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Impact of Microrna Variants on Pi3k/Akt Signaling in Triple-Negative Breast Cancer: Comprehensive Review Publisher Pubmed



Mehrtabar E1 ; Khalaji A2, 3 ; Pandeh M4 ; Farhoudian A5 ; Shafiee N6 ; Shafiee A7 ; Ojaghlou F2 ; Mahdavi P8 ; Soleymanigoloujeh M9, 10
Authors
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Authors Affiliations
  1. 1. Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
  5. 5. School of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  6. 6. Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Board-Certified Cardiologist, Rajaie Cardiovascular Medical and Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  9. 9. Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States
  10. 10. Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

Source: Medical Oncology Published:2024


Abstract

Breast cancer (BC) is a significant cause of cancer-related mortality, and triple-negative breast cancer (TNBC) is a particularly aggressive subtype associated with high mortality rates, especially among younger females. TNBC poses a considerable clinical challenge due to its aggressive tumor behavior and limited therapeutic options. Aberrations within the PI3K/AKT pathway are prevalent in TNBC and correlate with increased therapeutic intervention resistance and poor outcomes. MicroRNAs (miRs) have emerged as crucial PI3K/AKT pathway regulators influencing various cellular processes involved in TNBC pathogenesis. The levels of miRs, including miR-193, miR-4649-5p, and miR-449a, undergo notable changes in TNBC tumor tissues, emphasizing their significance in cancer biology. This review explored the intricate interplay between miR variants and PI3K/AKT signaling in TNBC. The review focused on the molecular mechanisms underlying miR-mediated dysregulation of this pathway and highlighted specific miRs and their targets. In addition, we explore the clinical implications of miR dysregulation in TNBC, particularly its correlation with TNBC prognosis and therapeutic resistance. Elucidating the roles of miRs in modulating the PI3K/AKT signaling pathway will enhance our understanding of TNBC biology and unveil potential therapeutic targets. This comprehensive review aims to discuss current knowledge and open promising avenues for future research, ultimately facilitating the development of precise and effective treatments for patients with TNBC. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
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