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Androgens' Role in Severity and Mortality Rates of Covid-19 Publisher Pubmed



Ataei A1 ; Derakhshan MM2 ; Razmjooie M3 ; Zare F4 ; Amiresmaeili H5 ; Salehi N6 ; Namakkoobi N7 ; Mirhosseini H8 ; Karim B9 ; Iravani S10
Authors
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Authors Affiliations
  1. 1. School of Medicine, Bam University of Medical Sciences, Bam, Iran
  2. 2. Student Research Committee, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
  3. 3. Nursing School, Islamic Azad University of Darab, Darab, Iran
  4. 4. Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
  5. 5. Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  8. 8. Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
  9. 9. Student Research Committee, Babol University of Medical Science, Babol, Iran
  10. 10. School of Paramedical Sciences, Yazd University of Medical Science, Yazd, Iran

Source: Hormone and Metabolic Research Published:2022


Abstract

By the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. This review aimed to assess the role of androgens in COVID-19 severity and mortality. Androgens increase expressions of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2), which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) were substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor drugs considerably modified COVID-19 symptoms. Androgen deprivation therapy also improved COVID-19 symptoms in prostate cancer: overall the role of androgens in severity of COVID-19 and its associated mortality seemed to be very important. So, more studies in variety of populations are required to define the absolute role of androgens. © 2022. Thieme. All rights reserved.
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