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Higher Covid-19 Pneumonia Risk Associated With Anti-Ifn-Α Than With Anti-Ifn-Ω Auto-Abs in Children Publisher Pubmed



Bastard P1, 2, 3, 4, 99 ; Gervais A1, 2 ; Taniguchi M5 ; Saare L6 ; Sarekannu K7 ; Voyer TL1, 2 ; Philippot Q1, 2 ; Rosain J1, 2 ; Bizien L1, 2 ; Asano T5 ; Garciaprat M8 ; Parramartinez A8 ; Migaud M1, 2 ; Tsumura M5 Show All Authors
Authors
  1. Bastard P1, 2, 3, 4, 99
  2. Gervais A1, 2
  3. Taniguchi M5
  4. Saare L6
  5. Sarekannu K7
  6. Voyer TL1, 2
  7. Philippot Q1, 2
  8. Rosain J1, 2
  9. Bizien L1, 2
  10. Asano T5
  11. Garciaprat M8
  12. Parramartinez A8
  13. Migaud M1, 2
  14. Tsumura M5
  15. Conti F9, 10
  16. Belot A11, 12, 14, 109
  17. Riviere JG8
  18. Morio T15, 172
  19. Tanaka J16
  20. Javouhey E17
  21. Haerynck F18, 145
  22. Duvlis S19, 20
  23. Ozcelik T21, 181
  24. Keles S22
  25. Tandjaouilambiotte Y23, 24, 25
  26. Escoda S26
  27. Husain M26
  28. Panhammarstrom Q27, 149
  29. Hammarstrom L27, 149
  30. Ahlijah G1
  31. Haidar AA1
  32. Soudee C1
  33. Arseguel V1
  34. Abolhassani H27, 28
  35. Sahanic S29
  36. Tancevski I29, 211
  37. Nukui Y30
  38. Hayakawa S5
  39. Chrousos GP31
  40. Michos A31, 32
  41. Tatsi EB31, 32
  42. Filippatos F31, 32
  43. Rodriguezpalmero A33, 34, 35
  44. Troya J36
  45. Tipu I37
  46. Meyts I38, 39, 166, 167, 168
  47. Roussel L40, 41
  48. Ostrowski SR42
  49. Schidlowski L43
  50. Prando C43
  51. Condinoneto A44, 123
  52. Cheikh N45
  53. Bousfiha AA46, 114
  54. Bakkouri JE47
  55. Peterson P7
  56. Pujol A48, 188, 189, 190
  57. Levy R1, 2, 4
  58. Quartier P2, 4
  59. Vinh DC40, 41, 223, 224
  60. Boisson B1, 2, 3
  61. Beziat V1, 2, 3
  62. Zhang SY1, 2, 3, 99
  63. Borghesi A49
  64. Pession A9
  65. Andreakos E50
  66. Marr N51
  67. Mentis AFA31
  68. Hmogensen T52, 53
  69. Rodriguezgallego C54, 55, 56, 195, 196
  70. Solerpalacin P8, 207
  71. Colobran R57, 122
  72. Tillmann V6
  73. Neven B2, 4
  74. Trouilletassant S13, 14, 58
  75. Brodin P60, 61, 115
  76. Abel L1, 2, 3, 99
  77. Jouanguy E1, 2, 3, 99
  78. Zhang Q1, 2, 3, 99
  79. Martinontorres F62, 63, 64, 87
  80. Salas A64, 65, 88
  81. Gomezcarballa A63, 64, 65
  82. Gonzalezgranado LI66
  83. Kisand K7, 159
  84. Okada S5, 179
  85. Puel A1, 2, 3, 99
  86. Cobat A1, 2, 3, 99
  87. Casanova JL1, 2, 3, 68, 118, 119
  88. Aguileraalbesa S69
  89. Alkhater SA70, 71
  90. Alkan G72
  91. Castagnoli R73, 86
  92. Cyrus C74
  93. Bozdemir SE75
  94. Emiroglu M72
  95. Gulhan B76
  96. Erdeniz EH77
  97. Hatipoglu N78
  98. Bayhan GI79
  99. Jabandziev P80
  100. Yuksek SK81
  101. Karbuz A82
  102. Oz SKT72
  103. Marseglia GL73, 86
  104. Akcan OM83
  105. Kilic AO83
  106. Parlakay AO76
  107. Papadaki M50
  108. Slaba K80
  109. Sevketoglu E85
  110. Valenciaramos J84
  111. Yahsi A76
  112. Tuala C87
  113. Urbieta AID87
  114. Esteban BD87
  115. Santalla MJD91
  116. Perez CF95
  117. Villaverde JF92
  118. Rodriguez CG92
  119. Allut JLG92
  120. Vicente LG87
  121. Vazquez EG92
  122. Carballa AG87
  123. Rial JG87
  124. Barcala FJG90
  125. Linares BG95
  126. Iglesias PL87
  127. Massa BL92
  128. Fuentes ML87
  129. Franco ML87
  130. Lago AL92
  131. Cruz DNDL89
  132. Masid EN96
  133. Devesa JBO94
  134. Seco JP87
  135. Nunez MP91
  136. Bernal MPM89
  137. Freixo HP95
  138. Rodriguez LP87
  139. Pischedda S87
  140. Romero MP97
  141. Reino AP91
  142. Hervella GMP93
  143. Verdes TQ95
  144. Collazo LR87
  145. Casuso PR87
  146. Garcia SR87
  147. Vazquez SR87
  148. Blanco VR90
  149. Calle IR87
  150. Velasco CR92
  151. Nunez NR90
  152. Sanchez CRT87
  153. Paz ES92
  154. Orayyou JMS87
  155. Villanueva CS92
  156. Fernandez SS87
  157. Sanmartin PS95
  158. Muniz MT93
  159. Pena RT89
  160. Castellano MT89
  161. Cuadrado LV90
  162. Garcia PV91
  163. Iglesias MSV87
  164. Lasheras SV87
  165. Ferreiroiglesias R98
  166. Bastonrey I98
  167. Calvinosuarez C98
  168. Aiuti A100
  169. Almuhsen S101
  170. Almulla F102
  171. Amara A103
  172. Anderson MS104
  173. Arias AA3, 105, 106
  174. Arkin LM107
  175. Feldman HB108
  176. Biggs CM110
  177. Bogunovic D111
  178. Bolze A112
  179. Bondarenko A113
  180. Bryceson Y116
  181. Butte MJ117
  182. Casari G120
  183. Christodoulou J121
  184. Constantinescu SN124
  185. Cooper MA125
  186. Dalgard CL126
  187. Desai M127
  188. Drolet BA128
  189. Duval X129, 130
  190. Baghdadi JE131
  191. Eloy P132
  192. Espinosapadilla S133
  193. Fellay J134
  194. Flores C135
  195. Franco JL139
  196. Froidure A140, 141
