The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion

The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion Publisher Pubmed

Zandi M¹ ; Shafaati M^{2, 3} ; Kalantarneyestanaki D^{4, 5} ; Pourghadamyari H^{6, 7} ; Fani M⁸ ; Soltani S¹ ; Kaleji H¹ ; Abbasi S⁹

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1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Microbiology, Faculty Science, Jahrom Branch, Islamic Azad University, Jahrom, Iran
3. Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, Kerman, Iran
5. Department of Medical Microbiology (Bacteriology & Virology), Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
6. Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
7. Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
8. Department of Pathobiology & Laboratory Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
9. Department of Microbiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran

Source: Biomedicine and Pharmacotherapy Published:2022

Abstract

Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2 genome encodes some accessory proteins that are essential for infection. Notably, accessory proteins of SARS-CoV-2 play significant roles in affecting immune escape and viral pathogenesis. Therefore SARS-CoV-2 accessory proteins could be considered putative drug targets. IFN-I and IFN-III responses are the primary mechanisms of innate antiviral immunity in infection clearance. Previous research has shown that SARS-CoV-2 suppresses IFN-β by infecting host cells via ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, and ORF9b. Furthermore, ORF3a, ORF7a, and ORF7b have a role in blocking IFNα signaling, and ORF8 represses IFNβ signaling. The ORF3a, ORF7a, and ORF7b disrupt the STAT1/2 phosphorylation. ORF3a, ORF6, ORF7a, and ORF7b could prevent the ISRE promoter activity. The main SARS-CoV-2 accessory proteins involved in immune evasion are discussed here for comprehensive learning on viral entry, replication, and transmission in vaccines and antiviral development. © 2022

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Style	Citing Format
MLA	Zandi M, et al.. "The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion." Biomedicine and Pharmacotherapy, vol. 156, no. , 2022, pp. -.
APA	Zandi M, Shafaati M, Kalantarneyestanaki D, Pourghadamyari H, Fani M, Soltani S, Kaleji H, Abbasi S (2022). The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion. Biomedicine and Pharmacotherapy, 156(), -.
Chicago	Zandi M, Shafaati M, Kalantarneyestanaki D, Pourghadamyari H, Fani M, Soltani S, Kaleji H, Abbasi S. "The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion." Biomedicine and Pharmacotherapy 156, no. (2022): -.
Harvard	Zandi M et al. (2022) 'The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion', Biomedicine and Pharmacotherapy, 156(), pp. -.
Vancouver	Zandi M, Shafaati M, Kalantarneyestanaki D, Pourghadamyari H, Fani M, Soltani S, et al.. The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion. Biomedicine and Pharmacotherapy. 2022;156():-.
BibTex	@article{ author = {Zandi M and Shafaati M and Kalantarneyestanaki D and Pourghadamyari H and Fani M and Soltani S and Kaleji H and Abbasi S}, title = {The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion}, journal = {Biomedicine and Pharmacotherapy}, volume = {156}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Zandi M AU - Shafaati M AU - Kalantarneyestanaki D AU - Pourghadamyari H AU - Fani M AU - Soltani S AU - Kaleji H AU - Abbasi S TI - The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion JO - Biomedicine and Pharmacotherapy VL - 156 IS - SP - EP - PY - 2022 ER -

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