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Association Between Micrornas and Chemoresistance in Pancreatic Cancer: Current Knowledge, New Insights, and Forthcoming Perspectives Publisher Pubmed



Rahnama N1 ; Jahangir M2 ; Alesaeid S3 ; Kahrizi MS4 ; Adili A5, 6 ; Mohammed RN7, 8 ; Aslaminabad R9 ; Akbari M9 ; Ozgonul AM10
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine and Health Services, Semnan University of Medical Sciences, Semnan, Iran
  2. 2. Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Internal Medicine and Rheumatology, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Senior Adult Oncology Department, Moffitt Cancer Center, University of South Florida, FL, United States
  6. 6. Department of Oncology, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Medical Laboratory Analysis Department, College of Health Sciences, Cihan University of Sulaimaniya, Kurdistan Region, Iraq
  8. 8. College of Veterinary Medicine, University of Sulaimani, Sulaimaniyah, Iraq
  9. 9. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Department of Biochemistry, Faculty of Medicine, Ege University, Izmir, Bornova, Turkey

Source: Pathology Research and Practice Published:2022


Abstract

Pancreatic duct adenocarcinoma, commonly known as pancreatic cancer (PC), is a cancer-related cause of death due to delayed diagnosis, metastasis, and drug resistance. Patients with PC suffer from incorrect responses to chemotherapy due to inherent and acquired chemical resistance. Numerous studies have shown the mechanism of the effect of chemoresistance on PC, such as genetic and epigenetic changes or the elucidation of signaling pathways. In this regard, microRNAs (miRNAs) have been identified as essential modulators of gene expression in various cellular functions, including chemoresistance. Thus, identifying the underlying link between microRNAs and PC chemoresistance helps determine the exact pathogenesis of PC. This study aims to classify miRNAs and signaling pathways related to PC chemoresistance, suggesting new therapeutic approaches to overcome PC chemoresistance. © 2022
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