  197. Gorochov G142
  198. Gregersen PK143
  199. Grimbacher B144
  200. Hagin D146
  201. Halwani R147, 148
  202. Heath JR150
  203. Hsieh EWY151
  204. Husebye E152
  205. Imai K153
  206. Itan Y154, 155
  207. Jarvis ED156
  208. Kaja E157
  209. Karamitros T158
  210. Ku CL160
  211. Lau YL161
  212. Ling Y162
  213. Lucas CL163
  214. Mansouri D164
  215. Marodi L165
  216. Mentre F132
  217. Milner JD169
  218. Mironska K170
  219. Mogensen TH171
  220. Ng LFP173, 174
  221. Notarangelo LD175
  222. Novelli A176
  223. Novelli G177
  224. Ofarrelly C178
  225. Okamoto K180
  226. Pape JW182
  227. De Diego RP183
  228. Pereztur J184
  229. Perlin DS185
  230. Pesole G186
  231. Planas AM187
  232. Quintanamurci L191, 192
  233. Ramaswamy S193
  234. Renia L173, 174
  235. Resnick I194
  236. Sanchoshimizu V197, 198
  237. Sediva A199
  238. Seppanen MRJ200, 201
  239. Shahrooei M202, 203
  240. Shcherbina A204
  241. Slaby O205
  242. Snow AL206
  243. Soumelis V208, 209
  244. Spaan AN3, 210
  245. Su HC175
  246. Tangye SG212, 213
  247. Tayoun AA193
  248. Temel SG214, 215
  249. Thorball C216
  250. Tiberghien P217
  251. Turvey SE218
  252. Uddin KMF219
  253. Uddin MJ220, 221
  254. Beek D222
  255. Bernuth HV225, 226, 227
  256. Wauters J228
  257. Zatz M229
  258. Zawadzki P230
Show Affiliations
Authors Affiliations
  1. 1. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France
  2. 2. University Paris Cite, Imagine Institute, Paris, France
  3. 3. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, United States
  4. 4. Pediatric Hematology-Immunology and Rheumatology Unit, Necker Hospital for Sick Children, Assistance Publique-Hˆopitaux de Paris (AP-HP), Paris, France
  5. 5. Dept. of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  6. 6. Dept. of Pediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia
  7. 7. Molecular Pathology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  8. 8. Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain
  9. 9. Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
  10. 10. Dept. of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy
  11. 11. National Reference Center for Rheumatic, and Autoimmune and Systemic Diseases in Children, Lyon, France
  12. 12. Immunopathology Federation LIFE, Hospices Civils de Lyon, Lyon, France
  13. 13. Hospices Civils de Lyon, Lyon, France
  14. 14. International Center of Research in Infectiology, Lyon University, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France
  15. 15. Dept. of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  16. 16. Dept. of Epidemiology, Infectious Disease Control and Prevention, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  17. 17. Pediatric Intensive Care Unit, Hospices Civils de Lyon, Hopital Femme Mere Enfant, Lyon, France
  18. 18. Dept. of Paediatric Immunology and Pulmonology, Center for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
  19. 19. Faculty of Medical Sciences, University “Goce Delchev�, Stip, North Macedonia
  20. 20. Institute of Public Health of the Republic of North Macedonia, Skopje, North Macedonia
  21. 21. Dept. of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
  22. 22. Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
  23. 23. Pulmonology and Infectious Disease Department, Saint Denis Hospital, Saint Denis, France
  24. 24. INSERM UMR 1137 IAME, Paris, France
  25. 25. INSERM UMR 1272 Hypoxia and Lung, Bobigny, France
  26. 26. Pediatric Dept., Saint-Denis Hospital, Saint-Denis, France
  27. 27. Division of Immunology, Dept. of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
  28. 28. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  29. 29. Dept. of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
  30. 30. Dept. of Infection Control and Prevention, Medical Hospital, TMDU, Tokyo, Japan
  31. 31. University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, Athens, Greece
  32. 32. First Dept. of Pediatics, National and Kapodistrian University of Athens, Athens, Greece
  33. 33. Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
  34. 34. Dept. of Pediatrics, Germans Trias i Pujol University Hospital, UAB, Barcelona, Spain
  35. 35. Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER), Madrid, Spain
  36. 36. Dept. of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain
  37. 37. University of Management and Technology, Lahore, Pakistan
  38. 38. Dept. of Immunology, Laboratory of Inborn Errors of Immunity, Microbiology and Transplantation, KU Leuven, Leuven, Belgium
