Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study

Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study Publisher Pubmed

Haghbin M¹ ; Malekshah RE² ; Sobhani M³ ; Izadi Z³ ; Haghshenas B⁴ ; Ghasemi M⁵ ; Kalani BS⁶ ; Samadian H³

Show Affiliations

1. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Medical Biomaterial Research Centre (MBRC), Tehran University of Medical Sciences, Tehran, Iran
3. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4. Regenerative Medicine Research Center (RMRC), Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, 67146, Iran
5. Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
6. Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran

Source: International Journal of Biological Macromolecules Published:2023

Abstract

The main purpose of this study is to synthesize and characterize Persian gum-based hydrogel composited with gentamicin (Gen)-loaded natural zeolite (Clinoptilolite) and to evaluate its biological properties. Clinoptilolite (CLN) was decorated with Gen, and the conjugation was confirmed using computational and experimental assessments. The Monte Carlo adsorption locator module was used to reveal the physicochemical nature of the adsorption processes of Gen on CLN and ALG and gum on Gen@ CLN in Materials Studio 2017 software. Based on the high negative results, the adsorption process was found to be endothermic in all studied cases, and the interaction energies were in the range of physisorption for Gen on CLN and ALG and gum on Gen@CLN. Dynamic light scattering (DLS) and zeta potential analysis showed that the size of pristine CLN was around 2959 nm and the conjugation decreased the size significantly to approximately 932 nm. The hydrogel characterizations showed that the Gen-decorated CLNs are homogenously dispersed into the hydrogel matrix, and the resultant hydrogels have a porous structure with interconnected pores. The release kinetics evaluation showed that around 80 % of Gen was released from the nanocomposite drug during the first 10 h. In vitro studies revealed hemocompatibility and cytocompatibility of the nanocomposite. Microbial assessments indicated dose-dependent antibacterial activity of the hydrogel against gram (+) and gram (−) bacteria. The results showed that the fabricated hydrogel nanocomposite exhibits favorable physicochemical and biological properties. © 2023 Elsevier B.V.

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Style	Citing Format
MLA	Haghbin M, et al.. "Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study." International Journal of Biological Macromolecules, vol. 235, no. , 2023, pp. -.
APA	Haghbin M, Malekshah RE, Sobhani M, Izadi Z, Haghshenas B, Ghasemi M, Kalani BS, Samadian H (2023). Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study. International Journal of Biological Macromolecules, 235(), -.
Chicago	Haghbin M, Malekshah RE, Sobhani M, Izadi Z, Haghshenas B, Ghasemi M, Kalani BS, Samadian H. "Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study." International Journal of Biological Macromolecules 235, no. (2023): -.
Harvard	Haghbin M et al. (2023) 'Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study', International Journal of Biological Macromolecules, 235(), pp. -.
Vancouver	Haghbin M, Malekshah RE, Sobhani M, Izadi Z, Haghshenas B, Ghasemi M, et al.. Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study. International Journal of Biological Macromolecules. 2023;235():-.
BibTex	@article{ author = {Haghbin M and Malekshah RE and Sobhani M and Izadi Z and Haghshenas B and Ghasemi M and Kalani BS and Samadian H}, title = {Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study}, journal = {International Journal of Biological Macromolecules}, volume = {235}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Haghbin M AU - Malekshah RE AU - Sobhani M AU - Izadi Z AU - Haghshenas B AU - Ghasemi M AU - Kalani BS AU - Samadian H TI - Fabrication and Characterization of Persian Gum-Based Hydrogel Loaded With Gentamicin-Loaded Natural Zeolite: An in Vitro and in Silico Study JO - International Journal of Biological Macromolecules VL - 235 IS - SP - EP - PY - 2023 ER -

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