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Synergy of Titanium Dioxide Nanotubes and Polyurethane Properties for Bypass Graft Application: Excellent Flexibility and Biocompatibility Publisher



Kianpour G1 ; Bagheri R2 ; Pourjavadi A1, 3 ; Ghanbari H4
Authors
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Authors Affiliations
  1. 1. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, P.O. Box: 14588 89694, Tehran, Iran
  2. 2. Polymeric Materials Research Group (PMRG), Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box: 11155-9466, Tehran, Iran
  3. 3. Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, P.O. Box: 11365-9516, Tehran, Iran
  4. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, P.O. Box: 1417755469, Tehran, Iran

Source: Materials and Design Published:2022


Abstract

A flexible, porous and biocompatible titanium dioxide nanotubes (TNT) - polyurethane (PU) film has been produced as a new scaffold for artificial vascular grafts. Synergistic improvements in the properties of vertical TNT and PU was reached, including enhancements in their biocompatibility, mechanical strength, flexibility and porosity. Open-ended (OE) TNT-PU and close-ended (CE) TNT-PU films were synthesized and their mechanical and biological properties were compared with their pure PU counterparts. TNT were attached to PU with a new strategy. The resulting flexible structure was hydrophilic and super hydrophilic in OE-TNT-PU and CE-TNT-PU scaffolds, respectively. The gas leakage during the attachment of polymers and nanotubes led to an interconnected porous structure of the polymer. The results revealed that the rate of endothelialization of the OE-TNT-PU scaffold vs pure PU scaffolds was 2 times greater after 5 days of in vitro cell culture. In addition, the number of platelets and their agglomeration on the newly designed scaffolds were much lower than those of PU scaffolds. In OE-TNT-PU film, the elongation at break was 881% and the ultimate tensile strength was more than 3 times greater compared to PU. The Young modulus of these scaffolds was greater than150 MPa. © 2022 The Authors
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Hossein Ghanbari (1)