Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Cardiovascular Complications of Covid-19 Among Pregnant Women and Their Fetuses: A Systematic Review Publisher



Yaghoobpoor S1 ; Fathi M1 ; Vakili K1 ; Tutunchian Z1 ; Dehghani M2 ; Bahrami A3 ; Hajibeygi R1 ; Eslami S4 ; Yaghoobpour T5 ; Hajiesmaeili M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Faculty of Medicine, Kashan University of Medical Science, Kashan, Iran
  4. 4. Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
  6. 6. Anesthesia and Critical Care Department, Critical Care Quality Improvement Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Clinical Medicine Published:2022


Abstract

Background: COVID-19 is a viral infectious disease leading to a spectrum of clinical complications, especially cardiovascular. Evidence shows that this infection can potentially accompany a worse outcome in pregnant women. Cardiovascular complications in mothers and their fetuses are reported by previous studies. Objective: In this systematic review, we aim to investigate the cardiovascular complications of COVID-19 during pregnancy in the mothers and fetus, according to the published literature. Method: We systematically searched the online databases of PubMed, Scopus, Web of Science, and Google Scholar, using relevant keywords up to April 2022. We included all observational studies reporting cardiovascular complications among COVID-19-affected pregnant women and their fetuses. Results: We included 74 studies containing 47582 pregnant COVID-19 cases. Pre-eclampsia, hypertensive disorders, cardiomyopathy, heart failure, myocardial infarction, thrombosis formation, alterations in maternal–fetal Doppler patterns, and maternal and fetal arrhythmia were reported as cardiovascular complications. The highest incidences of pre-eclampsia/eclampsia among COVID-19 pregnant cases, reported by studies, were 69% and 62%, and the lowest were 0.5% and 3%. The highest and lowest incidences of fetal bradycardia were 20% and 3%, and regarding fetal tachycardia, 5.4% and 1%, respectively. Conclusion: SARS-CoV-2 infection during pregnancy can potentially be associated with cardiovascular complications in the mother, particularly pre-eclampsia and heart failure. Moreover, SARS-CoV-2 infection during pregnancy can potentially cause cardiovascular complications in the fetus, particularly arrhythmia. © 2022 by the authors.
Related Docs
View other Related Docs
1. Covid-19 Disease During Pregnancy and Peripartum Period: A Cardiovascular Review, Current Problems in Cardiology (2022)
2. Prenatal and Clinical Characteristics of Pregnant Women Infected With Covid-19 in Yazd, Iran: A Multicenter Cross-Sectional Study, International Journal of Reproductive BioMedicine (2022)
3. New Corona Virus (Covid-19) Management in Pregnancy and Childbirth, Archives of Clinical Infectious Diseases (2020)
4. Evaluation of Maternal and Fetal Outcomes in Pregnant Women With Covid-19 Based on Different Trimesters, Advanced Biomedical Research (2023)
5. Covid‑19’S Effect in Pregnancy and Vertical Transmission: A Systematic Review, International Journal of Preventive Medicine (2024)
6. A Mini-Review on Cardiovascular and Hematological Complications of Covid-19, Coronaviruses (2021)
7. Impact of Covid-19 Infection on Neonatal Birth Outcomes, Journal of Tropical Pediatrics (2021)
8. A Review of Pathophysiological Mechanism, Diagnosis, and Treatment of Thrombosis Risk Associated With Covid-19 Infection, IJC Heart and Vasculature (2022)
Experts (# of related papers)
View all Related Experts
Azam Soleimani (5)
Minoo Movahedi (2)
Other Related Docs
9. Presentation and Outcome of Congenital Heart Disease During Covid-19 Pandemic: A Review, Current Problems in Cardiology (2022)
10. Different Prognosis Among Pregnant Patients With Covid-19 Infection, Journal of Isfahan Medical School (2020)
11. Bleeding Diathesis or Prothrombotic State, Which One Predict the Covid-19 Prognosis in Pregnancy?, Journal of Obstetrics, Gynecology and Cancer Research (2021)
12. Thrombotic Storm in Coronavirus Disease 2019: From Underlying Mechanisms to Its Management, Journal of Medical Microbiology (2022)
13. Nervous System Involvement in Covid-19: A Review of the Current Knowledge, Molecular Neurobiology (2021)
14. Laboratory Findings of Covid-19 Infection Are Conflicting in Different Age Groups and Pregnant Women: A Literature Review, Archives of Medical Research (2020)
15. Diagnosis and Treatment of Acute Myocardial Ischemia in Patients With Covid-19 Infection, Journal of Isfahan Medical School (2021)
16. Emerging Coronaviruses: First Sars, Second Mers and Third Sars-Cov-2. Epidemiological Updates of Covid-19, Infezioni in Medicina (2020)
17. A Review of Coronary Artery Thrombosis: A New Challenging Finding in Covid-19 Patients and St-Elevation Myocardial Infarction, Current Problems in Cardiology (2021)
18. Gastrointestinal and Renal Complications in Sars-Cov-2-Infected Patients: Role of Immune System, Scandinavian Journal of Immunology (2021)
