Diminution of Sting Expression in the Blood of Patients With Severe or Critical Covid-19 Pneumonia Publisher Pubmed



Rezaei M^{1, 2, 3} ; Marjani M³ ; Mirahmadi A³ ; Bineshfar N³ ; Mohammadpour H⁴ ; Pourabdollah Toutkaboni M⁵ ; Nasr Azadani F⁶ ; Amanzade Z² ; Tabarsi P³ ; Ziai SA⁷ ; Casanova JL^{8, 9, 10, 11} ; Mansouri D^{3, 12} Show Affiliations
Source: International Archives of Allergy and Immunology Published:2023

Abstract

Introduction: Cytokine storm and critical COVID-19 pneumonia are caused in at least 10% of patients by inborn errors of or auto-Abs to type I IFNs. The pathogenesis of life-threatening COVID-19 pneumonia in other patients remains unknown. Methods: This study was conducted at Masih Daneshvari Hospital, Tehran, Iran. In the period of study, 75 confirmed cases of COVID-19 with presentations ranging from mild upper respiratory tract infection to lower respiratory tract infection, including moderate, severe, and critical disease, were recruited. Expression of STING mRNA was measured in peripheral blood mononuclear cells (PBMCs) and compared between patients with different severity and outcome. Results: There was a significant negative correlation between age and STING expression level (p value = 0.010). Patients with severe to criticalillness had a 20-fold lower STING expression level compared to the mild to moderategroup (p value = 0.001). Also, the results showed lower expressions of STING in the patients admitted to the ICU (p value = 0.015). Patients who finally died had lower expression of STING at the time of sampling (p value = 0.041). Conclusion: STING mRNA expression in PBMCs was significantly lower in older COVID-19 cases, the patients with more severe illness, who needed intensive care, and who eventually died. © 2023 S. Karger AG. All rights reserved.