Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Saffron Supplementation Ameliorates Oxidative Damage to Sperm Dna Following a 16-Week Low-To-Intensive Cycling Training in Male Road Cyclists Publisher



Hajizadeh Maleki B1 ; Tartibian B2 ; Mooren FC1 ; Yaghoob Nezhad F3 ; Yaseri M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Sports Medicine, Justus-Liebig-University, Giessen, Germany
  2. 2. Department of Sport Injuries and Corrective Exercises, Faculty of Physical Education and Sport Sciences, Allameh Tabataba'i University, Tehran, Iran
  3. 3. Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Urmia University, Urmia, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Functional Foods Published:2016


Abstract

The effects of the natural food saffron (90 mg/d) on exercise induced sperm DNA damage, antioxidative and peroxidative biomarkers and seminological profile in male road cyclists were evaluated. Twenty-four healthy nonprofessional cyclists (aged 17-26 years. ) were randomly assigned to exercise + Saffron (EX + SAF, n = 12) and exercise (EX, n = 12) groups for an experimental period of 16 weeks. After the intervention, the number of terminal deoxynucleotidyl transferase-mediated fluorescein-dUTP nick end labeling (TUNEL)-positive sperm cells and peroxidative biomarkers increased, while antioxidative biomarkers and seminological profile decreased in the EX group. These changes were significantly attenuated in the EX + SAF group. Moreover, for both groups the observed changes in peroxidative and antioxidative biomarkers could be correlated positively and negatively, respectively, with sperm DNA fragmentation. Saffron, rich in carotenoids, flavonoids and vitamins, is therefore a potentially potent functional food for preventing exercise-induced sperm DNA damage, at least in part, through optimizing oxidant/antioxidant equilibrium and attenuation of oxidative stress. © 2015 Elsevier Ltd.
Related Docs
View other Related Docs
1. Evaluation of Ros-Tac Score and Dna Damage in Fertile Normozoospermic and Infertile Asthenozoospermic Males, Urology Journal (2017)
2. Correlation Between Sperm Dna Fragmentation Index and Cma3 Positive Spermatozoa in Globozoospermic Patients, Andrology (2015)
3. Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review, Neurochemical Research (2020)
4. Supplementation of Sperm Freezing Medium With Myoinositol Improve Human Sperm Parameters and Protects It Against Dna Fragmentation and Apoptosis, Cell and Tissue Banking (2019)
5. Effect of Sulforaphane on Apoptosis, Reactive Oxygen Species and Lipids Peroxidation of Human Sperm During Cryopreservation, Cryobiology (2021)
6. Effect of Alpinia Officinarum Hance Rhizome Extract on Spermatogram Factors in Men With Idiopathic Infertility: A Prospective Double-Blinded Randomised Clinical Trial, Andrologia (2019)
7. Effect of Trolox on Sperm Quality in Normozospermia and Oligozospermia During Cryopreservation, Cryobiology (2016)
8. Assessment of the Impact Induced by Different Incubation Time, Storage Time, Storage Medium and Thawing Methods on Sperm Dna Fragmentation Assay: A Before–After Study, Journal of Human Reproductive Sciences (2022)
Experts (# of related papers)
View all Related Experts
Fardin Amidi (11)
Mohammad Ali Sadighi Gilani (7)
Other Related Docs
9. The Toxicity of Saffron (Crocus Sativus L.) and Its Constituents Against Normal and Cancer Cells, Journal of Nutrition and Intermediary Metabolism (2016)
10. Does Myoinositol Supplement Improve Sperm Parameters and Dna Integrity in Patients With Oligoasthenoteratozoospermia After the Freezing–Thawing Process?, Cell and Tissue Banking (2020)
11. Efficacy of Crocus Sativus L. on Reduction of Cadmium-Induced Toxicity on Spermatogenesis in Adult Rats, Andrologia (2016)
12. Prospects of Saffron and Its Derivatives in Alzheimer's Disease, Archives of Iranian Medicine (2021)
13. Therapeutic Application of Saffron for Improvement of Women’S Health: A Review of Literature, Journal of Iranian Medical Council (2021)
14. Evaluating the Potential of Three Sperm Surface Antigens As Egg-Adhesion Biomarkers for Human Sperm Selection, Journal of Reproduction and Infertility (2018)
15. Do Pilea Microphylla Improve Sperm Dna Fragmentation and Sperm Parameters in Varicocelized Rats?, Acta Medica Iranica (2015)
16. Controversy and Consensus on the Management of Elevated Sperm Dna Fragmentation in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations, World Journal of Men's Health (2023)
17. Crocus Sativus L. Versus Methylphenidate in Treatment of Children With Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind Pilot Study, Journal of Child and Adolescent Psychopharmacology (2019)
18. A Review on the Effects of Saffron Extract and Its Constituents on Factors Related to Neurologic, Cardiovascular and Gastrointestinal Diseases, Journal of Medicinal Plants (2015)