  39. 39. Dept. of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center, University Hospitals Leuven, Leuven, Belgium
  40. 40. Dept. of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montreal, Canada
  41. 41. Infectious Disease Susceptibility Program, Research Institute–McGill University Health Centre, Montreal, Canada
  42. 42. Dept. of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  43. 43. Faculdades Pequeno Principe, Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil
  44. 44. Dept. of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  45. 45. Pediatric Hematology Unit, University Hospital of Besancon, Besancon, France
  46. 46. Dept. of Pediatric Infectious Disease and Clinical Immunology, CHU Ibn Rushd and LICIA, Laboratoire d’Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
  47. 47. Laboratory of Immunology, CHU Ibn Rushd and LICIA, Laboratoire d’Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
  48. 48. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, CIBERER U759, Catalan Institution of Research and Advanced Studies, Barcelona, Spain
  49. 49. Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  50. 50. Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
  51. 51. Research Branch, Sidra Medicine, Doha, Qatar
  52. 52. Dept. of Infectious Diseases, Aarhus University Hospital, Skejby, Denmark
  53. 53. Dept. of Biomedicine, Aarhus University, Aarhus, Denmark
  54. 54. Hospital Universitario de Gran Canaria Dr Negrin, Canarian Health System, Las Palmas, Spain
  55. 55. Dept. of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  56. 56. Dept. of Medical and Surgical Sciences, School of Medicine, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain
  57. 57. Immunology Division, Genetics Dept., Hospital Universitari Vall d’Hebron, Vall d’Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus, UAB, Barcelona, Spain
  58. 58. Joint Research Unit, Hospices Civils de Lyon-bio Merieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre- Benite, France
  59. 59. International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France
  60. 60. Unit for Clinical Pediatrics, Dept. of Women’s and Children’s Health, Karolinska Institutet, Solna, Sweden
  61. 61. Department of Immunology and Inflammation, Imperial College London, London, United Kingdom
  62. 62. Translational Pediatrics and Infectious Diseases, Pediatrics Dept., Hospital Clinico Universitario de Santiago, Servizo Galego de Saude (SERGAS), Santiago de Compostela, Spain
  63. 63. GENVIP Research Group, Instituto de Investigacion Sanitaria de Santiago (IDIS), Universidad de Santiago de Compostela, Galicia, Spain
  64. 64. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
  65. 65. Facultade de Medicina, Unidade de Xenetica, Instituto de Ciencias Forenses, Universidade de Santiago de Compostela, and GenPoB Research Group, IDIS, SERGAS, Galicia, Spain
  66. 66. Immunodeficiencies Unit, Hospital 12 de octubre, Research Institute Hospital 12 octubre, Madrid, Spain
  67. 67. Howard Hughes Medical Institute, New York, NY, United States
  68. 68. Dept. of Pediatrics, Necker Hospital for Sick Children, AP-HP, Paris, France
  69. 69. Navarra Health Service Hospital, Pamplona, Spain
  70. 70. Department of Pediatrics, King Fahad Hospital of the University, Al Khobar, Saudi Arabia
  71. 71. College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  72. 72. Selcuk University, Faculty of Medicine, Konya, Turkey
  73. 73. Pediatric Unit, Department of Clinical, Surgical, Diagnostic, and Pediatric Sciences, University of Pavia, Pavia, Italy
  74. 74. Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  75. 75. Bursa City Hospital, Bursa, Turkey
  76. 76. Ankara City Hospital, Children’s Hospital, Ankara, Turkey
  77. 77. Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey
  78. 78. Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  79. 79. Yildirim Beyazit University, Faculty of Medicine, Ankara City Hospital, Children’s Hospital, Ankara, Turkey
  80. 80. Department of Pediatrics, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  81. 81. Health Science University Ankara City Hospital, Ankara, Turkey
  82. 82. Cemil Tascioglu City Hospital, Istanbul, Turkey
  83. 83. Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
  84. 84. University Hospital of Burgos, Burgos, Spain
