Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion Publisher Pubmed



Zandi M1 ; Shafaati M2, 3 ; Kalantarneyestanaki D4, 5 ; Pourghadamyari H6, 7 ; Fani M8 ; Soltani S1 ; Kaleji H1 ; Abbasi S9
Authors

Source: Biomedicine and Pharmacotherapy Published:2022


Abstract

Many questions on the SARS-CoV-2 pathogenesis remain to answer. The SARS-CoV-2 genome encodes some accessory proteins that are essential for infection. Notably, accessory proteins of SARS-CoV-2 play significant roles in affecting immune escape and viral pathogenesis. Therefore SARS-CoV-2 accessory proteins could be considered putative drug targets. IFN-I and IFN-III responses are the primary mechanisms of innate antiviral immunity in infection clearance. Previous research has shown that SARS-CoV-2 suppresses IFN-β by infecting host cells via ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, and ORF9b. Furthermore, ORF3a, ORF7a, and ORF7b have a role in blocking IFNα signaling, and ORF8 represses IFNβ signaling. The ORF3a, ORF7a, and ORF7b disrupt the STAT1/2 phosphorylation. ORF3a, ORF6, ORF7a, and ORF7b could prevent the ISRE promoter activity. The main SARS-CoV-2 accessory proteins involved in immune evasion are discussed here for comprehensive learning on viral entry, replication, and transmission in vaccines and antiviral development. © 2022
Experts (# of related papers)
Other Related Docs
5. A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein, Computers in Biology and Medicine (2021)
6. The Role of Type I Interferon in the Treatment of Covid-19, Journal of Medical Virology (2022)
16. Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2, International Journal of Biological Macromolecules (2021)
18. An Overview on the Seven Pathogenic Human Coronaviruses, Reviews in Medical Virology (2022)