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Cigarette Smoking and Gastric Cancer in the Stomach Cancer Pooling (Stop) Project Publisher Pubmed



Praud D1 ; Rota M2 ; Pelucchi C2 ; Bertuccio P1 ; Rosso T1 ; Galeone C2 ; Zhang ZF5 ; Matsuo K11 ; Ito H12 ; Hu J13 ; Johnson KC15 ; Yu GP14 ; Palli D3 ; Ferraroni M1 Show All Authors
Authors
  1. Praud D1
  2. Rota M2
  3. Pelucchi C2
  4. Bertuccio P1
  5. Rosso T1
  6. Galeone C2
  7. Zhang ZF5
  8. Matsuo K11
  9. Ito H12
  10. Hu J13
  11. Johnson KC15
  12. Yu GP14
  13. Palli D3
  14. Ferraroni M1
  15. Muscat J9
  16. Lunet N17, 18
  17. Peleteiro B17, 18
  18. Malekzadeh R19
  19. Ye W20
  20. Song H20
  21. Zaridze D22
  22. Maximovitch D22
  23. Aragones N23, 24, 25
  24. Castanovinyals G26, 27, 28
  25. Vioque J26, 29
  26. Navarretemunoz EM26, 29
  27. Pakseresht M16, 19, 31
  28. Pourfarzi F19, 30
  29. Wolk A21
  30. Orsini N21
  31. Bellavia A21
  32. Hakansson N21
  33. Mu L7
  34. Pastorino R4
  35. Kurtz RC8
  36. Derakhshan MH19, 32
  37. Lagiou A33
  38. Lagiou P10, 34
  39. Boffetta P9
  40. Boccia S4, 6, 35
  41. Negri E2
  42. La Vecchia C1
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Sciences and Community Health, University of Milan, Italy
  2. 2. Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Via Giuseppe La Masa 19, Milan, 20156, Italy
  3. 3. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Istituto per Lo Studio e la Prevenzione Oncologica (ISPO), Florence, Italy
  4. 4. Section of Hygiene, Institute of Public Health, Universita Cattolica Del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Italy
  5. 5. Department of Epidemiology, UCLA Fielding School of Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, CA, United States
  6. 6. IRCCS SAN RAFFAELE PI SANA, Rome, Italy
  7. 7. Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, United States
  8. 8. Department of Medicine, Memorial Sloan Kettering Cancer Centre, United States
  9. 9. Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY, United States
  10. 10. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  11. 11. Division of Molecular Medicine, United States
  12. 12. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
  13. 13. Harbin Medical University, Harbin, China
  14. 14. Medical Informatics Center, Peking University, Peking, China
  15. 15. Department of Epidemiology and Community Health, University of Ottawa, Ottawa, ON, Canada
  16. 16. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Canada
  17. 17. EPIUnit - Institute of Public Health, University of Porto (ISPUP), Portugal
  18. 18. Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal
  19. 19. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  20. 20. Department of Medical Epidemiology and Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  21. 21. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  22. 22. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russian Federation
  23. 23. Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Spain
  24. 24. CIBER Epidemiologia y Salud Publica (CIBERESP), Spain
  25. 25. Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro, Madrid, Spain
  26. 26. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Spain
  27. 27. IMIM (Hospital Del Mar Medical Research Institute), Spain
  28. 28. Universitat Pompeu Fabra (UPF), Barcelona, Spain
  29. 29. Department of Public Health, Miguel Hernandez University, Campus San Juan, Alicante, Spain
  30. 30. Department of Community Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
  31. 31. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
  32. 32. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
  33. 33. Department of Public Health and Community Health, School of Health Professions, Athens Technological Educational Institute, Greece
  34. 34. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
  35. 35. ICAHN School of Medicine at Mount Sinai, New York, United States

Source: European Journal of Cancer Prevention Published:2018


Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the 'Stomach cancer Pooling (StoP) Project', including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09-1.32) for ever, 1.12 (95% CI: 0.99-1.27) for former, and 1.25 (95% CI: 1.11-1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10-1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14-1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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