  85. 85. Pediatric Intensive Care Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  86. 86. Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  87. 87. Translational Pediatrics and Infectious Diseases, Pediatrics Department, Hospital Clinico Universitario de Santiago, GENVIP Research Group, Instituto de Investigacion Sanitaria de Santiago, Universidad de Santiago de Compostela, Galicia, Santiago de Compostela, Spain
  88. 88. Unidade de Xenetica, Departamento de Anatomia Patoloxica e Ciencias Forenses, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPop Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clinico Universitario de Santiago, Galicia, Spain
  89. 89. Microbiology Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  90. 90. Pneumology Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  91. 91. Internal Medicine Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  92. 92. Intensive Care Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  93. 93. Anesthesiology and Resuscitation Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  94. 94. Clinical Chemistry Laboratory, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  95. 95. Preventive Medicine Unit, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  96. 96. Manager of the Health Care Area of Santiago de Compostela and Barbanza, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  97. 97. Pharmaceutical Delivery, Training, Teaching, Research and Innovation, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  98. 98. Digestive Service, Hospital Clinico Universitario de Santiago, Galicia, Santiago de Compostela, Spain
  99. 99. Paris Cite University, Imagine Institute, Paris, France
  100. 100. San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Vita Salute San Raffaele University, Milan, Italy
  101. 101. Immunology Research Lab, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  102. 102. Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Dasman, Kuwait
  103. 103. Laboratory of Genomes & Cell Biology of Disease, INSERM U944, CNRS UMR 7212, Universite de Paris, Institut de Recherche Saint-Louis, Hopital Saint-Louis, Paris, France
  104. 104. Diabetes Center, University of California San Francisco, San Francisco, CA, United States
  105. 105. Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine, University of Antioquia (UdeA), Medellin, Colombia
  106. 106. School of Microbiology, University of Antioquia UdeA, Medellin, Colombia
  107. 107. Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States
  108. 108. The Genetics Institute, Tel Aviv Sourasky Medical Center and Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  109. 109. Pediatric Nephrology, Rheumatology, Dermatology, HFME, Hospices Civils de Lyon, National Referee Centre RAISE, INSERM U1111, Universite de Lyon, Lyon, France
  110. 110. Department of Pediatrics, BC Children's and St. Paul's Hospitals, University of British Columbia, Vancouver, BC, Canada
  111. 111. Icahn School of Medicine at Mount Sinai, New York, NY, United States
  112. 112. Helix, San Mateo, CA, United States
  113. 113. International European University, Kiev, Ukraine
  114. 114. Department of Pediatric Infectious Disease and Clinical Immunology, CHU Ibn Rushd and LICIA, Laboratoire d'Immunologie Clinique, Inflammation et Allergie, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
  115. 115. SciLifeLab, Department Of Women’s and Children’s Health, Karolinska Institutet, Stockholm, Sweden
  116. 116. Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden
  117. 117. Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics and the Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, United States
  118. 118. The Rockefeller University & Howard Hughes Medical Institute, New York, NY, United States
  119. 119. Necker Hospital for Sick Children & INSERM, Paris, France
  120. 120. Clinical Genomics, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy
  121. 121. Murdoch Children's Research Institute and Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia
  122. 122. Immunology Division, Genetics Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, UAB, Catalonia, Barcelona, Spain
  123. 123. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
  124. 124. de Duve Institute, UC Louvain and Ludwig Cancer Research, Brussels, Belgium
  125. 125. Washington University School of Medicine, St. Louis, MO, United States
  126. 126. Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  127. 127. Bai Jerbai Wadia Hospital for Children, Mumbai, India
  128. 128. School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States
  129. 129. Universite de Paris, IAME UMR-S 1137, INSERM, Paris, France
  130. 130. Inserm CIC 1425, Paris, France
