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Optical Coherence Tomography (Oct) Measurements and Disability in Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis Publisher Pubmed



Mirmosayyeb O1 ; Yazdan Panah M2 ; Mokary Y2 ; Ghaffary EM2 ; Ghoshouni H2 ; Zivadinov R3, 4 ; Weinstockguttman B1 ; Jakimovski D1, 3
Authors
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Authors Affiliations
  1. 1. Department of Neurology, Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States
  2. 2. Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Buffalo, 14203, NY, United States
  4. 4. Center for Biomedical Imaging at the Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, United States

Source: Journal of the Neurological Sciences Published:2023


Abstract

Background: Studies have demonstrated that people with multiple sclerosis (pwMS) experience visual impairments and neurodegenerative retinal processes. The disability progression in pwMS may be associated with retinal changes assessed with optical coherence tomography (OCT). This meta-analysis aims at synthesizing the correlations between OCT measurements of disability in pwMS. Methods: We systematically searched four databases (PubMed/MEDLINE, Embase, Scopus, and Web of Science) from inception to November 2022, then conducted a meta-analysis using a random effects model to determine the pooled correlation coefficient(r) between OCT measurements and disability scales by R version 4.2.3 with the meta version 6.2–1 package. Results: From 3129 studies, 100 studies were included. Among 9051 pwMS, the female-to-male ratio was 3.15:1, with a mean age of 39.57 ± 6.07 years. The mean disease duration and Expanded Disability Status Scale (EDSS) were 8.5 ± 3.7 and 2.7 ± 1.1, respectively. Among the pooled subgroup analyses, macular ganglion cell inner plexiform layer (mGCIPL) in patients with relapsing-remitting (pwRRMS) and peripapillary retinal nerve fiber layer (pRNFL) in patients with progressive MS (pwPMS) had strong correlations with EDSS, r = −0.33 (95% CI: −0.45 to −0.20, I2 = 45%, z-score = −4.86, p < 0.001) and r = −0.20 (95% CI:-0.58 to 0.26, I2 = 76%, z-score = −0.85, p = 0.395), respectively. According to subgroup analysis on pwMS without optic neuritis (ON) history, the largest correlation was seen between EDSS and macular ganglion cell complex (mGCC): r = −0.39 (95% CI: −0.70 to 0.04, I2 = 79%, z-score = −1.79, p = 0.073). Conclusion: OCT measurements are correlated with disability in pwMS, and they can complement the comprehensive neurological visit as an additional paraclinical test. © 2023 Elsevier B.V.
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