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Effect of Orlistat on Serum Uric Acid Level in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Publisher Pubmed



Noori S1 ; Mirzababaei A1 ; Amini MR2 ; Clark CCT3 ; Mirzaei K1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Clinical Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Centre for Intelligent Healthcare, Coventry University, Coventry, United Kingdom

Source: International Journal of Clinical Practice Published:2021


Abstract

Objective: Hyperuricemia increases the risk of gout and cardiovascular diseases. Obesity increases the risk of hyperuricemia while weight loss (>5 kg) has been reported to decrease urate. The effects of orlistat on serum uric acid (SUA) are still controversial. The aim of this meta-analysis was to evaluate the influence of orlistat on SUA levels in adults. Methods: Relevant studies, published up to May 2020, were searched systematically through PubMed/Medline, Scopus and Google Scholar. All relevant randomised controlled clinical trials were included. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis and meta-regression were also carried out. Results: Overall 7 trials (9 datasets) that enrolled 1786 subjects were included. Orlistat showed in a significant change in SUA level (Difference in means: −17.661 μmol, 95% CI: −31.615 to −3.707, P =.01). A low heterogeneity observed across the studies (I2 = 25.119%). After categorising studies on the basis of duration and sample size, the effect of orlistat on SUA was significant. The results of meta-regression were showed that significant relationships were not found between orlistat and SUA in the duration of intervention. Conclusion: We found a significant reduction in SUA following orlistat therapy in adults. © 2021 John Wiley & Sons Ltd
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