Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Citrus Flavonoids: Biological Activities, Implementation in Skin Health, and Topical Applications: A Review Publisher



Sebghatollahi Z1 ; Ghanadian M2 ; Agarwal P3 ; Ghaheh HS4 ; Mahato N5 ; Yogesh R6 ; Hejazi SH1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  2. 2. Isfahan Pharmaceutical Sciences Research Center, Isfahan Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  3. 3. Division of Chemistry, School of Basic and Applied Sciences, Galgotias University, Yamuna Expressway, Greater Noida, 203201, India
  4. 4. Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  5. 5. School of Chemical Engineering, Yeungnam University, Gyeongsangbuk, Gyeongsan, 38541, South Korea
  6. 6. 22 A3 DS Tower 1, Sukhumvit Soi 33, Khlong Tan Nuea, Wattana, 10110, Bangkok, Thailand

Source: ACS Food Science and Technology Published:2022


Abstract

Citrus fruits are one of the most popular sources of dietary flavonoids, such as hesperidin, hesperetin, naringin, naringenin, quercetin, rutin, diosmin, diosmetin, kaempferol, myricetin, nobiletin, tangeretin, and so on. Flavonoids are polyphenols and aromatic bioactive compounds occurring in plants as secondary metabolites. These participate in various biochemical processes in the human body and help in promoting health. Citrus flavonoids are well-known for their antioxidant and anti-inflammatory properties. They promote wound healing and antimelanoma in addition to free radical scavenging, apoptosis, modulation of lipid metabolism, improvement of insulin sensitivity, and endothelial dysfunction. Citrus flavonoids serve as efficient therapeutics for treating various skin-related issues, such as skin aging/photoaging, skin pigmentation, and maintenance of overall healthy skin. This review is an attempt to compile relevant information from recently published articles addressing the roles of Citrus flavonoids in health-promoting activities, particularly skin health. In addition, it also provides a discussion on the recent progress in developing efficient topical delivery techniques to solve the challenge of flavonoids' poor water solubility and limited permeability into the skin. The review aims to provide a better understanding of the current trends in research and development in Citrus flavonoid biochemistry and their usage in the production of plant-based medicinal and pharma-/nutraceuticals for topical applications. © 2022 American Chemical Society.
Related Docs
View other Related Docs
1. Neuroprotective Effects of Flavonoids, Phytonutrients and Neurological Disorders: Therapeutic and Toxicological Aspects (2023)
2. The Potential Anti-Cancer Effects of Quercetin on Blood, Prostate and Lung Cancers: An Update, Frontiers in Immunology (2023)
3. Protective Effect of Flavonoids Against Red Blood Cell Hemolysis by Free Radicals, Experimental and Clinical Cardiology (2005)
4. The Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation: A Systematic Review and Meta-Analysis of Controlled Trials, International Journal of Clinical Practice (2021)
5. The Effect of Cucurbita Consumption on Non-Communicable Diseases, Cucurbita: Biology, Distribution and Habitat (2020)
6. Protective Potential of Naringenin and Its Nanoformulations in Redox Mechanisms of Injury and Disease, Heliyon (2023)
7. Recent Advances in Food Applications of Phenolic-Loaded Micro/Nanodelivery Systems, Critical Reviews in Food Science and Nutrition (2023)
8. Anti-Nociceptive and Anti-Inflammatory Effects of Ferulago Angulata, Immunopathologia Persa (2020)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (8)
Mustafa Ghanadian (7)
Other Related Docs
9. Mirnas: Emerging Agents for Therapeutic Effects of Polyphenols on Ovarian Cancer, Mini-Reviews in Medicinal Chemistry (2024)
10. Wound Healing by Topical Application of Antioxidant Iron Chelators: Kojic Acid and Deferiprone, International Wound Journal (2013)
11. A Comprehensive Insight Into the Molecular and Cellular Mechanisms of Action of Resveratrol on Complications of Sepsis a Systematic Review, Phytotherapy Research (2023)
12. The Effect of Quercetin Supplementation on Selected Markers of Inflammation and Oxidative Stress, Journal of Research in Medical Sciences (2012)
13. Spinach Flavonoid-Rich Extract: Unleashing Plant Defense Mechanisms Against Cucumber Powdery Mildew, Sustainable Chemistry and Pharmacy (2024)
14. Therapeutic Potential of Resveratrol in the Treatment of Glioma: Insights Into Its Regulatory Mechanisms, Mini-Reviews in Medicinal Chemistry (2021)
15. Exploring Curcumin's Healing Properties in the Treatment of Atopic Dermatitis, Food Bioscience (2024)
16. Exploring the Interaction Between Epidermal Growth Factor Receptor Tyrosine Kinase and Some of the Synthesized Inhibitors Using Combination of In-Silico and In-Vitro Cytotoxicity Methods, Research in Pharmaceutical Sciences (2018)
