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Investigation on Bioactivity and Cytotoxicity of Mesoporous Nano-Composite Mcm-48/Hydroxyapatite for Ibuprofen Drug Delivery Publisher



Aghaei H1 ; Nourbakhsh AA2 ; Karbasi S3 ; Javadkalbasi R4 ; Rafienia M5 ; Nourbakhsh N6 ; Bonakdar S7 ; Mackenzie KJD8
Authors
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Authors Affiliations
  1. 1. Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Isfahan, P.O. Box 517, Iran
  2. 2. Department of Materials Engineering, Shahreza Branch, Islamic Azad University, 86137 Isfahan, Iran
  3. 3. Biomaterials Nanotechnology and Tissue Engineering Group, Advanced Medical Technology Department, Isfahan, Iran
  4. 4. Department of Chemistry, Shahreza Branch, Islamic Azad University, 86137 Isfahan, Iran
  5. 5. Biosensor Research Center, Isfahan University of Medical Sciences, 817473461 Isfahan, Iran
  6. 6. Department of Pediatric Dentistry, Isfahan University of Medical Sciences, Torabinejad Dental Research Center, Iran
  7. 7. National Cell Bank of Iran, Pasteur Institute of Iran, 1316943551 Tehran, Iran
  8. 8. MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, 6140 Wellington, New Zealand

Source: Ceramics International Published:2014


Abstract

A novel in situ synthesis is presented of a hydroxyapatite composite with the mesoporous silicate MCM-48 with potential applications as a drug delivery agent. The structure and properties of this nanocomposite, investigated by a number of techniques including XRD, SEM and TEM, show the intergrowth of the hydroxyapatite particles with the silica structure. The bioactivity of the new material was determined by measuring the decrease in the calcium ion concentration of simulated body fluid (SBF) after soaking the nanocomposite, while the uptake of ibuprofen on MCM-48 and MCM-48/HAp composite from ethanol was monitored by UV spectroscopy at 222 nm which was also used to monitor the release of ibuprofen into SBF, MTT assay was used to assess effect of the sample on MG68 cell live proliferation. The results confirm the successful synthesis of a MCM-48/hydroxyapatite nanocomposite and its potential biomedical applications as a bioactive ceramic and as a drug delivery agent with a higher rate of ibuprofen release compared to MCM-48. © 2013 Elsevier Ltd and Techna Group S.r.l.All rights reserved.
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