Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Chitosan/Graphene and Poly(D, L-Lactic-Co-Glycolic Acid)/Graphene Nano-Composites for Nerve Tissue Engineering Publisher



Soltani S1 ; Ebrahimianhosseinabadi M1, 3 ; Zargar Kharazi A2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  2. 2. Biomaterials and Tissue Engineering Group, Advanced Medical Technology Department, Isfahan University of Medical Science, Isfahan, Iran
  3. 3. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Azadi Sq., Isfahan, 81746-73441, Iran

Source: Tissue Engineering and Regenerative Medicine Published:2016


Abstract

This study aimed at examining and comparing the fabrication process, electrical conductivity, and biological properties of Chitosan/Graphene membranes and poly(D, L-lactic-co-glycolic acid) (PLGA)/Graphene membranes. Nano-composite membranes were made using chitosan or PLGA matrix, and 0.5–1.5 wt.% graphene nano-sheets as the reinforcement material; all the membranes were fabricated through solution casting method. Fourier transform infrared spectroscopy and X-ray diffraction results indicated that the graphene had been uniformly dispersed in polymeric matrix. The membranes with 1.5 wt.% graphene appeared to have the highest value of electrical conductivity among all the examined the membranes and this growth was about 106 in comparison with neat polymers. Since the Chitosan 1.5% graphene membrane was found to have the highest proliferation after 72 hours by MTT [3-(4, 5-di-methylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide] assay of PC12 cell line (p<0.05), it is promising to consider nano-composite membrane for nerve tissue engineering applications. © 2016, The Korean Tissue Engineering and Regenerative Medicine Society and Springer Science+Business Media Dordrecht.
Related Docs
View other Related Docs
1. Poly(Glycerol-Sebacate)/Poly(Caprolactone)/Graphene Nanocomposites for Nerve Tissue Engineering, Journal of Bioactive and Compatible Polymers (2018)
2. Evaluation of Physical, Mechanical, and Biodegradation of Chitosan/Graphene Oxide Composite As Bone Substitutes, Polymer-Plastics Technology and Materials (2020)
3. Nano-Featured Poly (Lactide-Co-Glycolide)-Graphene Microribbons As a Promising Substrate for Nerve Tissue Engineering, Composites Part B: Engineering (2019)
4. Fabrication and Characterization of Two-Layered Nanofibrous Membrane for Guided Bone and Tissue Regeneration Application, Materials Science and Engineering C (2017)
5. The Effects of a Novel Multicomponent Transition Metal Dichalcogenide on Nervous System Regeneration, Journal of Bionic Engineering (2022)
6. Biological Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate) Based Electrospun Nanocomposite Scaffolds for Cartilage Tissue Engineering Application, Materials Technology (2020)
7. A New Approach to Fabrication of Cs/Bg/Cnt Nanocomposite Scaffold Towards Bone Tissue Engineering and Evaluation of Its Properties, Applied Surface Science (2015)
8. Differential Effects of Rat Adscs Encapsulation in Fibrin Matrix and Combination Delivery of Bdnf and Gold Nanoparticles on Peripheral Nerve Regeneration, BMC Neuroscience (2021)
Experts (# of related papers)
View all Related Experts
Saeed Karbasi (19)
Shahnaz Razavi (6)
Other Related Docs
9. Effects of Multi-Wall Carbon Nanotubes on Structural and Mechanical Properties of Poly(3-Hydroxybutyrate)/Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering, Bulletin of Materials Science (2017)
10. Encapsulation of Drug-Loaded Graphene Oxide-Based Nanocarrier Into Electrospun Pullulan Nanofibers for Potential Local Chemotherapy of Breast Cancer, Macromolecular Chemistry and Physics (2021)
11. Fabrication and Characterization of Chitosan-Gelatin/Single-Walled Carbon Nanotubes Electrospun Composite Scaffolds for Cartilage Tissue Engineering Applications, Polymers for Advanced Technologies (2022)
12. Regeneration of Rat Sciatic Nerve Using Plga Conduit Containing Rat Adscs With Controlled Release of Bdnf and Gold Nanoparticles, Journal of Molecular Neuroscience (2021)
13. 3D Printed Polylactic Acid-Based Nanocomposite Scaffold Stuffed With Microporous Simvastatin-Loaded Polyelectrolyte for Craniofacial Reconstruction, International Journal of Biological Macromolecules (2024)
14. Novel Electrospun Polyvinyl Alcohol/Chitosan/Polycaprolactone-Diltiazem Hydrochloride Nanocomposite Membranes for Wound Dressing Applications, Emergent Materials (2024)
15. Polycaprolactone-Chitosan/Multi-Walled Carbon Nanotube: A Highly Strengthened Electrospun Nanocomposite Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2022)
16. Assessing the Physical and Mechanical Properties of Poly 3-Hydroxybutyrate-Chitosan-Multi-Walled Carbon Nanotube/Silk Nano-Micro Composite Scaffold for Long-Term Healing Tissue Engineering Applications, Micro and Nano Letters (2018)
17. Investigation of Physical, Mechanical and Biological Properties of Polyhydroxybutyrate-Chitosan/Graphene Oxide Nanocomposite Scaffolds for Bone Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
18. Mechanical Behaviour, Hybridisation and Osteoblast Activities of Novel Baghdadite/ Pcl-Graphene Nanocomposite Scaffold: Viability, Cytotoxicity and Calcium Activity, Materials Technology (2022)