17. Effect of Polyphenols Against Complications of Covid-19: Current Evidence and Potential Efficacy, Pharmacological Reports (2024)
18. Neurodegenerative and Cognition Losses During Aging (Memory) and Nutraceuticals, Nutraceuticals for Aging and Anti-Aging: Basic Understanding and Clinical Evidence (2021)
19. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)
20. Nutraceuticals for Multiple Sclerosis, Bioactive Nutraceuticals for Brain Disorders (2021)
21. Impacts of Fresh Lime Juice and Peel on Atherosclerosis Progression in an Animal Model, ARYA Atherosclerosis (2013)
22. Defense Mechanisms Induced by Celery Seed Essential Oil Against Powdery Mildew Incited by Podosphaera Fusca in Cucumber, Journal of Fungi (2024)
23. Rosemary and Its Protective Potencies Against Covid-19 and Other Cytokine Storm Associated Infections: A Molecular Review, Mediterranean Journal of Nutrition and Metabolism (2021)
24. Flavonoids Target Different Molecules of Autophagic and Metastatic Pathways in Cancer Cells, Cancer Cell International (2023)
25. The Effects of Citrus Flavonoids Supplementation on Endothelial Function: A Systematic Review and Dose–Response Meta-Analysis of Randomized Clinical Trials, Phytotherapy Research (2024)
26. Fabrication and Evaluation of Hesperidin Loaded Polyacrylonitrile/Polyethylene Oxide Nanofibers for Wound Dressing Application, Journal of Biomaterials Science, Polymer Edition (2021)
27. Quercetin Modulates Signal Transductions and Targets Non-Coding Rnas Against Cancer Development, Cellular Signalling (2023)
28. Evaluating Anti-Inflammatory Effect of Hydroalcoholic Extracts of Citrus Medica L. Pulp and Peel on Rat Model of Acute Colitis, Research Journal of Pharmacognosy (2023)
29. Evaluation of the Flavonol-Rich Fraction of Rosa Damascena in an Animal Model of Liver Fibrosis by Targeting the Expression of Fibrotic Cytokines, Antioxidant/Oxidant Ratio and Collagen Cross-Linking, Life Sciences (2023)
30. Silymarin Impacts on Immune System As an Immunomodulator: One Key for Many Locks, International Immunopharmacology (2017)
31. Therapeutic Potential of Berries in Age-Related Neurological Disorders, Frontiers in Pharmacology (2024)
32. Anti-Oxidant Effect of Flavonoids on the Susceptibility of Ldl Oxidation, Molecular and Cellular Biochemistry (2003)
33. Cardiovascular Protective Effects of Cinnamic Acid As a Natural Phenolic Acid: A Review, Archives of Physiology and Biochemistry (2025)
34. Methoxylated Flavones From Salvia Mirzayanii Rech. F. and Esfand With Immunosuppressive Properties, Iranian Journal of Pharmaceutical Research (2015)
35. Isolation and Characterization of Methylated Flavones From Artemisia Kermanensis, Advanced Biomedical Research (2021)
36. Effect of Grape Polyphenols on Selected Inflammatory Mediators: A Systematic Review and Meta-Analysis Randomized Clinical Trials, EXCLI Journal (2020)
37. Effects of Citrus Sinensis Juice on Blood Pressure, ARYA Atherosclerosis (2013)
38. Flavonol Glycosides From Euphorbia Microsciadia Bioss. With Their Immunomodulatory Activities, Iranian Journal of Pharmaceutical Research (2012)
39. A Review of Plant‑Based Compounds and Medicinal Plants Effective on Atherosclerosis, Journal of Research in Medical Sciences (2017)
40. Effect of Kelussia Odoratissima Mozaffarian on Lipid and Glucose Profile, Shiraz E Medical Journal (2015)
41. Dietary Polyphenols for Atherosclerosis: A Comprehensive Review and Future Perspectives, Critical Reviews in Food Science and Nutrition (2019)
42. Effect of Genistein on Apoptosis and Proliferation of Hepatocellular Carcinoma Hepa1‑6 Cell Line, International Journal of Preventive Medicine (2018)
43. Quercetin With the Potential Effect on Allergic Diseases, Allergy, Asthma and Clinical Immunology (2020)
44. Evaluation of the Effects of Vaccinium Arctostaphylos L. Fruit Extract on Serum Lipids and Hs-Crp Levels and Oxidative Stress in Adult Patients With Hyperlipidemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Evidence-based Complementary and Alternative Medicine (2014)
45. Role of Bdnf Signaling in the Neuroprotective and Memory-Enhancing Effects of Flavonoids in Alzheimer’S Disease, CNS and Neurological Disorders - Drug Targets (2024)
46. Antimicrobial Activity and Wound Healing Effect of a Novel Natural Ointment: An in Vitro and in Vivo Study, Journal of Wound Care (2023)
47. Cytotoxic Effects of Essential Oils of Some Iranian Citrus Peels, Iranian Journal of Pharmaceutical Research (2005)
48. A Narrative Review on the Role of Hesperidin on Metabolic Parameters, Liver Enzymes, and Inflammatory Markers in Nonalcoholic Fatty Liver Disease, Food Science and Nutrition (2023)
49. Antioxidant Activity of Methanolic Leaf Extract of Moringa Peregrina (Forssk.) Fiori, Research in Pharmaceutical Sciences (2012)
50. Antinociceptive and Anti-Inflammatory Activities of Bunium Persicum Essential Oil, Hydroalcoholic and Polyphenolic Extracts in Animal Models, Pharmaceutical Biology (2011)