19. The Effect of Coronavirus Disease Pandemic on Maternal and Neonatal Health: A Cohort Study From Isfahan, Iran, International Journal of Reproductive BioMedicine (2023)
20. Androgens' Role in Severity and Mortality Rates of Covid-19, Hormone and Metabolic Research (2022)
21. Nanobased Platforms for Diagnosis and Treatment of Covid-19: From Benchtop to Bedside, ACS Biomaterials Science and Engineering (2021)
22. Clinical Profile, Outcome and Management of Kidney Disease in Covid-19 Patients - a Narrative Review, European Review for Medical and Pharmacological Sciences (2022)
23. On-Admission Versus In-Hospital Thromboembolism Due to Covid-19 Infection. What Is the Particular Characteristic of Those With Early Thrombotic Events?, Advances in Respiratory Medicine (2021)
24. Mental Health and Fear of Covid-19 in Iranian Pregnant Women: A Multi-Center Study, Nursing and Midwifery Studies (2022)
25. Cardiac Involvement According to Echocardiographic Findings in Severe Coronavirus Disease 2019, ARYA Atherosclerosis (2021)
26. Association of Factor V Leiden Deficiency With Preeclampsia, Eclampsia in the Pregnant Women, Journal of Babol University of Medical Sciences (2014)
27. Aspirin Administration From Early Pregnancy Versus Initiation After 11 Weeks of Gestation for Prevention of Pre-Eclampsia in Highrisk Pregnant Women: Study Protocol for Randomized Controlled Trial, International Journal of Reproductive BioMedicine (2024)
28. The Effect of a Positive Result of Covid Pcr Test in an Asymptomatic Pregnant Mother on the Weight and Apgar Score of Infants After Birth, Iranian Journal of Obstetrics, Gynecology and Infertility (2023)
29. Comprehensive Overview of Covid-19-Related Respiratory Failure: Focus on Cellular Interactions, Cellular and Molecular Biology Letters (2022)
30. A Narrative Literature Review on Traditional Medicine Options for Treatment of Corona Virus Disease 2019 (Covid-19), Complementary Therapies in Clinical Practice (2020)
31. A Study on the Effect of Aspirin on Clinical Symptoms, Laboratory Indices, and Outcomes in Patients With Covid-19, Journal of Nephropharmacology (2023)
32. Comparison of the Mean Level of C3 & C4 Complements in Pre-Eclamptic Patients and Normal Pregnancy, Journal of Isfahan Medical School (2007)
33. The Hearing Status of Infants Born to Mothers With a History of Covid-19 Disease in the Third Trimester of Pregnancy Compared to the Control Group, Journal of Isfahan Medical School (2023)
34. Remdesivir Prescription in Pregnant Women Infected With Covid-19: A Report of Compassionate Use, Advanced Biomedical Research (2023)
35. Risk Factors of Congenital Heart Diseases: A Hospital-Based Case-Control Study in Isfahan, Iran, ARYA Atherosclerosis (2020)
36. The Rate of Bleeding During Cesarean Section in Pregnant Women With Covid-19 Admitted to Hospitals in Tabriz, 2021, Iranian Journal of Obstetrics, Gynecology and Infertility (2022)
37. Meta-Analysis of Cardiovascular Events and Related Biomarkers Comparing Survivors Versus Non-Survivors in Patients With Covid-19, American Journal of Cardiology (2020)
38. Information Needs of Pregnant Women in the Covid-19 Pandemic From Experts’ Point of View: A Qualitative Study, International Journal of Community Based Nursing and Midwifery (2021)
39. Clinical Features and Risk Factors Associated With Acute Respiratory Distress Syndrome in Pregnant Women Diagnosed With Covid-19: A Multi-Center Case-Control Study, Journal of Maternal-Fetal and Neonatal Medicine (2022)
40. Opium and Tobacco Use, and Outcome in Covid-19 Infected Patients: A Cross-Sectional Study, International Journal of High Risk Behaviors and Addiction (2024)
41. Severe Covid-19 in a Postpartum Woman: A Three-Month Challenge With Convalescent Plasma and Corticosteroid, Frontiers in Emergency Medicine (2021)
42. Myocardial Perfusion Imaging in the Era of Covid-19: A Systematic Review, Clinical and Translational Imaging (2023)
43. Impact of Sars-Cov-2 Pandemic on Patients With Primary Immunodeficiency, Journal of Clinical Immunology (2021)
44. Cytokines and Micrornas in Sars-Cov-2: What Do We Know?, Molecular Therapy Nucleic Acids (2022)
45. Maternal and Neonatal Outcomes of Covid-19 Infection in Pregnancy, Archives of Iranian Medicine (2023)
46. A Review on the Genetic, Environmental, and Lifestyle Aspects of the Early-Life Origins of Cardiovascular Disease, Current Problems in Pediatric and Adolescent Health Care (2014)
47. Correlation of Expression of Mmp-2, Ace2, and Tmprss2 Genes With Lymphopenia for Mild and Severity of Covid-19, Iranian Journal of Allergy, Asthma and Immunology (2023)
48. Acute Cardiac Injury in Covid-19: A Systematic Review and Meta-Analysis, Archives of Iranian Medicine (2020)
49. Stem Cell Therapy Potency in Personalizing Severe Covid-19 Treatment, Stem Cell Reviews and Reports (2021)
50. Demographic, Clinical, and Para Clinical Features in Patients With Covid-19 and St-Elevation Myocardial Infarction; [ویژگیهای دموگرافیک، کلینیکی و پاراکلینیکی در بیماران مبتال به انفارکتوس میوکارد با صعود قطعهی St و بیماری کووید- 91], Journal of Isfahan Medical School (2023)