  131. 131. Genetics Unit, Military Hospital Mohamed V, Rabat, Morocco
  132. 132. Hopital Bichat, Paris, France
  133. 133. Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico
  134. 134. School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
  135. 135. Research Unit, Hospital Universitario Nuestra Senora de Candelaria, Santa Cruz de Tenerife
  136. 136. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
  137. 137. Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), Santa Cruz de Tenerife, Spain
  138. 138. Faculty of Health Sciences, University Fernando Pessoa Canarias, Canary Islands, Las Palmas de Gran Canaria, Spain
  139. 139. Group of Primary Immunodeficiencies, University of Antioquia UDEA, Medellin, Colombia
  140. 140. Pulmonology Department, Cliniques Universitaires Saint-Luc, Belgium
  141. 141. Institut de Recherche Experimentale et Clinique (IREC), Universite Catholique de Louvain, Brussels, Belgium
  142. 142. Sorbonne Universite, Inserm, Centre d'Immunologie et des Maladies Infectieuses-Paris (CIMI PARIS), Assistance Publique-Hopitaux de Paris (AP-HP) Hopital Pitie-Salpetriere, Paris, France
  143. 143. Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, United States
  144. 144. Center for Chronic Immunodeficiency & Institute for Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
  145. 145. Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium
  146. 146. The Genetics Institute Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
  147. 147. Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, United Arab Emirates
  148. 148. Immunology Research Lab, College of Medicine, King Saud University, Riyadh, Saudi Arabia
  149. 149. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
  150. 150. Institute for Systems Biology, Seattle, WA, United States
  151. 151. Departments of Pediatrics, Immunology and Microbiology, University of Colorado, School of Medicine, Aurora, CO, United States
  152. 152. Department of Medicine, Haukeland University Hospital, Bergen, Norway
  153. 153. Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
  154. 154. Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  155. 155. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  156. 156. Laboratory of Neurogenetics of Language and Howard Hughes Medical Institute, The Rockefeller University, New York, NY, United States
  157. 157. Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland
  158. 158. Bioinformatics and Applied Genomics Unit, Hellenic Pasteur Institute, Athens, Greece
  159. 159. Molecular Pathology, Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia
  160. 160. Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan County, Taiwan
  161. 161. Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Hong Kong
  162. 162. Shanghai Public Health Clinical Center, Fudan University, Shanghai, China
  163. 163. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States
  164. 164. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, The Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti, University of Medical Sciences, Tehran, Iran
  165. 165. Primary Immunodeficiency Clinical Unit and Laboratory, Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary
  166. 166. Department of Pediatrics, University Hospitals Leuven, Belgium
  167. 167. KU Leuven, Department of Microbiology, Immunology and Transplantation, Belgium
  168. 168. Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium
  169. 169. Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, United States
  170. 170. University Clinic for Children's Diseases, Department of Pediatric Immunology, Medical Faculty, University “ St.Cyril and Methodij� Skopje, North Macedonia
  171. 171. Department of Biomedicine, Aarhus University, Aarhus, Denmark
  172. 172. Tokyo Medical & Dental University Hospital, Tokyo, Japan
  173. 173. A*STAR Infectious Disease Labs, Agency for Science, Technology and Research, Singapore
  174. 174. Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore
  175. 175. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States
  176. 176. Laboratory of Medical Genetics, IRCCS Bambino Gesu Children’s Hospital, Rome, Italy
  177. 177. Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy
  178. 178. Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
  179. 179. Department of Pediatrics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  180. 180. Tokyo Medical and Dental University, Tokyo, Japan
  181. 181. Department of Molecular Biology and Genetics, Bilkent University, Bilkent - Ankara, Turkey
