Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium

Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium Publisher Pubmed

Rota M^{1, 2} ; Alicandro G^{2, 3} ; Pelucchi C² ; Bonzi R² ; Bertuccio P^{2, 4} ; Hu J⁵ ; Zhang ZF⁶ ; Johnson KC⁷ ; Palli D⁸ ; Ferraroni M² ; Yu GP⁹ ; Galeone C² ; Lopezcarrillo L¹⁰ ; Muscat J¹¹ Show All Authors

Rota M^{1, 2}
Alicandro G^{2, 3}
Pelucchi C²
Bonzi R²
Bertuccio P^{2, 4}
Hu J⁵
Zhang ZF⁶
Johnson KC⁷
Palli D⁸
Ferraroni M²
Yu GP⁹
Galeone C²
Lopezcarrillo L¹⁰
Muscat J¹¹
Lunet N^{12, 13}
Ferro A¹³
Ye W¹⁴
Plymoth A¹⁴
Malekzadeh R¹⁵
Zaridze D¹⁶
Maximovitch D¹⁶
Kogevinas M^{17, 18, 19, 20}
Fernandez De Larrea N^{17, 21}
Vioque J^{17, 22}
Navarretemunoz EM^{17, 22}
Tsugane S²³
Hamada GS²⁴
Hidaka A²³
Pakseresht M^{15, 25, 26}
Wolk A²⁷
Hakansson N²⁷
Hernandezramirez RU^{10, 28}
Lopezcervantes M²⁹
Ward M³⁰
Pourfarzi F^{15, 31}
Mu L³²
Kurtz RC³³
Lagiou A³⁴
Lagiou P^{35, 36}
Boffetta P^{37, 38}
Boccia S^{39, 40}
Negri E⁴
La Vecchia C²

Show Affiliations

1. Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy
2. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
3. Italian National Institute of Statistics, Rome, Italy
4. Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy
5. Harbin Medical University, Harbin, China
6. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, United States
7. School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, ON, Canada
8. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy
9. Medical Informatics Center, Peking University, Peking, China
10. Mexico National Institute of Public Health, Morelos, Mexico
11. Department of Public Health Sciences, Tobacco Center of Regulatory Science, Penn Sylvania State University College of Medicine, Hershey, PA, United States
12. Departamento de Ciencias da Saude Publica e Forenses e Educacao Medica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
13. EPIUnit â€“ Instituto de Saude Publica, Universidade do Porto, Porto, Portugal
14. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
15. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
16. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russian Federation
17. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain
18. ISGlobal, Barcelona, Spain
19. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
20. Universitat Pompeu Fabra (UPF), Barcelona, Spain
21. Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Carlos III Health Institute, Madrid, Spain
22. Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Alicante, Spain
23. Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan
24. Nikkei Disease Prevention Center, Sao Paulo, Brazil
25. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
26. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
27. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
28. Department of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, CT, United States
29. Direccion General de Planeacion y Desarrollo en Salud, Secretaria de Salud, Benito Juarez, Mexico
30. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States
31. Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
32. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States
33. Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, United States
34. Department of Public and Community Health, School of Health Sciences, University of West Attica, Egaleo, Greece
35. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
36. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
37. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
38. Department of Medical and Surgical Sciences, University of Bologna, Italy
39. Sezione di Igiene, Istituto di Sanita Pubblica, Universita Cattolica del Sacro Cuore, Roma, Italy
40. Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma, Italy

Source: International Journal of Cancer Published:2020

Abstract

Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. Our study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the “Stomach cancer Pooling (StoP) Project”. Educational level and household income were used as proxies for the SEP. We estimated pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) across levels of education and household income by pooling study-specific ORs through random-effects meta-analytic models. The relative index of inequality (RII) was also computed. A total of 9,773 GC cases and 24,373 controls from 25 studies from Europe, Asia and America were included. The pooled OR for the highest compared to the lowest level of education was 0.60 (95% CI, 0.44–0.84), while the pooled RII was 0.45 (95% CI, 0.29–0.69). A strong inverse association was observed both for noncardia (OR 0.39, 95% CI, 0.22–0.70) and cardia GC (OR 0.47, 95% CI, 0.22–0.99). The relation was stronger among H. pylori negative subjects (RII 0.14, 95% CI, 0.04–0.48) as compared to H. pylori positive ones (RII 0.29, 95% CI, 0.10–0.84), in the absence of a significant interaction (p = 0.28). The highest household income category showed a pooled OR of 0.65 (95% CI, 0.48–0.89), while the corresponding RII was 0.40 (95% CI, 0.22–0.72). Our collaborative pooled-analysis showed a strong inverse relationship between SEP indicators and GC risk. Our data call for public health interventions to reduce GC risk among the more vulnerable groups of the population. © 2019 UICC

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Reza Malekzadeh (24)

