Stem Cells and Natural Agents in the Management of Neurodegenerative Diseases: A New Approach Publisher Pubmed



Brockmueller A¹ ; Mahmoudi N² ; Movaeni AK² ; Mueller AL¹ ; Kajbafzadeh AM² ; Shakibaei M¹ ; Zolbin MM² Show Affiliations
Source: Neurochemical Research Published:2023

Abstract

Neurodegenerative diseases refer to a group of neurological disorders as a consequence of various destructive illnesses, that predominantly impact neurons in the central nervous system, resulting in impairments in certain brain functions. Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis, and other neurodegenerative disorders represent a major risk to human health. In order to optimize structural and functional recovery, reconstructive methods integrate many approaches now, to address the complex and multivariate pathophysiology of neurodegenerative disorders. Stem cells, with their unique property of regeneration, offer new possibilities in regenerative and reconstructive medicine. Concurrently, there is an important role for natural products in controlling many health sufferings and they can delay or even prevent the onset of various diseases. In addition, due to their therapeutic properties, they have been used as neuroprotective agents to treat neurodegenerative disorders. After decades of intensive research, scientists made advances in treating these disorders so far, but current therapies are still not capable of preventing the illnesses from progressing. Therefore, in this review, we focused on a new perspective combining stem cells and natural products as an innovative therapy option in the management of neurodegenerative diseases. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.