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Therapeutic Targets of Natural Products for the Management of Cardiovascular Symptoms of Coronavirus Disease 2019 Publisher Pubmed



Mohammadi Pour P1 ; Farzaei MH2 ; Soleiman Dehkordi E3 ; Bishayee A4 ; Asgary S5
Authors
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Authors Affiliations
  1. 1. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Medical Plants Research Center, Basic Health Science, Shahrekord University of Medical Science, Shahrekord, Iran
  4. 4. Lake Erie College of Osteopathic Medicine, Bradenton, FL, United States
  5. 5. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Phytotherapy Research Published:2021


Abstract

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first occurred in China in December 2019 and subsequently spread all over the world with cardiovascular, renal, and pulmonary symptoms. Therefore, recognizing and treating the cardiovascular sign and symptoms that caused by coronavirus disease 2019 (COVID-19) can be effective in reducing patient mortality. To control the COVID-19-related cardiovascular symptoms, natural products are considered one of the promising choices as complementary medicine. Scientists are struggling to discover new antiviral agents specific to this virus. In this review, the natural products for management of cardiovascular symptoms of COVID-19 are categorized into three groups: (a) natural products with an impact on angiotensin II type 1 receptor; (b) natural products that inhibit angiotensin-converting enzyme activity; and (c) natural products that mimic adenosine activity. All these natural products should undergo clinical investigations to test their efficacy, safety, and toxicity in the treatment of cardiovascular symptoms of COVID-19. This article summarizes agents with potential efficacy against COVID-19-related cardiovascular symptoms. © 2021 John Wiley & Sons Ltd.
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