Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
G1359a Variant of the Cannabinoid Receptor Gene (Rs1049353) and Obesity-Related Traits and Related Endophenotypes: A Meta-Analysis Publisher Pubmed



Sadeghian M1, 2 ; Rahmani S3 ; Mansoori A1, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Nutrition, Para-Medical School, Ahvaz Jundishapur University of Medical Sciences, PO Box 61357-15794, Ahvaz, Khuzestan, Iran
  2. 2. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Community Nutrition, M.A. Graduate of Nutrition, School of Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Nutrition and Metabolic Diseases Research Center, Ahvaz Junishapur University of Medical Sciences, Ahvaz, Iran

Source: Annals of Nutrition and Metabolism Published:2018


Abstract

Background: This study aimed to investigate the comparison of G1359A variant of cannabinoid receptor gene (rs1049353) with obesity-related traits including body mass index (BMI), fat mass (FM), fat-free mass (FFM), food-related traits, and leptin among healthy and non-healthy adults. Methods: We searched PubMed, Cochrane, Scopus, Web of Science, and EMBASE until December 2016 for observational studies assessing each of the anthropometric measurements, food-related traits, and leptin of 1359 G/A polymorphism of CNR1 gene. A total of 22 studies were included in the meta-analysis comparing mean and SD differences of the anthropometric measurements, leptin, and dietary intake between GA/AA and GG genotypes. Results: The results showed that subjects with GA/AA genotype had significantly lower BMI (weighted mean difference = -0.59 kg/m2, p < 0.001) compared to those with the GG genotype. Dietary intake of fat, carbohydrate, and protein as well as serum levels of leptin was not significantly different between GA/AA and GG genotypes. Conclusion: It was revealed that subjects with mutant polymorphism (GA/AA) of CNR1, compared to the wild-type group (GG), had lower BMI (although there was unexplained heterogeneity). © 2018 S. Karger AG, Basel.
Related Docs
View other Related Docs
1. Adiponectin Gene Polymorphisms and Susceptibility to Atherosclerosis: A Meta-Analysis, Journal of Research in Medical Sciences (2013)
2. Dietary Phytochemical Index in Relation to Metabolic Health Status, Serum Adropin, and Brain-Derived Neurotrophic Factor Levels in Adults, Current Developments in Nutrition (2024)
3. Associations Between Fto Rs9939609 Polymorphism, Serum Vitamin D, Mental Health, and Eating Behaviors in Overweight Adults, Nutritional Neuroscience (2022)
4. Dietary Acid Load Adopts the Effect of Apob Ins/Del Genetic Variant (Rs11279109) on Obesity Trait, Cardiovascular Markers, Lipid Profile, and Serum Leptin Level Among Patients With Diabetes: A Cross-Sectional Study, Scientific Reports (2024)
5. Association of Single Nucleotide Polymorphisms in the First Intron of the Fat Mass and Obesity Associated (Fto) Gene With Obesity Risk in Asians: A Meta-Analysis, Progress in Nutrition (2019)
6. Dietary Intake of Branched-Chain Amino Acids in Relation to General and Abdominal Obesity, Eating and Weight Disorders (2022)
7. Ultra-Processed Foods Intake in Relation to Metabolic Health Status, Serum Brain-Derived Neurotrophic Factor and Adropin Levels in Adults, Nutrition Journal (2024)
8. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (4)
Shaghayegh Haghjooy Javanmard (4)
Other Related Docs
9. Interactions of Dietary Insulin Index and Dietary Insulin Load With Brain-Derived Neurotrophic Factor (Bdnf) Val66met Polymorphism in Relation to Cardiometabolic Markers in Iranian Diabetic Patients: A Cross-Sectional Study, British Journal of Nutrition (2022)
10. Dietary Quality Indices Modify the Effects of Apolipoprotein B Polymorphisms on Biochemical and Anthropometric Factors in Type 2 Diabetes Mellitus, Scientific Reports (2021)
11. Lipid Regulatory Genes Polymorphism in Children With and Without Obesity and Cardiometabolic Risk Factors: The Caspian-Iii Study, Journal of Research in Medical Sciences (2018)
12. Role of Rs9939506 Polymorphism of Fto Gene in Resistance to Eating in Male Adolescents, BMC Pediatrics (2023)
13. Association of Rs8066560 Variant in the Sterol Regulatory Element-Binding Protein 1 (Srebp-1) and Mir-33B Genes With Hyperglycemia and Insulin Resistance, Journal of Pediatric Endocrinology and Metabolism (2014)
14. Insulin and Leptin Levels in Overweight and Normal-Weight Iranian Adolescents: The Caspian-Iii Study, Journal of Research in Medical Sciences (2014)
15. Efficacy of a Comprehensive Weight Reduction Intervention in Male Adolescents With Different Fto Genotypes, Endocrinology, Diabetes and Metabolism (2024)
16. Alpha-Lipoic Acid Effect on Leptin and Adiponectin Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, European Journal of Clinical Pharmacology (2020)
17. Dietary Diversity Score and Obesity: A Systematic Review and Meta-Analysis of Observational Studies, European Journal of Clinical Nutrition (2016)
18. Dietary Intakes and Leptin Concentrations, ARYA Atherosclerosis (2014)
19. Association of Brain-Derived Neurotrophic Factor Gene Polymorphisms With Body Mass Index: A Systematic Review and Meta-Analysis, Advances in Medical Sciences (2018)
20. The Association Between Serum Omentin Level and Bodyweight: A Systematic Review and Meta-Analysis of Observational Studies, Clinical Nutrition ESPEN (2020)
21. Variants in the Ppargc1a Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate in Obese Women, Lipids (2018)
22. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)
23. The Influence of Fasting and Energy-Restricted Diets on Leptin and Adiponectin Levels in Humans: A Systematic Review and Meta-Analysis, Clinical Nutrition (2021)
24. Genetic Associations of the Visfatin G-948T Polymorphism With Obesity-Related Metabolic Traits in an Iranian Population, Journal of Research in Medical Sciences (2016)