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Manganese Intake and Risk of Esophageal Cancer in Golestan Cohort Study



Hashemian M1, 2 ; Poustchi H3 ; Nasrabadi FM4 ; Sharafkhah M2 ; Malekshah AF2 ; Hekmatdoost A5 ; Malekzadeh R6
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Authors Affiliations
  1. 1. Department of Nutrition and Biochemistry, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
  2. 2. Researcher, Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, TehranUniversity of Medical Sciences, Tehran, Iran
  4. 4. Food and Nutrition Policy and Planning Research Department, National Nutrition and Food Technology Research Institute, ShahidBeheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, ShahidBeheshti University of Medical Sciences, Tehran, Iran
  6. 6. Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, N.Kargar St., Tehran, 14117, Iran

Source: Govaresh Published:2016

Abstract

Background: Dietary factors such as intake of minerals may play a role in the etiology of esophageal cancer. Although it has been hypothesized that manganese can affect the risk of some types ofcancer, its role in esophageal cancer is unknown. The objective of this study was to investigate the association between intakes of manganese with esophageal cancer in Golestan Cohort Study. Materials and Methods: Golestan Cohort Study was launched in Golestan province, northeast Iran, and 50000 participants were enrolled from January 2004 to June 2008. Intake of manganese was assessed with a validated food frequency questionnaire. A Cox proportional hazard model was used to estimate hazard risks and 95% confidence intervals. Results: During the follow-up period, we identified 201cases of esophageal cancer according to the reports of pathological evaluations. Manganese intake was not significantly associated with the risk of esophageal cancer (Hazard Ratio (HR) for the top versus bottom quartile = 1.49, 95% CI: 0.91-2.45, p for trend =0.09). HR for 1 mg increase in manganese intake was1.05, (95% CI: 0.98-1.11, p=0.15). Although the graphical Restricted cubic spline (RCS) plots showed that the associations between manganeseand risk of ESCC washyperbolic-shaped, P for non-linear association was not significant (p =0.08).Conclusion: Manganese intake is not associated with the risk of esophageal cancer in linear pattern.
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