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Polysaccharides Derived From Tragacanth As Biocompatible Polymers and Gels Publisher



Fattahi A1, 2, 3 ; Petrini P4 ; Munarin F4 ; Shokoohinia Y5 ; Golozar MA1 ; Varshosaz J3 ; Tanzi MC4
Authors

Source: Journal of Applied Polymer Science Published:2013


Abstract

Tragacanth gum (TG) is a natural gum whose biomedical applications are limited because of the low water solubility and the possibility to form only weak water-insoluble gels. An innovative method to produce water-soluble tragacanth (WST) is assessed in this work. WST structural characterization indicates a high-molecular weight polyuronic acid, which can undergo gelling by ionotropic complexation. Biological characterization shows no cytotoxicity on Hela, HepG2, and L929 cell lines. Furthermore, TG-based and WST-based gel beads prepared by ionic crosslinking with ferric and zinc ions are studied. Ferric WST gels exerted better cell adhesion with L929 cells than ferric alginate gels. These characteristics make WST a promising candidate for tissue engineering and drug delivery applications. © 2013 Wiley Periodicals, Inc.
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