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Clinical Use of Statins in Hematopoietic Stem Cell Transplantation: Old Drugs and New Horizons



Mohammadi M1 ; Vaezi M2 ; Mirrahimi B3 ; Hadjibabaie M1, 4
Authors
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Authors Affiliations
  1. 1. Clinical Pharmacy Department, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Hematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Clinical Pharmacy Department, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran

Source: International Journal of Hematology-Oncology and Stem Cell Research Published:2016

Abstract

Hydroxymethylglutaryl Co-enzyme A reductase inhibitors, also known as statins, are a class of anti- hyperlipidemic agents. These drugs have been employed vastly to reduce the morbidity and mortality of cardiovascular disorders. Soon after their introduction, benefits other than their primary actions were discovered. Along with these pleiotropic properties, a series of mainly favorable effects has been proposed in patients intended to undergo hematopoietic stem cell transplantation. These actions address some complications encountered by this special population such as graft-versus-host disease, efficacy of chemotherapy, infections, etc. This review presents the current evidence surrounding these issues. © 2016, UK Simulation Society. All rights reserved.
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