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Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017 Publisher Pubmed



Yadgir S1 ; Johnson CO1, 2, 3 ; Aboyans V5, 6 ; Adebayo OM7, 12 ; Adedoyin RA8 ; Afarideh M9 ; Alahdab F14 ; Alashi A15 ; Alipour V16, 17 ; Arabloo J16 ; Azari S16 ; Barthelemy CM1, 4 ; Benziger CP19 ; Berman AE20 Show All Authors
Authors
  1. Yadgir S1
  2. Johnson CO1, 2, 3
  3. Aboyans V5, 6
  4. Adebayo OM7, 12
  5. Adedoyin RA8
  6. Afarideh M9
  7. Alahdab F14
  8. Alashi A15
  9. Alipour V16, 17
  10. Arabloo J16
  11. Azari S16
  12. Barthelemy CM1, 4
  13. Benziger CP19
  14. Berman AE20
  15. Bijani A21
  16. Carrero JJ22
  17. Carvalho F23, 24
  18. Daryani A28
  19. Duraes AR26, 27
  20. Esteghamati A9
  21. Farid TA29
  22. Farzadfar F10
  23. Fernandes E25
  24. Filip I30, 31, 32
  25. Gad MM15
  26. Hamidi S33
  27. Hay SI1
  28. Ilesanmi OS34
  29. Naghibi Irvani SS35
  30. Jurisson M36
  31. Kasaeian A11
  32. Kengne AP37
  33. Khan AR29
  34. Kisa A39, 40
  35. Kisa S41
  36. Kolte D42, 43
  37. Manafi N18
  38. Manafi A44, 45
  39. Mensah GA38
  40. Mirrakhimov EM46, 47
  41. Mohammad Y48, 50
  42. Mokdad AH1
  43. Negoi RI49, 50
  44. Thi Nguyen HL51
  45. Nguyen TH52
  46. Nixon MR1
  47. Otto CM4
  48. Patel S53
  49. Pilgrim T54
  50. Radfar A55, 56
  51. Rawaf DL57
  52. Rawaf S58, 59, 60
  53. Rawasia WF61, 68
  54. Rezapour A16
  55. Roever L62
  56. Saad AM63
  57. Saadatagah S13
  58. Senthilkumaran S64
  59. Sliwa K38
  60. Tesfay BE65
  61. Tran BX66
  62. Ullah I67, 68
  63. Vaduganathan M69, 70
  64. Vasankari TJ70
  65. Wolfe CDA71, 72
  66. Yonemoto N73
  67. Roth GA1
Show Affiliations
Authors Affiliations
  1. 1. Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States
  2. 2. Department of Health Metrics Sciences, University of Washington, Seattle, United States
  3. 3. School of Medicine, University of Washington, Seattle, United States
  4. 4. Division of Cardiology, University of Washington, Seattle, United States
  5. 5. Department of Cardiology, Dupuytren University Hospital, Limoges, France
  6. 6. Institute of Epidemiology, University of Limoges, France
  7. 7. College of Medicine, University College Hospital, College of Medicine, University College Hospital, Ibadan, Oyo, Nigeria
  8. 8. Department of Medical Rehabilitation, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria
  9. 9. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Iran
  10. 10. Non-communicable Diseases Research Center, Tehran University of Medical Sciences, Iran
  11. 11. Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Iran
  12. 12. Hematologic Malignancies Research Center, Tehran University of Medical Sciences, Iran
  13. 13. Department of Cardiology, Tehran University of Medical Sciences, Iran
  14. 14. Evidence Based Practice Center, Mayo Clinic Foundation for Medical Education and Research, Rochester, MN, United States
  15. 15. Department of Cardiovascular Medicine, Cleveland Clinic, OH, United States
  16. 16. Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran
  17. 17. Health Economics Department, Iran University of Medical Sciences, Tehran, Iran
  18. 18. Ophthalmology Department, Iran University of Medical Sciences, Tehran, Iran
  19. 19. Heart and Vascular Center, Essentia Health, Duluth, MN, United States
  20. 20. Department of Medicine, Medical College of Georgia at Augusta University, United States
  21. 21. Social Determinants of Health Research Center, Babol University of Medical Sciences, Mazandaran, Iran
  22. 22. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  23. 23. Applied Molecular Biosciences Unit, University of Porto, Portugal
  24. 24. Institute of Public Health, University of Porto, Portugal
  25. 25. REQUIMTE/LAQV, University of Porto, Portugal
  26. 26. Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  27. 27. School of Medicine, Federal University of Bahia, Salvador, Brazil
  28. 28. Medical Board, Roberto Santos General Hospital, Salvador, Bahia, Brazil
  29. 29. Division of Cardiovascular Medicine, University of Louisville, KY, United States
  30. 30. Psychiatry Department, Kaiser Permanente, Fontana, CA, United States
  31. 31. Department of Health Sciences, A.T. Still University, Mesa, AZ, United States