19. Cryoprotective Effect of Resveratrol on Dna Damage and Crucial Human Sperm Messenger Rnas, Possibly Through 5′ Amp-Activated Protein Kinase Activation, Cell and Tissue Banking (2018)
20. The Influence of Ginger (Zingiber Officinale) on Human Sperm Quality and Dna Fragmentation: A Double-Blind Randomized Clinical Trial, International Journal of Reproductive BioMedicine (2016)
21. The Effect of Saffron on Weight and Lipid Profile: A Systematic Review, Meta-Analysis, and Dose–Response of Randomized Clinical Trials, Phytotherapy Research (2019)
22. The Effect of Astaxanthin After Varicocele Surgery on Antioxidant Status and Semen Quality in Infertile Men: A Triple-Blind Randomized Clinical Trial, Food Science and Nutrition (2024)
23. Crocus Sativus L Versus Citalopram in the Treatment of Major Depressive Disorder With Anxious Distress: A Double-Blind, Controlled Clinical Trial, Pharmacopsychiatry (2017)
24. Evaluation of the Nox5 Protein Expression and Oxidative Stress in Sperm From Asthenozoospermic Men Compared to Normozoospermic Men, Journal of Endocrinological Investigation (2019)
25. Evaluation of the P53 and Thioredoxin Reductase in Sperm From Asthenozoospermic Males in Comparison to Normozoospermic Males, Free Radical Biology and Medicine (2018)
26. Effect of Brain-Derived Neurotrophic Factor on Sperm Function, Oxidative Stress and Membrane Integrity in Human, Andrologia (2017)
27. Protective Features of Resveratrol on Human Spermatozoa Cryopreservation May Be Mediated Through 5’ Amp-Activated Protein Kinase Activation, Andrology (2017)
28. Evaluation of Modulatory Effects of Saffron (Crocus Sativus L.) Aqueous Extract on Oxidative Stress in Ischemic Stroke Patients: A Randomized Clinical Trial, Nutritional Neuroscience (2022)
29. Comparison of Saffron Versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial, Pharmacopsychiatry (2017)
30. Efficacy and Safety of Saffron As Adjunctive Therapy in Adults With Attention-Deficit/Hyperactivity Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Advances in Integrative Medicine (2022)
31. Pentoxifylline Promotes Spermatogenesis Via Upregulation of the Nrf2-Are Signalling Pathway in a Mouse Model of Germ-Cell Apoptosis Induced by Testicular Torsion-Detorsion, Reproduction# Fertility and Development (2023)
32. Evaluation of Sperm Dna Fragmentation and Chromatin Structure in Infertile Men With Immotile Short-Tail Sperm Defect, Andrologia (2020)
33. The Effect of Crocus Sativus (Saffron) on the Severity of Premenstrual Syndrome, European Journal of Integrative Medicine (2016)
34. Assessing the Potential of Hspa2 and Adam2 As Two Biomarkers for Human Sperm Selection, Human Fertility (2020)
35. Controversy and Consensus on Indications for Sperm Dna Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations, World Journal of Men's Health (2023)
36. Effect of Brain-Derived Neurotrophic Factor (Bdnf) on Sperm Quality of Normozoospermic Men, Human Fertility (2018)
37. Review of Local Herbal Compounds Found in the Iranian Traditional Medicine Known to Optimise Male Fertility, Andrologia (2016)
38. Saffron As a Promising Therapy for Diabetes and Alzheimer's Disease: Mechanistic Insights, Metabolic Brain Disease (2023)
39. Supplementation of Freezing and Thawing Media With Brain-Derived Neurotrophic Factor Protects Human Sperm From Freeze-Thaw-Induced Damage, Fertility and Sterility (2016)
40. The Role of Antioxidants in Sperm Freezing: A Review, Cell and Tissue Banking (2016)
41. Curcumin Nanomicelle Improves Semen Parameters, Oxidative Stress, Inflammatory Biomarkers, and Reproductive Hormones in Infertile Men: A Randomized Clinical Trial, Phytotherapy Research (2018)
42. The Knowledge Domain and Emerging Trends in the Infertility Field: A 67-Year Retrospective Study, Health Care for Women International (2024)
43. Male Factors: The Role of Sperm in Preimplantation Embryo Quality, Reproductive Sciences (2021)
44. Phoenix Dactylifera L. Pollen Versus Pentoxifylline on Improvement of Sperm Parameters in Idiopathic Male Infertility: A Randomized Clinical Trial, Journal of Ethnopharmacology (2024)
45. The Effect of Crocin Supplementation on Lipid Concentrations and Fasting Blood Glucose: A Systematic Review and Meta-Analysis and Meta-Regression of Randomized Controlled Trials, Complementary Therapies in Medicine (2020)
46. Melatonin Affects Membrane Integrity, Intracellular Reactive Oxygen Species, Caspase3 Activity and Akt Phosphorylation in Frozen Thawed Human Sperm, Cell and Tissue Research (2018)
47. An Evidence-Based Approach to Medicinal Plants for the Treatment of Sperm Abnormalities in Traditional Persian Medicine, Andrologia (2016)
48. Saffron: The Golden Spice With Therapeutic Properties on Digestive Diseases, Nutrients (2019)