Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Exploiting New Strategies in Combating Head and Neck Carcinoma: A Comprehensive Review on Phytochemical Approaches Passing Through Pi3k/Akt/Mtor Signaling Pathway Publisher Pubmed



Iranpanah A1 ; Majnooni MB2 ; Biganeh H3 ; Amirian R2, 4 ; Rastegaripouyani M5 ; Filosa R6 ; Cheang WS7 ; Fakhri S1 ; Khan H8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Science and Technology, University of Sannio, Benevento, Italy
  7. 7. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
  8. 8. Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan

Source: Phytotherapy Research Published:2024


Abstract

Recently, malignant neoplasms have growingly caused human morbidity and mortality. Head and neck cancer (HNC) constitutes a substantial group of malignancies occurring in various anatomical regions of the head and neck, including lips, mouth, throat, larynx, nose, sinuses, oropharynx, hypopharynx, nasopharynx, and salivary glands. The present study addresses the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway as a possible therapeutic target in cancer therapy. Finding new multitargeting agents capable of modulating PI3K/Akt/mTOR and cross-linked mediators could be viewed as an effective strategy in combating HNC. Recent studies have introduced phytochemicals as multitargeting agents and rich sources for finding and developing new therapeutic agents. Phytochemicals have exhibited immense anticancer effects, including targeting different stages of HNC through the modulation of several signaling pathways. Moreover, phenolic/polyphenolic compounds, alkaloids, terpenes/terpenoids, and other secondary metabolites have demonstrated promising anticancer activities because of their diverse pharmacological and biological properties like antiproliferative, antineoplastic, antioxidant, and anti-inflammatory activities. The current review is mainly focused on new therapeutic strategies for HNC passing through the PI3K/Akt/mTOR pathway as new strategies in combating HNC. © 2024 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Mechanistic Insights Into Circrna-Mediated Regulation of Pi3k Signaling Pathway in Glioma Progression, Pathology Research and Practice (2024)
2. Pi3k/Akt/Mtor Signaling Pathway Modulation by Circular Rnas in Breast Cancer Progression, Pathology Research and Practice (2023)
3. Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways, Metabolites (2023)
4. A Bioinformatics Approach of Specificity Protein Transcription Factors in Head and Neck Squamous Cell Carcinoma, Research in Pharmaceutical Sciences (2024)
5. Synergistic Antitumor Effect of Nvp-Bez235 and Cape on Mda-Mb-231 Breast Cancer Cells, Biomedicine and Pharmacotherapy (2017)
6. Resveratrol As an Antitumor Agent for Glioblastoma Multiforme: Targeting Resistance and Promoting Apoptotic Cell Deaths, Acta Histochemica (2023)
7. Brain-Derived Neurotrophic Factor (Bdnf) As a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis, Brain and Behavior (2025)
8. The Potential Role of Circular Rnas -Regulated Pi3k Signaling in Non-Small Cell Lung Cancer: Molecular Insights and Clinical Perspective, Pathology Research and Practice (2024)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (2)
Maryam Yazdi (1)
Other Related Docs
9. Ultra-Processed Food Intake and Risk of Colorectal Cancer: A Matched Case-Control Study, Nutrition and Cancer (2023)
10. Hybrid Benzoxazole-Coumarin Compounds Induce Death Receptor-Mediated Switchable Apoptotic and Necroptotic Cell Death on Hn-5 Head and Neck Cancer Cell Line, Anti-Cancer Agents in Medicinal Chemistry (2016)
11. Expression Assay of Pten, Cdk4, and Mtor Genes and Cell Proliferation in Breast Cancer Cell Line (T47d) Under Grape Seed Extract Treatment, Journal of Isfahan Medical School (2022)
12. Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights Into Its Regulatory Mechanisms, Mini-Reviews in Medicinal Chemistry (2021)
13. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)
14. Exploring Stk3 in Melanoma: A Systematic Review of Signaling Networks and Therapeutic Opportunities, Molecular Biology Reports (2025)
15. Nanobodies; New Molecular Instruments With Special Specifications for Targeting, Diagnosis and Treatment of Triple-Negative Breast Cancer, Cancer Cell International (2022)
16. Flavonoids Target Different Molecules of Autophagic and Metastatic Pathways in Cancer Cells, Cancer Cell International (2023)
17. Potential Role of Thymoquinone to Treat Gastrointestinal Cancers: Insights Into Its Molecular Mechanisms, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
18. Recent Advances in Nanomaterials Development for Nanomedicine and Cancer, ACS Applied Bio Materials (2021)
19. Quercetin Modulates Signal Transductions and Targets Non-Coding Rnas Against Cancer Development, Cellular Signalling (2023)
20. Melatonin for Gastric Cancer Treatment: Where Do We Stand?, Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
21. Design, Synthesis, in Silico Studies, and Antiproliferative Evaluations of Novel Indolin-2-One Derivatives Containing 3-Hydroxy-4-Pyridinone Fragment, Bioorganic and Medicinal Chemistry Letters (2022)
22. The Landscape of Circrnas in Gliomas Temozolomide Resistance: Insights Into Molecular Pathways, Non-coding RNA Research (2024)
23. Purinergic Receptors Are a Key Bottleneck in Tumor Metabolic Reprogramming: The Prime Suspect in Cancer Therapeutic Resistance, Frontiers in Immunology (2022)
24. The Role of Dapk2 As a Key Regulatory Element in Various Human Cancers: A Systematic Review, Molecular Biology Reports (2024)
25. Targeting Glioma Cells With Nutraceuticals: Therapeutic Effects Based on Molecular Mechanisms, New Evidence and Perspectives, Mini-Reviews in Medicinal Chemistry (2023)
26. Unfavorable Prognosis and Clinical Consequences of Apobec3b Expression in Breast and Other Cancers: A Systematic Review and Meta-Analysis, Tumor Biology (2022)
27. Sar131675 Exhibits Anticancer Activity on Human Ovarian Cancer Cells Through Inhibition of Vegfr-3/Erk1/2/Akt Signaling Pathway, Cellular Signalling (2023)
28. Expression of Mtor/70S6k Signaling Pathway in Melanoma Cancer Cells and the Effects of Dacarbazine and Metformin, Current Cancer Therapy Reviews (2022)
29. Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance, Cell Death Discovery (2023)