pharmacology (2019)
20. Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes, Iranian Journal of Pharmaceutical Research (2018)
21. Functionalization of Zno Nanoparticles by 3-Mercaptopropionic Acid for Aqueous Curcumin Delivery: Synthesis, Characterization, and Anticancer Assessment, Materials Science and Engineering C (2017)