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Higher Covid-19 Pneumonia Risk Associated With Anti-Ifn-Α Than With Anti-Ifn-Ω Auto-Abs in Children Publisher Pubmed



Bastard P1, 2, 3, 4, 99 ; Gervais A1, 2 ; Taniguchi M5 ; Saare L6 ; Sarekannu K7 ; Voyer TL1, 2 ; Philippot Q1, 2 ; Rosain J1, 2 ; Bizien L1, 2 ; Asano T5 ; Garciaprat M8 ; Parramartinez A8 ; Migaud M1, 2 ; Tsumura M5 Show All Authors
Authors
  1. Bastard P1, 2, 3, 4, 99
  2. Gervais A1, 2
  3. Taniguchi M5
  4. Saare L6
  5. Sarekannu K7
  6. Voyer TL1, 2
  7. Philippot Q1, 2
  8. Rosain J1, 2
  9. Bizien L1, 2
  10. Asano T5
  11. Garciaprat M8
  12. Parramartinez A8
  13. Migaud M1, 2
  14. Tsumura M5
  15. Conti F9, 10
  16. Belot A11, 12, 14, 109
  17. Riviere JG8
  18. Morio T15, 172
  19. Tanaka J16
  20. Javouhey E17
  21. Haerynck F18, 145
  22. Duvlis S19, 20
  23. Ozcelik T21, 181
  24. Keles S22
  25. Tandjaouilambiotte Y23, 24, 25
  26. Escoda S26
  27. Husain M26
  28. Panhammarstrom Q27, 149
  29. Hammarstrom L27, 149
  30. Ahlijah G1
  31. Haidar AA1
  32. Soudee C1
  33. Arseguel V1
  34. Abolhassani H27, 28
  35. Sahanic S29
  36. Tancevski I29, 211
  37. Nukui Y30
  38. Hayakawa S5
  39. Chrousos GP31
  40. Michos A31, 32
  41. Tatsi EB31, 32
  42. Filippatos F31, 32
  43. Rodriguezpalmero A33, 34, 35
  44. Troya J36
  45. Tipu I37
  46. Meyts I38, 39, 166, 167, 168
  47. Roussel L40, 41
  48. Ostrowski SR42
  49. Schidlowski L43
  50. Prando C43
  51. Condinoneto A44, 123
  52. Cheikh N45
  53. Bousfiha AA46, 114
  54. Bakkouri JE47
  55. Peterson P7
  56. Pujol A48, 188, 189, 190
  57. Levy R1, 2, 4
  58. Quartier P2, 4
  59. Vinh DC40, 41, 223, 224
  60. Boisson B1, 2, 3
  61. Beziat V1, 2, 3
  62. Zhang SY1, 2, 3, 99
  63. Borghesi A49
  64. Pession A9
  65. Andreakos E50
  66. Marr N51
  67. Mentis AFA31
  68. Hmogensen T52, 53
  69. Rodriguezgallego C54, 55, 56, 195, 196
  70. Solerpalacin P8, 207
  71. Colobran R57, 122
  72. Tillmann V6
  73. Neven B2, 4
  74. Trouilletassant S13, 14, 58
  75. Brodin P60, 61, 115
  76. Abel L1, 2, 3, 99
  77. Jouanguy E1, 2, 3, 99
  78. Zhang Q1, 2, 3, 99
  79. Martinontorres F62, 63, 64, 87
  80. Salas A64, 65, 88
  81. Gomezcarballa A63, 64, 65
  82. Gonzalezgranado LI66
  83. Kisand K7, 159
  84. Okada S5, 179
  85. Puel A1, 2, 3, 99
  86. Cobat A1, 2, 3, 99
  87. Casanova JL1, 2, 3, 68, 118, 119
  88. Aguileraalbesa S69
  89. Alkhater SA70, 71
  90. Alkan G72
  91. Castagnoli R73, 86
  92. Cyrus C74
  93. Bozdemir SE75
  94. Emiroglu M72
  95. Gulhan B76
  96. Erdeniz EH77
  97. Hatipoglu N78
  98. Bayhan GI79
  99. Jabandziev P80
  100. Yuksek SK81
  101. Karbuz A82
  102. Oz SKT72
  103. Marseglia GL73, 86
  104. Akcan OM83
  105. Kilic AO83
  106. Parlakay AO76
  107. Papadaki M50
  108. Slaba K80
  109. Sevketoglu E85
  110. Valenciaramos J84
  111. Yahsi A76
  112. Tuala C87
  113. Urbieta AID87
  114. Esteban BD87
  115. Santalla MJD91
  116. Perez CF95
  117. Villaverde JF92
  118. Rodriguez CG92
  119. Allut JLG92
  120. Vicente LG87
  121. Vazquez EG92
  122. Carballa AG87
