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Antiviral Mechanisms of Curcumin and Its Derivatives in Prevention and Treatment of Covid-19: A Review Publisher Pubmed



Golpourhamedani S1 ; Pourmasoumi M2 ; Askari G3, 4 ; Bagherniya M3, 4 ; Majeed M5 ; Guest PC6, 7, 8 ; Sahebkar A9, 10, 11
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
  3. 3. Nutrition and Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Sabinsa Corporation, East Windsor, NJ, United States
  6. 6. Department of Psychiatry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
  7. 7. Laboratory of Translational Psychiatry, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
  8. 8. Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil
  9. 9. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  10. 10. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. School of Medicine, The University of Western Australia, Perth, Australia

Source: Advances in Experimental Medicine and Biology Published:2023


Abstract

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now plagued the world for almost 3 years. Although vaccines are now available, the severity of the pandemic and the current dearth of approved effective medications have prompted the need for novel treatment approaches. Curcumin, as a food nutraceutical with anti-inflammatory and antioxidant effects, is now under consideration for the prevention and treatment of COVID-19. Curcumin has been demonstrated to retard the entrance of SARS-CoV-2 into cells, interfere with its proliferation inside cells, and curb the hyperinflammatory state caused by the virus by modulating immune system regulators, minimizing the cytokine storm effect, and modulating the renin-angiotensin system. This chapter discusses the role of curcumin and its derivatives in the prevention and treatment of COVID-19 infection, considering the molecular mechanisms involved. It will also focus on the molecular and cellular profiling techniques as essential tools in this research, as these can be used in the identification and development of new biomarkers, drug targets, and therapeutic approaches for improved patient care. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
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