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A Promising Wound Dressing Based on Alginate Hydrogels Containing Vitamin D3 Cross-Linked by Calcium Carbonate/D-Glucono-Δ-Lactone Publisher



Ehterami A1 ; Salehi M2, 3 ; Farzamfar S4 ; Samadian H5 ; Vaez A6 ; Sahrapeyma H7 ; Ghorbani S8, 9
Authors
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Authors Affiliations
  1. 1. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  3. 3. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  4. 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
  8. 8. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  9. 9. Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark

Source: Biomedical Engineering Letters Published:2020


Abstract

In the present study, we fabricated vitamin D3-loaded alginate hydrogel and assessed its wound healing capability in the animal model. The various concentrations of vitamin D3 were added to the pre-dissolved sodium alginate in deionized water and cross-linked by calcium carbonate in combination with d-glucono-δ-lactone. The microstructure, swelling behavior, weight loss, hemo- and cytocompatibility of the fabricated hydrogels were evaluated. In the last stage, the therapeutic efficacy of the prepared hydrogels was evaluated in the full-thickness dermal wound model. The scanning electron microscopy images showed that the prepared hydrogel was highly porous with the porosity of 89.2 ± 12.5% and contained the interconnected pores. Weight loss assessment showed that the prepared hydrogel is biodegradable with the weight loss percentage of about 89% in 14 days. The results showed that the prepared hydrogels were hemo- and cytocompatible. The animal study results implied that alginate hydrogel/3000 IU vitamin D3 group exhibited the highest wound closure present which was statistically significant than the control group (p < 0.05). Moreover, the histological examinations revealed that hydrogel containing 3000 IU vitamin D3 had the best performance and induced the highest re-epithelialization and granular tissue formation. All in all, this study suggests that alginate hydrogels with 3000 IU vitamin D3 can be exploited as a potential wound dressing in skin tissue engineering. © 2020, Korean Society of Medical and Biological Engineering.
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