  123. Rial JG87
  124. Barcala FJG90
  125. Linares BG95
  126. Iglesias PL87
  127. Massa BL92
  128. Fuentes ML87
  129. Franco ML87
  130. Lago AL92
  131. Cruz DNDL89
  132. Masid EN96
  133. Devesa JBO94
  134. Seco JP87
  135. Nunez MP91
  136. Bernal MPM89
  137. Freixo HP95
  138. Rodriguez LP87
  139. Pischedda S87
  140. Romero MP97
  141. Reino AP91
  142. Hervella GMP93
  143. Verdes TQ95
  144. Collazo LR87
  145. Casuso PR87
  146. Garcia SR87
  147. Vazquez SR87
  148. Blanco VR90
  149. Calle IR87
  150. Velasco CR92
  151. Nunez NR90
  152. Sanchez CRT87
  153. Paz ES92
  154. Orayyou JMS87
  155. Villanueva CS92
  156. Fernandez SS87
  157. Sanmartin PS95
  158. Muniz MT93
  159. Pena RT89
  160. Castellano MT89
  161. Cuadrado LV90
  162. Garcia PV91
  163. Iglesias MSV87
  164. Lasheras SV87
  165. Ferreiroiglesias R98
  166. Bastonrey I98
  167. Calvinosuarez C98
  168. Aiuti A100
  169. Almuhsen S101
  170. Almulla F102
  171. Amara A103
  172. Anderson MS104
  173. Arias AA3, 105, 106
  174. Arkin LM107
  175. Feldman HB108
  176. Biggs CM110
  177. Bogunovic D111
  178. Bolze A112
  179. Bondarenko A113
  180. Bryceson Y116
  181. Butte MJ117
  182. Casari G120
  183. Christodoulou J121
  184. Constantinescu SN124
  185. Cooper MA125
  186. Dalgard CL126
  187. Desai M127
  188. Drolet BA128
  189. Duval X129, 130
  190. Baghdadi JE131
  191. Eloy P132
  192. Espinosapadilla S133
  193. Fellay J134
  194. Flores C135
  195. Franco JL139
  196. Froidure A140, 141
  197. Gorochov G142
  198. Gregersen PK143
  199. Grimbacher B144
  200. Hagin D146
  201. Halwani R147, 148
  202. Heath JR150
  203. Hsieh EWY151
  204. Husebye E152
  205. Imai K153
  206. Itan Y154, 155
  207. Jarvis ED156
  208. Kaja E157
  209. Karamitros T158
  210. Ku CL160
  211. Lau YL161
  212. Ling Y162
  213. Lucas CL163
  214. Mansouri D164
  215. Marodi L165
  216. Mentre F132
  217. Milner JD169
  218. Mironska K170
  219. Mogensen TH171
  220. Ng LFP173, 174
  221. Notarangelo LD175
  222. Novelli A176
  223. Novelli G177
  224. Ofarrelly C178
  225. Okamoto K180
  226. Pape JW182
  227. De Diego RP183
  228. Pereztur J184
  229. Perlin DS185
  230. Pesole G186
  231. Planas AM187
  232. Quintanamurci L191, 192
  233. Ramaswamy S193
  234. Renia L173, 174
  235. Resnick I194
  236. Sanchoshimizu V197, 198
  237. Sediva A199
  238. Seppanen MRJ200, 201
  239. Shahrooei M202, 203
  240. Shcherbina A204
  241. Slaby O205
  242. Snow AL206
  243. Soumelis V208, 209
  244. Spaan AN3, 210
  245. Su HC175
  246. Tangye SG212, 213
  247. Tayoun AA193
  248. Temel SG214, 215
  249. Thorball C216
  250. Tiberghien P217
  251. Turvey SE218
  252. Uddin KMF219
  253. Uddin MJ220, 221
  254. Beek D222
  255. Bernuth HV225, 226, 227
  256. Wauters J228
  257. Zatz M229
  258. Zawadzki P230

Source: Journal of Experimental Medicine Published:2024


Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2. © 2024, Rockefeller University Press. All rights reserved.
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