  32. 32. Gillings School of Global Public Health, University of North Carolina, Chapel Hill, United States
  33. 33. School of Health and Environmental Studies, Hamdan Bin Mohammed Smart University, Dubai, United Arab Emirates
  34. 34. Department of Community Medicine, University of Ibadan, Nigeria
  35. 35. Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  36. 36. Institute of Family Medicine and Public Health, University of Tartu, Tartumaa, Estonia
  37. 37. Non-communicable Diseases Research Unit, Medical Research Council South Africa, Cape Town, South Africa
  38. 38. Department of Medicine, University of Cape Town, South Africa
  39. 39. Department of Health Management and Health Economics, Kristiania University College, Oslo, Norway
  40. 40. Department of Health Services Policy and Management, University of South Carolina, Columbia, United States
  41. 41. Department of Nursing and Health Promotion, Oslo Metropolitan University, Norway
  42. 42. Department of Medicine, Brown University, Providence, RI, United States
  43. 43. Ophthalmology Department, University of Manitoba, Winnipeg, Canada
  44. 44. Department of Surgery, University of Virginia, Charlottesville, United States
  45. 45. Center for Translation Research and Implementation Science, National Institutes of Health, Bethesda, MD, United States
  46. 46. Faculty of General Medicine, Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  47. 47. Department of Atherosclerosis and Coronary Heart Disease, National Center of Cardiology and Internal Disease, Bishkek, Kyrgyzstan
  48. 48. Internal Medicine Department, King Saud University, Riyadh, Saudi Arabia
  49. 49. Anatomy and Embryology Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
  50. 50. Department of Cardiology, Cardio-Aid, Bucharest, Romania
  51. 51. Institute for Global Health Innovations, Duy Tan University, Hanoi, Viet Nam
  52. 52. Center of Excellence in Behavioral Health, Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam
  53. 53. Department of Medicine, Maimonides Medical Center, Brooklyn, NY, United States
  54. 54. Department of Cardiology, University of Bern, Switzerland
  55. 55. College of Graduate Health Sciences, A.T. Still University, Mesa, AZ, United States
  56. 56. Medichem, Barcelona, Spain
  57. 57. WHO Collaborating Centre for Public Health Education and Training, Imperial College London, United Kingdom
  58. 58. Department of Primary Care and Public Health, Imperial College London, United Kingdom
  59. 59. University College London Hospitals, United Kingdom
  60. 60. Public Health England, London, United Kingdom
  61. 61. Cardiovascular Medicine, West Virginia University, Morgantown, United States
  62. 62. Department of Clinical Research, Federal University of Uberl Andia, Brazil
  63. 63. Faculty of Medicine, Ain Shams University, Cairo, Egypt
  64. 64. Emergency Department, Manian Medical Centre, ERODE, Tamil Nadu, India
  65. 65. Department of Public Health, Adigrat University, Tigray, Ethiopia
  66. 66. Department of Health Economics, Hanoi Medical University, Viet Nam
  67. 67. Gomal Center of Biochemistry and Biotechnology, Gomal University, Faisalabad, Pakistan
  68. 68. TB Culture Laboratory, Mufti Mehmood Memorial Teaching Hospital, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan
  69. 69. Heart and Vascular Center, Harvard University, Boston, MA, United States
  70. 70. UKK Institute, Tampere, Finland
  71. 71. School of Population Health & Environmental Sciences, King's College London, United Kingdom
  72. 72. Biomedical Research Council, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
  73. 73. Department of Psychopharmacology, National Center of Neurology and Psychiatry, Tokyo, Japan

Source: Circulation Published:2020


Abstract

Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700-107 900) and 35 700 (95% UI, 30 500-42 500) deaths, and 12.6 million (95% UI, 11.4 million-13.8 million) and 18.1 million (95% UI, 17.6 million-18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million-2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%-0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%-117%) and 35% (95% UI, 23%-47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases. © 2020 Lippincott Williams and Wilkins. All rights reserved.
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