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The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques



Razavi S1 ; Nasresfahani MH2, 3, 4 ; Mardani M1
Authors
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Authors Affiliations
  1. 1. Anatomy Department, Faculty of Medicine, Isfahan Medical University, Iran
  2. 2. Embryology Department, Royan Institute, Tehran, Iran
  3. 3. Isfahan Fertility and Infertility Center, Royan Institute, Tehran, Iran
  4. 4. Embryology Department, Royan Institute, Tehran, P.O.Box: 19395-4644, Iran

Source: Yakhteh Published:2006

Abstract

Sperm DNA is known to contribute one half of the genomic material to the offspring. The integrity of sperm DNA is important in fertilization, embryonic and fetal development, and postnatal child well being. The nature has created multiple barriers that allow only the fittest sperm to reach and fertilize an oocyte. However, assisted reproductive techniques (ART), like IVF and ICSI, may allow sperms with abnormal genomic material to enter the oocyte with minimal effort. This article describes structure of sperm DNA and different mechanism involved in sperm chromatin anomalies and DNA damage. Furthermore, this study elaborates possible sperm selection methods that may improve the outcome of ART.
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Shahnaz Razavi (31)
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