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The Effect of Antioxidant Vitamins E and C on Cognitive Performance of the Elderly With Mild Cognitive Impairment in Isfahan, Iran: A Double-Blind, Randomized, Placebo-Controlled Trial Publisher Pubmed



Alavi Naeini AM1 ; Elmadfa I2, 6 ; Djazayery A1 ; Barekatain M3 ; Aghaye Ghazvini MR4 ; Djalali M1 ; Feizi A5
Authors
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Authors Affiliations
  1. 1. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Institute of Nutritional Sciences, University of Vienna, Vienna, Austria
  3. 3. Department of Psychiatry and Behavioral Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Isfahan Center of Health Research, Nationally Institute of Health Research, Tehran University of Medical Science, Tehran, Iran
  5. 5. Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. International Union of Nutritional Sciences (IUNS), 1090 Vienna, Althanstrasse 14, Austria

Source: European Journal of Nutrition Published:2014


Abstract

Purpose: This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran. Methods: About 256 elderly with mild cognitive impairment, aged 60-75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year. Background: Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined. Results: Antioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively). Conclusion: Despite significant improvement in most of the oxidative stress biomarkers, antioxidants' supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected. © 2013 Springer-Verlag.
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