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Critical Role of the Long Non-Coding Rnas (Lncrnas) in Radiotherapy (Rt)-Resistance of Gastrointestinal (Gi) Cancer: Is There a Way to Defeat This Resistance? Publisher



Tashakori N1 ; Kolour SSP2 ; Ghafouri K3 ; Ahmed SI4 ; Kahrizi MS5 ; Gerami R6 ; Altafi M7 ; Nazari A8
Authors
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Authors Affiliations
  1. 1. Department of Internal Medicine, Faculty of Medicine, Tehran branch, Islamic Azad University, Tehran, Iran
  2. 2. Radiology Department, Faculty of Medicine, Guilan University of Medical, Rasht, Iran
  3. 3. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anesthesia Techniques, Al-Noor University College, Nineveh, Iraq
  5. 5. Alborz University of Medical Sciences, Alborz, Karaj, Iran
  6. 6. Department of Radiology, Faculty of Medicine, AJA University of Medical Science, Tehran, Iran
  7. 7. Department of Radiology, Faculty of Biological Science and Technology, Shiraz Pardis Branch, Islamic Azad University, Shiraz, Iran
  8. 8. Department of Genetics, Faculty of Basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran

Source: Pathology Research and Practice Published:2024


Abstract

Radiotherapy (RT) is a frequently used treatment for cervical cancer, effectively decreasing the likelihood of the disease returning in the same area and extending the lifespan of individuals with cervical cancer. Nevertheless, the primary reason for treatment failure in cancer patients is the cancer cells' resistance to radiation therapy (RT). Long non-coding RNAs (LncRNAs) are a subset of RNA molecules that do not code for proteins and are longer than 200 nucleotides. They have a significant impact on the regulation of gastrointestinal (GI) cancers biological processes. Recent research has shown that lncRNAs have a significant impact in controlling the responsiveness of GI cancer to radiation. This review provides a concise overview of the composition and operation of lncRNAs as well as the intricate molecular process behind radiosensitivity in GI cancer. Additionally, it compiles a comprehensive list of lncRNAs that are linked to radiosensitivity in such cancers. Furthermore, it delves into the potential practical implementation of these lncRNAs in modulating radiosensitivity in GI cancer. © 2024
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