Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Ph-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer Publisher Pubmed



Moammeri A1 ; Abbaspour K1 ; Zafarian A2 ; Jamshidifar E3 ; Motasadizadeh H3, 4 ; Dabbagh Moghaddam F5 ; Salehi Z1 ; Makvandi P6 ; Dinarvand R3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, 111554563, Iran
  2. 2. Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, 8174673461, Iran
  3. 3. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 141556451, Iran
  4. 4. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1316943551, Iran
  5. 5. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran
  6. 6. Istituto Italiano di Tecnologia, Center for Materials Interfaces, Pisa, 56025, Italy

Source: ACS Applied Bio Materials Published:2022


Abstract

Combination chemotherapy has become a treatment modality for breast cancer. However, serious side effects and high cytotoxicity associated with this combination therapy make it a high-risk method for breast cancer treatment. This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin (CIS) and epirubicin (EPI) in vitro (on SKBR3 and 4T1 breast cancer cells) and in vivo on BALB/c mice. For this purpose, polyethylene glycol (PEG) and folic acid (FA) were employed to prepare a functionalized niosomal system to improve endocytosis. FA-PEGylated niosomes exhibited desired encapsulation efficiencies of ∼91.2 and 71.9% for CIS and EPI, respectively. Moreover, cellular assays disclosed that a CIS and EPI-loaded niosome (NCE) and FA-PEGylated niosomal CIS and EPI (FPNCE) enhanced the apoptosis rate and cell migration in SKBR3 and 4T1 cells compared to CIS, EPI, and their combination (CIS+EPI). For FPNCE and NCE groups, the expression levels of Bax, Caspase3, Caspase9, and Mfn1 genes increased, whereas the expression of Bcl2, Drp1, MMP-2, and MMP-9 genes was downregulated. Histopathology results showed a reduction in the mitosis index, invasion, and pleomorphism in BALB/c inbred mice with NCE and FPNCE treatment. In this paper, for the first time, we report a niosomal nanocarrier functionalized with PEG and FA for codelivery of CIS and EPI to treat breast cancer. The results demonstrated that the codelivery of CIS and EPI through FA-PEGylated niosomes holds great potential for breast cancer treatment. © 2022 The Authors. Published by American Chemical Society
Related Docs
View other Related Docs
1. Dendrimers As Nanoscale Vectors: Unlocking the Bars of Cancer Therapy, Seminars in Cancer Biology (2022)
2. Advances in Aptamer-Based Drug Delivery Vehicles for Cancer Therapy, Biomaterials Advances (2022)
3. Gold Nanoparticles Loaded Into Niosomes: A Novel Approach for Enhanced Antitumor Activity Against Human Ovarian Cancer, Advanced Powder Technology (2021)
4. Msc-Derived Exosomes Enhance the Anticancer Activity of Drugs in 3D Spheroid of Breast Cancer Cells, Journal of Drug Delivery Science and Technology (2024)
5. Camouflaged Liposomes by 11A4-Nanobody for Co-Delivery of Cisplatin and Nitroxoline in Breast Cancer Tumors: An in Vitro/In Vivo Study, Journal of Drug Delivery Science and Technology (2022)
6. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
7. Antitumor Activity of Raloxifene-Targeted Poly(Styrene Maleic Acid)-Poly (Amide-Ether-Ester-Imide) Co-Polymeric Nanomicelles Loaded With Docetaxel in Breast Cancer-Bearing Mice, Investigational New Drugs (2018)
8. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (22)
Farshid Hassanzadeh (13)
Other Related Docs
9. In Vitro and in Vivo Evaluation of Novel Dtx-Loaded Multifunctional Heparin-Based Polymeric Micelles Targeting Folate Receptors and Endosomes, Recent Patents on Anti-Cancer Drug Discovery (2020)
10. Synthesis and in Vitro/In Vivo Characterization of Raloxifene Grafted Poly(Styrene Maleic Acid)-Poly(Amide-Ether-Ester-Imide) Micelles for Targeted Delivery of Docetaxel in G Protein-Coupled Estrogen Receptor Breast Cancer, Anti-Cancer Agents in Medicinal Chemistry (2018)
11. Co-Delivery of Dasatinib and Mir-30A by Liposomes Targeting Neuropilin-1 Receptors for Triple-Negative Breast Cancer Therapy, Journal of Materials Chemistry B (2024)
12. Ultrasound-Guided Chemoradiotherapy of Breast Cancer Using Smart Methotrexate-Loaded Perfluorohexane Nanodroplets, Nanomedicine: Nanotechnology, Biology, and Medicine (2023)
13. Blockade of Exosome Release Alters Her2 Trafficking to the Plasma Membrane and Gives a Boost to Trastuzumab, Clinical and Translational Oncology (2023)
14. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
15. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
16. Recent Progress in Cancer Immunotherapy: Application of Nano-Therapeutic Systems, Journal of Drug Delivery Science and Technology (2024)
17. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
