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A Review on the Role of Mirna-324 in Various Diseases Publisher



Kadkhoda S1 ; Hussen BM2, 3 ; Eslami S4, 5 ; Ghafourifard S6
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq
  3. 3. Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq
  4. 4. Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Genetics Published:2022


Abstract

Recent studies have revealed important functions of several microRNAs (miRNAs) in the pathogenesis of human diseases. miR-324 is an example of miRNAs with crucial impacts on the pathogenesis of a wide range of disorders. Gene ontology studies have indicated possible role of miR-324 in responses of cells to the leukemia inhibitory factor, long-term synaptic potentiation, positive regulation of cytokines production and sensory perception of sound. In human, miR-324 is encoded by MIR324 gene which resides on chromosome 17p13.1. In the current manuscript, we provide a concise review of the role of miR-324 in the pathogenesis of cancers as well as non-cancerous conditions such as aneurysmal subarachnoid hemorrhage, diabetic nephropathy, epilepsy, pulmonary/renal fibrosis, ischemic stroke and ischemia reperfusion injuries. Moreover, we summarize the role of this miRNA as a prognostic marker for malignant disorders. Copyright © 2022 Kadkhoda, Hussen, Eslami and Ghafouri-Fard.
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