Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis

Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis Publisher

Monfaredan A¹ ; Motevaseli E¹ ; Tavoosidana G¹ ; Rahim F² ; Kozhobekov KG³ ; Modarressi MH⁴ ; Hosseininasab A⁵ ; Aghajaniafrouzi AA⁶ ; Sabet MS⁷

Source: Radioelektronika# Nanosistemy# Informacionnye Tehnologii Published:2024

Abstract

Exosomes, a small bilayer membrane derived from eukaryotic cells, have been identified as a useful natural delivery platform due to their suitable size, biocompatibility, structural stability, high loading capacity, and editable surface capability. Due to the difficulty of maintaining the highly pure exosome, several attempts have conducted the techniques for exosome isolation. In recent years, microstructures have found many applications in chemistry, biology, and medicine due to their high accuracy and low cost of materials. Soft lithography is a low-cost, fast, accurate, and yet widely used method of construction of Micron channels. In the present study, a soft lithography process has been performed to construct channels for exosome separation with immunoaffinity function. Both biochemical and biophysical categories tests were performed to examine the quality of extracted exosomes from different sources (serum, cell supernatant, and urine) and compared with the commercially available kit. Results showed that the current technique was capable to isolate exosomes with a high yield rate, purity, and low time consumption. All forms of the imatinib loaded exosomes exhibited the antitumor activity against KYO-1 cell line. © 2024 Russian Academy of Natural Science. All rights reserved.

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Style	Citing Format
MLA	Monfaredan A, et al.. "Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis." Radioelektronika# Nanosistemy# Informacionnye Tehnologii, vol. 16, no. 2, 2024, pp. 223-238.
APA	Monfaredan A, Motevaseli E, Tavoosidana G, Rahim F, Kozhobekov KG, Modarressi MH, Hosseininasab A, Aghajaniafrouzi AA, Sabet MS (2024). Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis. Radioelektronika# Nanosistemy# Informacionnye Tehnologii, 16(2), 223-238.
Chicago	Monfaredan A, Motevaseli E, Tavoosidana G, Rahim F, Kozhobekov KG, Modarressi MH, Hosseininasab A, Aghajaniafrouzi AA, Sabet MS. "Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis." Radioelektronika# Nanosistemy# Informacionnye Tehnologii 16, no. 2 (2024): 223-238.
Harvard	Monfaredan A et al. (2024) 'Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis', Radioelektronika# Nanosistemy# Informacionnye Tehnologii, 16(2), pp. 223-238.
Vancouver	Monfaredan A, Motevaseli E, Tavoosidana G, Rahim F, Kozhobekov KG, Modarressi MH, et al.. Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis. Radioelektronika# Nanosistemy# Informacionnye Tehnologii. 2024;16(2):223-238.
BibTex	@article{ author = {Monfaredan A and Motevaseli E and Tavoosidana G and Rahim F and Kozhobekov KG and Modarressi MH and Hosseininasab A and Aghajaniafrouzi AA and Sabet MS}, title = {Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis}, journal = {Radioelektronika# Nanosistemy# Informacionnye Tehnologii}, volume = {16}, number = {2}, pages = {223-238}, year = {2024} }
RIS	TY - JOUR AU - Monfaredan A AU - Motevaseli E AU - Tavoosidana G AU - Rahim F AU - Kozhobekov KG AU - Modarressi MH AU - Hosseininasab A AU - Aghajaniafrouzi AA AU - Sabet MS TI - Designing a Microchip for Exosome Isolation With the Ability to Simultaneously Impregnate It With Imatinib: An in Vitro Analysis JO - Radioelektronika# Nanosistemy# Informacionnye Tehnologii VL - 16 IS - 2 SP - 223 EP - 238 PY - 2024 ER -

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