  182. 182. Haitian Study Group for Kaposi's Sarcoma and Opportunistic Infections (GHESKIO), Port-au-Prince, Haiti
  183. 183. Institute of Biomedical Research of IdiPAZ, University Hospital “La Paz�, Madrid, Spain
  184. 184. Institut de Biomedicina de Valencia-CSIC, CIBERNED, ISCIII, Valencia, Spain
  185. 185. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, United States
  186. 186. Department of Biosciences, Biotechnology and Environment, University of Bari A. Moro, Bari, Italy
  187. 187. IIBB-CSIC, IDIBAPS, Barcelona, Spain
  188. 188. Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain
  189. 189. Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain
  190. 190. Center for Biomedical Research on Rare Diseases (CIBERER), ISCIII, Barcelona, Spain
  191. 191. Human Evolutionary Genetics Unit, CNRS U2000, Institut Pasteur, Paris, France
  192. 192. Human Genomics and Evolution, College de France, Paris, France
  193. 193. Al Jalila Children's Hospital, Dubai, United Arab Emirates
  194. 194. University Hospital St. Marina, Varna, Bulgaria
  195. 195. Department of Immunology, University Hospital of Gran Canaria Dr. Negrin, Canarian Health System, Las Palmas de Gran Canaria, Spain
  196. 196. Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  197. 197. Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, United Kingdom
  198. 198. Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, United Kingdom
  199. 199. Department of Immunology, Second Faculty of Medicine Charles University, V Uvalu, University Hospital in Motol, Prague, Czech Republic
  200. 200. Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  201. 201. Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  202. 202. Clinical and Diagnostic Immunology, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium
  203. 203. Dr. Shahrooei Lab, Tehran, Iran
  204. 204. Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russian Federation
  205. 205. Central European Institute of Technology & Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
  206. 206. Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
  207. 207. Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d’Hebron Barcelona Hospital Campus, Catalonia, Barcelona, Spain
  208. 208. Universite de Paris, Institut de Recherche Saint-Louis, INSERM U976, Hopital Saint- Louis, Paris, France
  209. 209. AP-HP, Hopital Saint-Louis, Laboratoire d'Immunologie, Paris, France
  210. 210. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands
  211. 211. Department of Internal Medicine II, Medical University of Innsbruck, Innsbruck, Austria
  212. 212. Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
  213. 213. St Vincent’s Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia
  214. 214. Departments of Medical Genetics & Histology and Embryology, Faculty of Medicine, Turkey
  215. 215. Department of Translational Medicine, Health Sciences Institute, Bursa Uludag University, Bursa, Turkey
  216. 216. Precision Medicine Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
  217. 217. Etablissement Francais Du Sang, La Plaine-Saint Denis, Saint-Denis, France
  218. 218. BC Children's Hospital, The University of British Columbia, Vancouver, Canada
  219. 219. Centre for Precision Therapeutics, Genetics & Genomic Medicine Centre, NeuroGen Children's Healthcare and Lecturer, Holy Family Red Crescent Medical College Dhaka, Bangladesh
  220. 220. College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  221. 221. Cellular Intelligence (Ci) Lab, GenomeArc Inc., Toronto, ON, Canada
  222. 222. Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
  223. 223. Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montreal, QC, Canada
  224. 224. Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada
  225. 225. Department of Pediatric Pneumology, Immunology and Intensive Care, Charite Universitatsmedizin, Berlin University Hospital Center, Berlin, Germany
  226. 226. Labor Berlin GmbH, Department of Immunology, Berlin, Germany
  227. 227. Berlin Institutes of Health (BIH), Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany
  228. 228. Department of General Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium
  229. 229. Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil
  230. 230. Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Poznan, Poland

Source: Journal of Experimental Medicine Published:2024


Abstract

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2. © 2024, Rockefeller University Press. All rights reserved.
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