Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review Publisher

Summary: Research shows citrus flavonoids reduce skin aging and inflammation, offering natural solutions for healthier skin. #SkinHealth #Nutrition

Sebghatollahi Z¹ ; Ghanadian M² ; Agarwal P³ ; Ghaheh HS⁴ ; Mahato N⁵ ; Yogesh R⁶ ; Hejazi SH¹

Source: ACS Food Science and Technology Published:2022

Abstract

Citrus fruits are one of the most popular sources of dietary flavonoids, such as hesperidin, hesperetin, naringin, naringenin, quercetin, rutin, diosmin, diosmetin, kaempferol, myricetin, nobiletin, tangeretin, and so on. Flavonoids are polyphenols and aromatic bioactive compounds occurring in plants as secondary metabolites. These participate in various biochemical processes in the human body and help in promoting health. Citrus flavonoids are well-known for their antioxidant and anti-inflammatory properties. They promote wound healing and antimelanoma in addition to free radical scavenging, apoptosis, modulation of lipid metabolism, improvement of insulin sensitivity, and endothelial dysfunction. Citrus flavonoids serve as efficient therapeutics for treating various skin-related issues, such as skin aging/photoaging, skin pigmentation, and maintenance of overall healthy skin. This review is an attempt to compile relevant information from recently published articles addressing the roles of Citrus flavonoids in health-promoting activities, particularly skin health. In addition, it also provides a discussion on the recent progress in developing efficient topical delivery techniques to solve the challenge of flavonoids' poor water solubility and limited permeability into the skin. The review aims to provide a better understanding of the current trends in research and development in Citrus flavonoid biochemistry and their usage in the production of plant-based medicinal and pharma-/nutraceuticals for topical applications. © 2022 American Chemical Society.

Related Docs

View other Related Docs

1. Neuroprotective Effects of Flavonoids, Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects (2023)

2. The Potential Anti-Cancer Effects of Quercetin on Blood, Prostate and Lung Cancers: An Update, Frontiers in Immunology (2023)

3. Protective Effect of Flavonoids Against Red Blood Cell Hemolysis by Free Radicals, Experimental and Clinical Cardiology (2005)

Experts (# of related papers)

View all Related Experts

Sedigheh Asgary (4)

Valiollah Hajhashemi (2)

Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review

Other Related Docs

4. The Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Controlled Trials, International Journal of Clinical Practice (2021)

5. Antioxidant Activity in Some in Vitro Oxidative Systems of the Essential Oils From the Fruit and the Leaves of Platycladus Orientalis, Journal of Essential Oil Research (2011)

6. Anti-Inflammatory and Analgesic Properties of the Leaf Extracts and Essential Oil of Lavandula Angustifolia Mill., Journal of Ethnopharmacology (2003)

7. Targeting Multiple Signaling Pathways in Cancer: The Rutin Therapeutic Approach, Cancers (2020)

8. Does Anthocyanins Consumption Affect Weight and Body Composition? a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Obesity Science and Practice (2023)

9. Discovery of Novel Rarα Agonists Using Pharmacophore-Based Virtual Screening, Molecular Docking, and Molecular Dynamics Simulation Studies, PLoS ONE (2023)

10. Therapeutic Potential of Quercetin on Human Breast Cancer in Different Dimensions, Inflammopharmacology (2020)

11. Antioxidant Effects of Citrus Aurantifolia (Christm) Juice and Peel Extract on Ldl Oxidation, Journal of Research in Medical Sciences (2011)

12. The Effect of Citrus Aurantifolia (Lemon) Peels on Cardiometabolic Risk Factors and Markers of Endothelial Function in Adolescents With Excess Weight: A Triple-Masked Randomized Controlled Trial, Medical Journal of the Islamic Republic of Iran (2016)

13. Antinociceptive and Anti-Inflammatory Activities of Bunium Persicum Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models, Pharmaceutical Biology (2011)

14. Antioxidant Activity of Methanolic Leaf Extract of Moringa Peregrina (Forssk.) Fiori, Research in Pharmaceutical Sciences (2012)

15. Celery and Spinach Flavonoid-Rich Extracts Enhance Phytoalexin Production in Powdery Mildew-Infected Cucumber Leaves, Plants (2025)

16. A Narrative Review on the Role of Hesperidin on Metabolic Parameters, Liver Enzymes, and Inflammatory Markers in Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)

17. Cytotoxic Effects of Essential Oils of Some Iranian Citrus Peels, Iranian Journal of Pharmaceutical Research (2005)

18. Antimicrobial Activity and Wound Healing Effect of a Novel Natural Ointment: An in Vitro and in Vivo Study, Journal of Wound Care (2023)

19. Role of Bdnf Signaling in the Neuroprotective and Memory-Enhancing Effects of Flavonoids in Alzheimer’S Disease, CNS and Neurological Disorders - Drug Targets (2024)

20. Evaluation of the Effects of Vaccinium Arctostaphylos L. Fruit Extract on Serum Lipids and Hs-Crp Levels and Oxidative Stress in Adult Patients With Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2014)

Style	Citing Format
MLA	Sebghatollahi Z, et al.. "Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review." ACS Food Science and Technology, vol. 2, no. 9, 2022, pp. 1417-1432.
APA	Sebghatollahi Z, Ghanadian M, Agarwal P, Ghaheh HS, Mahato N, Yogesh R, Hejazi SH (2022). Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review. ACS Food Science and Technology, 2(9), 1417-1432.
Chicago	Sebghatollahi Z, Ghanadian M, Agarwal P, Ghaheh HS, Mahato N, Yogesh R, Hejazi SH. "Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review." ACS Food Science and Technology 2, no. 9 (2022): 1417-1432.
Harvard	Sebghatollahi Z et al. (2022) 'Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review', ACS Food Science and Technology, 2(9), pp. 1417-1432.
Vancouver	Sebghatollahi Z, Ghanadian M, Agarwal P, Ghaheh HS, Mahato N, Yogesh R, et al.. Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review. ACS Food Science and Technology. 2022;2(9):1417-1432.
BibTex	@article{ author = {Sebghatollahi Z and Ghanadian M and Agarwal P and Ghaheh HS and Mahato N and Yogesh R and Hejazi SH}, title = {Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review}, journal = {ACS Food Science and Technology}, volume = {2}, number = {9}, pages = {1417-1432}, year = {2022} }
RIS	TY - JOUR AU - Sebghatollahi Z AU - Ghanadian M AU - Agarwal P AU - Ghaheh HS AU - Mahato N AU - Yogesh R AU - Hejazi SH TI - Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review JO - ACS Food Science and Technology VL - 2 IS - 9 SP - 1417 EP - 1432 PY - 2022 ER -

Science Communicator Platform

Authors

Abstract