Application of New Zno Nanoformulation and Ag/Fe/Zno Nanocomposites As Water-Based Nanofluids to Consider in Vitro Cytotoxic Effects Against Mcf-7 Breast Cancer Cells Publisher Pubmed



Abdolmohammadi MH¹ ; Fallahian F¹ ; Fakhroueian Z² ; Kamalian M³ ; Keyhanvar P^{4, 5} ; M Harsini F⁶ ; Shafiekhani A^{7, 8} Show Affiliations
Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017

Abstract

Novel formulations of nanocomposites derived from ZnO nanoparticles have provided potential biomedical applications as a new strategy for treatment of breast cancer. In this research, two types of ZnO nanomaterials were synthesized by sol–gel hydrothermal process and co-precipitation containing fast quenching and also surface modification methods. The cytotoxic effects on growth of the breast cancer cell lines MCF-7 were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cell viability of the breast cancer cell line MCF-7 was reduced with increasing ZnO nanofluid concentrations at 48 and 72 h of treatment. The IC50 value of MCF-7 cells after 72 h of treatment with the first product ZnO (a) and second one ZnO (c) were measured as 51.02 and 48.63 μg/ml, respectively (P < 0.05). © 2017 Informa UK Limited, trading as Taylor & Francis Group.