19. Polyurethane Nanocomposite Impregnated With Chitosan-Modified Graphene Oxide As a Potential Antibacterial Wound Dressing, Materials Science and Engineering C (2020)
20. Electrospun Core-Shell Polycaprolactone/ Chitosan Nanofibrous Composite With Enhanced Curcumin Loading Capacity for Wound Healing Applications, Materials Today Chemistry (2024)
21. Polyglycerol Sebacate/Polycaprolactone/Reduced Graphene Oxide Composite Scaffold for Myocardial Tissue Engineering, Heliyon (2024)
22. Development of Novel Aligned Nanofibrous Composite Membranes for Guided Bone Regeneration, Journal of the Mechanical Behavior of Biomedical Materials (2013)
23. Evaluation of the Effects of Decellularized Extracellular Matrix Nanoparticles Incorporation on the Polyhydroxybutyrate/Nano Chitosan Electrospun Scaffold for Cartilage Tissue Engineering, International Journal of Biological Macromolecules (2024)
24. Chemofunctionalization of Knitted Silk to Improve Interface Connection in a Nano/Micro Scaffold Based on Polycaprolactone-Chitosan-Multi-Walled Carbon Nanotube/Silk, International Journal of Biological Macromolecules (2024)
25. Evaluation of the Structural Properties and Cellular Behavior of Electrospun Poly(Hydroxybutyrate)/Chitosan Blend Scaffolds for Cartilage Tissue Engineering, Journal of Isfahan Medical School (2015)
26. Recording of Electrophysiological Changes and Sensory Function by Conduit Containing Stem Cells, Gold Nanoparticles and Neurotrophic Factor After Sciatic Nerve Regeneration; [ثبت تغییرات الکتروفیسیولوشیک و عملکرد حسی توسط کاندویت حاوی سلولهای بنیادی، نانو ذرات طال و اکتور نوروتروفیک، پس از ترمیم آسیب عصب سیاتیک], Journal of Isfahan Medical School (2023)
27. Reduced Graphene Oxide–Reinforced Gellan Gum Thermoresponsive Hydrogels As a Myocardial Tissue Engineering Scaffold, Journal of Bioactive and Compatible Polymers (2019)
28. A Study on the Role of Multi-Walled Carbon Nanotubes on the Properties of Electrospun Poly(Caprolactone)/Poly(Glycerol Sebacate) Scaffold for Nerve Tissue Applications, Materials Chemistry and Physics (2022)
29. Biodegradation and Cellular Evaluation of Aligned and Random Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Nerve Tissue Engineering Applications, Materials Technology (2020)
30. Evaluation of the Effects of Glucosamine Sulfate on Poly(3- Hydroxybutyrate) -Chitosan/Carbon Nanotubes Electrospun Scaffold for Cartilage Tissue Engineering Applications, Polymer-Plastics Technology and Materials (2022)
31. Evaluation of Pcl/Chitosan Electrospun Nanofibers for Liver Tissue Engineering, International Journal of Polymeric Materials and Polymeric Biomaterials (2017)
32. Characterization of Plga/Chitosan Electrospun Nano-Biocomposite Fabricated by Two Different Methods, International Journal of Polymeric Materials and Polymeric Biomaterials (2015)
33. Beneficial Effects of Biodelivery of Brain-Derived Neurotrophic Factor and Gold Nanoparticles From Functionalized Electrospun Plga Scaffold for Nerve Tissue Engineering, Journal of Cluster Science (2021)
34. Biocompatible Graphene-Embedded Pcl/Pgs-Based Nanofibrous Scaffolds: A Potential Application for Cardiac Tissue Regeneration, Journal of Applied Polymer Science (2021)
35. Electro-Conductive Nanofibrous Structure Based on Pgs/Pcl Coated With Ppy by in Situ Chemical Polymerization Applicable As Cardiac Patch: Fabrication and Optimization, Journal of Applied Polymer Science (2022)
36. Fabrication and Characterization of Pcl/Gel Nanofibrous Scaffolds Incorporated With Graphene Oxide Applicable in Cardiac Tissue Engineering, Polymer-Plastics Technology and Materials (2021)
37. Physical, Mechanical and Biological Evaluation of Poly (3-Hydroxybutyrate)-Chitosan/Mwnts As a Novel Electrospun Scaffold for Cartilage Tissue Engineering Applications, Polymer-Plastics Technology and Materials (2020)
38. Evaluation of the Effects of Halloysite Nanotube on Polyhydroxybutyrate - Chitosan Electrospun Scaffolds for Cartilage Tissue Engineering Applications, International Journal of Biological Macromolecules (2023)
39. Evaluation of Sustained Ciprofloxacin Release of Biodegradable Electrospun Gelatin/Poly(Glycerol Sebacate) Mat Membranes for Wound Dressing Applications, Asia-Pacific Journal of Chemical Engineering (2018)
40. Evaluation of Physical, Mechanical and Biological Properties of Poly 3-Hydroxybutyrate-Chitosan-Multiwalled Carbon Nanotube/Silk Nano-Micro Composite Scaffold for Cartilage Tissue Engineering Applications, International Journal of Biological Macromolecules (2019)
41. Electrospun Ag-Decorated Reduced Go-Graft-Chitosan Composite Nanofibers With Visible Light Photocatalytic Activity for Antibacterial Performance, Chemosphere (2022)
42. Electrosprayed Cefazolin-Loaded Niosomes Onto Electrospun Chitosan Nanofibrous Membrane for Wound Healing Applications, Journal of Biomedical Materials Research - Part B Applied Biomaterials (2022)
43. Evaluation of the Effects of Hyaluronic Acid on Poly (3-Hydroxybutyrate)/Chitosan/Carbon Nanotubes Electrospun Scaffold: Structure and Mechanical Properties, Polymer-Plastics Technology and Materials (2019)