The Effect of Synthetic Curcumin Analogues on Obesity, Diabetes and Cardiovascular Disease: A Literature Review Publisher Pubmed



Lavian S¹ ; Mardaneh P² ; Bagherniya M^{3, 4, 5} ; Emami SA⁶ ; Butler AE⁷ ; Sahebkar A^{8, 9, 10} Show Affiliations
Source: Current Medicinal Chemistry Published:2023

Abstract

Obesity, as an unfavorable consequence of our modern lifestyle, can promote the emergence of other disorders, like diabetes and cardiovascular disease, that negative-ly impact quality of life. Therefore, prevention and treatment of obesity and its related co-morbidities are critical. Lifestyle modification is the first and most important step but, in practical terms, presents a major challenge to many patients. So, the development of new strategies and therapies is critical for these patients. Although herbal bioactive compounds have recently gained attention for their ability to prevent and treat conditions related to obesity, no ideal pharmacological treatment has been found to treat obesity. Cur-cumin, one of the compounds extracted from turmeric, is a well-studied active herbal ex-tract; however, its poor bioavailability and solubility in water, instability against tempera-ture, light and pH fluctuations and rapid excretion limit its therapeutic application. Curcu-min modification can, however, provide novel analogues with better performance and fewer disadvantages in comparison to the original structure. In the past few years, the positive effects of synthetic analogues of curcumin for the treatment of obesity, diabetes and cardiovascular disorders have been reported. In this review, we evaluate the strengths and weaknesses of the reported artificial derivatives and assess their practicality as therapeutic agents. © 2023 Bentham Science Publishers.