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Style	Citing Format
MLA	Rota M, et al.. "Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium." International Journal of Cancer, vol. 146, no. 3, 2020, pp. 671-681.
APA	Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang ZF, Johnson KC, Palli D, Ferraroni M, Yu GP, Galeone C, Lopezcarrillo L, Muscat J, Lunet N, Ferro A, Ye W, Plymoth A, Malekzadeh R, ... La Vecchia C (2020). Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium. International Journal of Cancer, 146(3), 671-681.
Chicago	Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang ZF, et al.. "Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium." International Journal of Cancer 146, no. 3 (2020): 671-681.
Harvard	Rota M et al. (2020) 'Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium', International Journal of Cancer, 146(3), pp. 671-681.
Vancouver	Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, et al.. Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium. International Journal of Cancer. 2020;146(3):671-681.
BibTex	@article{ author = {Rota M and Alicandro G and Pelucchi C and Bonzi R and Bertuccio P and Hu J and Zhang ZF and Johnson KC and Palli D and Ferraroni M and Yu GP and Galeone C and Lopezcarrillo L and Muscat J and Lunet N and Ferro A and Ye W and Plymoth A and Malekzadeh R and Zaridze D and Maximovitch D and Kogevinas M and Fernandez De Larrea N and Vioque J and Navarretemunoz EM and Tsugane S and Hamada GS and Hidaka A and Pakseresht M and Wolk A and Hakansson N and Hernandezramirez RU and Lopezcervantes M and Ward M and Pourfarzi F and Mu L and Kurtz RC and Lagiou A and Lagiou P and Boffetta P and Boccia S and Negri E and La Vecchia C}, title = {Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium}, journal = {International Journal of Cancer}, volume = {146}, number = {3}, pages = {671-681}, year = {2020} }
RIS	TY - JOUR AU - Rota M AU - Alicandro G AU - Pelucchi C AU - Bonzi R AU - Bertuccio P AU - Hu J AU - Zhang ZF AU - Johnson KC AU - Palli D AU - Ferraroni M AU - Yu GP AU - Galeone C AU - Lopezcarrillo L AU - Muscat J AU - Lunet N AU - Ferro A AU - Ye W AU - Plymoth A AU - Malekzadeh R AU - Zaridze D AU - Maximovitch D AU - Kogevinas M AU - Fernandez De Larrea N AU - Vioque J AU - Navarretemunoz EM AU - Tsugane S AU - Hamada GS AU - Hidaka A AU - Pakseresht M AU - Wolk A AU - Hakansson N AU - Hernandezramirez RU AU - Lopezcervantes M AU - Ward M AU - Pourfarzi F AU - Mu L AU - Kurtz RC AU - Lagiou A AU - Lagiou P AU - Boffetta P AU - Boccia S AU - Negri E AU - La Vecchia C TI - Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium JO - International Journal of Cancer VL - 146 IS - 3 SP - 671 EP - 681 PY - 2020 ER -

Style

Citing Format

MLA

Rota M, et al.. "Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium." International Journal of Cancer, vol. 146, no. 3, 2020, pp. 671-681.

APA

Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang ZF, Johnson KC, Palli D, Ferraroni M, Yu GP, Galeone C, Lopezcarrillo L, Muscat J, Lunet N, Ferro A, Ye W, Plymoth A, Malekzadeh R, ... La Vecchia C (2020). Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium. International Journal of Cancer, 146(3), 671-681.

Chicago

Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, Zhang ZF, et al.. "Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium." International Journal of Cancer 146, no. 3 (2020): 671-681.

Harvard

Rota M et al. (2020) 'Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium', International Journal of Cancer, 146(3), pp. 671-681.

Vancouver

Rota M, Alicandro G, Pelucchi C, Bonzi R, Bertuccio P, Hu J, et al.. Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium. International Journal of Cancer. 2020;146(3):671-681.

BibTex

@article{ author = {Rota M and Alicandro G and Pelucchi C and Bonzi R and Bertuccio P and Hu J and Zhang ZF and Johnson KC and Palli D and Ferraroni M and Yu GP and Galeone C and Lopezcarrillo L and Muscat J and Lunet N and Ferro A and Ye W and Plymoth A and Malekzadeh R and Zaridze D and Maximovitch D and Kogevinas M and Fernandez De Larrea N and Vioque J and Navarretemunoz EM and Tsugane S and Hamada GS and Hidaka A and Pakseresht M and Wolk A and Hakansson N and Hernandezramirez RU and Lopezcervantes M and Ward M and Pourfarzi F and Mu L and Kurtz RC and Lagiou A and Lagiou P and Boffetta P and Boccia S and Negri E and La Vecchia C}, title = {Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium}, journal = {International Journal of Cancer}, volume = {146}, number = {3}, pages = {671-681}, year = {2020} }

RIS

TY - JOUR
AU - Rota M
AU - Alicandro G
AU - Pelucchi C
AU - Bonzi R
AU - Bertuccio P
AU - Hu J
AU - Zhang ZF
AU - Johnson KC
AU - Palli D
AU - Ferraroni M
AU - Yu GP
AU - Galeone C
AU - Lopezcarrillo L
AU - Muscat J
AU - Lunet N
AU - Ferro A
AU - Ye W
AU - Plymoth A
AU - Malekzadeh R
AU - Zaridze D
AU - Maximovitch D
AU - Kogevinas M
AU - Fernandez De Larrea N
AU - Vioque J
AU - Navarretemunoz EM
AU - Tsugane S
AU - Hamada GS
AU - Hidaka A
AU - Pakseresht M
AU - Wolk A
AU - Hakansson N
AU - Hernandezramirez RU
AU - Lopezcervantes M
AU - Ward M
AU - Pourfarzi F
AU - Mu L
AU - Kurtz RC
AU - Lagiou A
AU - Lagiou P
AU - Boffetta P
AU - Boccia S
AU - Negri E
AU - La Vecchia C
TI - Education and Gastric Cancer Risk—An Individual Participant Data Meta-Analysis in the Stop Project Consortium
JO - International Journal of Cancer
VL - 146
IS - 3
SP - 671
EP - 681
PY - 2020
ER -

Science Communicator Platform

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Abstract