18. Mitochondrial Characteristics Contribute to Proliferation and Migration Potency of Mda-Mb-231 Cancer Cells and Their Response to Cisplatin Treatment, Life Sciences (2020)
19. Multifunctional and Stimuli-Responsive Liposomes in Hepatocellular Carcinoma Diagnosis and Therapy, Translational Oncology (2024)
20. Investigation of Different Targeting Decorations Effect on the Radiosensitizing Efficacy of Albumin-Stabilized Gold Nanoparticles for Breast Cancer Radiation Therapy, European Journal of Pharmaceutical Sciences (2019)
21. Pharmacokinetics, Organ Toxicity and Antitumor Activity of Docetaxel Loaded in Folate Targeted Cholesterol Based Micelles, Current Drug Delivery (2016)
22. Pegylated Multifunctional Ph-Responsive Targeted Polymeric Micelles for Ovarian Cancer Therapy: Synthesis, Characterization and Pharmacokinetic Study, International Journal of Polymeric Materials and Polymeric Biomaterials (2021)
23. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
24. Cancer Stem Cells (Cscs): The Blockage of Metastatic and Stemness Properties by Metal Nanoparticles, Nanomedicine Research Journal (2021)
25. Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 As a Potential Selective Anti-Cancer Nano Platform, Journal of Inorganic and Organometallic Polymers and Materials (2023)
26. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
27. Anti-Cancer Effects of Nanoliposomes Containing Rosemary and Zataria Multiflora Boiss Essential Oils on Hepg2 Cell Line Under in Vitro Conditions, Journal of Babol University of Medical Sciences (2022)
28. The Effect of Folic Acid-Targeted Nanocarriers in Ultrasound Imaging-Guided Sonodynamic Therapy of Human Cervical Carcinoma (Hela): In Vitro Study, Koomesh (2023)
29. Nanobodies; New Molecular Instruments With Special Specifications for Targeting, Diagnosis and Treatment of Triple-Negative Breast Cancer, Cancer Cell International (2022)
30. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
31. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
32. Folate-Targeted Polyacrylamide/Punicic Acid Nanomicelles for Flutamide Delivery in Prostate Cancer: Characterization, in Vitro Biological Evaluation, and Its Dft Study, Recent Patents on Nanotechnology (2020)
33. Delivery of Vinblastine-Containing Niosomes Results in Potent in Vitro/In Vivo Cytotoxicity on Tumor Cells, Drug Development and Industrial Pharmacy (2018)
34. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
35. Microrna: A Novel Target of Curcumin in Cancer Therapy, Journal of Cellular Physiology (2018)
36. Biological Effects of Letrozole-Loaded Lipid Nanocapsules on Mcf-7 Cell Line, Journal of Isfahan Medical School (2013)
37. Uptake of Etoposide in Ct-26 Cells of Colorectal Cancer Using Folate Targeted Dextran Stearate Polymeric Micelles, BioMed Research International (2014)
38. Microfluidic Platforms in Diagnostic of Ovarian Cancer, Environmental Research (2023)
39. In Vitro Study of Sonodynamic Therapy Using Gemcitabine-Loaded Peg-Gold Nanoparticles Against Mcf-7 Breast Cancer Cells, BioNanoScience (2024)
40. Folic Acid Conjugated Nanoliposomes As Promising Carriers for Targeted Delivery of Bleomycin, Artificial Cells, Nanomedicine and Biotechnology (2018)
41. Immobilized Nanoparticles-Mediated Enzyme Therapy; Promising Way Into Clinical Development, Discover Nano (2023)
42. The Art of Design in Azlactone-Benzoxazinone Chemistry, Docking Studies and in Vitro Cytotoxicity Evaluation, Australian Journal of Chemistry (2022)
43. Hyaluronic Acid-Conjugated Gliadin Nanoparticles for Targeted Delivery of Usnic Acid in Breast Cancer: An in Vitro / in Vivo Translational Study, Journal of Drug Delivery Science and Technology (2023)
44. Sucrose Stearate Based Niosomes As an Alternative to Ordinary Vehicles for Efficient Curcumin Delivery, Journal of Food Measurement and Characterization (2022)
45. Platelet-Cloaked Alginate-Poly (Β-Amino Ester) a Novel Platform Bioinspired Polyelectrolyte Nanoparticle for Targeted Delivery of Carboplatin in Breast Cancer: An in Vitro/In Vivo Study, International Journal of Pharmaceutics (2024)
46. Trastuzumab and Folic Acid Functionalized Gold Nanoclusters As a Dual-Targeted Radiosensitizer for Megavoltage Radiation Therapy of Human Breast Cancer, European Journal of Pharmaceutical Sciences (2020)
47. Thermosensitive Folic Acid-Targeted Poly (Ethylene-Co-Vinyl Alcohol) Hemisuccinate Polymeric Nanoparticles for Delivery of Epirubicin to Breast Cancer Cells, Iranian Polymer Journal (English Edition) (2016)
48. Liposomal Azd5363 Displays Antiproliferation Activities and Induces Apoptosis on Y79 Retinoblastoma Cancer Cells, South Asian Journal of Cancer (2024)
49. Early Diagnosis of Breast and Ovarian Cancers by Body Fluids Circulating Tumor-Derived Exosomes, Cancer Cell International (2020)
50. Preparation, Characterization, and in Vitro Evaluation of Bleomycin-Containing Nanoliposomes, Chemical Biology and Drug Design (2017)