Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Utility of Hypertriglyceridemic Waist Phenotype for Predicting Incident Type 2 Diabetes: The Isfahan Diabetes Prevention Study Publisher Pubmed



Janghorbani M1 ; Amini M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Diabetes Investigation Published:2016


Abstract

Aim/Introduction: We evaluated the association between hypertriglyceridemic waist (HTW) phenotype and the risks of type 2 diabetes in an Iranian high-risk population. Materials and Methods: We analyzed 7-year follow-up data (n = 1,865) in non-diabetic first-degree relatives of consecutive patients with type 2 diabetes aged 30–70 years. The primary outcome was the diagnosis of type 2 diabetes based on repeated oral glucose tolerance tests. We used multiple logistic regressions to estimate the odds ratio (OR) for incident type 2 diabetes across four groups according to baseline fasting serum triglycerides (TG) level and waist circumference (WC): normal WC and normal TG, normal WC and high TG, enlarged WC and normal TG, and HTW (enlarged WC high TG). Results: The HTW phenotype at baseline was associated with the incidence of type 2 diabetes. Those with HTW were 2.4-fold (OR 2.36, 95% confidence interval 1.61–3.44), those with normal WC high TG were 1.9-fold (OR 1.87, 95% confidence interval 1.29–2.70) and those with enlarged WC but normal TG were 2.8-fold (OR 2.84, 95% confidence interval 1.96–4.13) more likely to develop type 2 diabetes than those with normal WC and normal TG. Conclusions: These data provide further evidence that the HTW phenotype is a robust predictor of type 2 diabetes in high-risk individuals in Iran, and the predictive power is not higher than that of simple enlarged WC and normal TG, emphasizing the importance of enlarged WC to the development of type 2 diabetes. © 2016 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
Related Docs
View other Related Docs
1. The Visceral Adiposity Index in Comparison With Easily Measurable Anthropometric Markers Did Not Improve Prediction of Diabetes, Canadian Journal of Diabetes (2016)
2. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
3. Low Levels of High-Density Lipoprotein Cholesterol Do Not Predict the Incidence of Type 2 Diabetes in an Iranian High-Risk Population: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2016)
4. Risk of Diabetes in Combined Metabolic Abnormalities and Body Mass Index Categories, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2016)
5. Utility of the Visceral Adiposity Index and Hypertriglyceridemic Waist Phenotype for Predicting Incident Hypertension, Endocrinology and Metabolism (2017)
6. Comparison of Different Obesity Indices for Predicting Incident Hypertension, High Blood Pressure and Cardiovascular Prevention (2017)
7. Utility of Serum Lipid Ratios for Predicting Incident Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes/Metabolism Research and Reviews (2016)
8. Hypertriglyceridemic Waist Phenotype, Markers of Systemic Inflammation and Endothelial Dysfunction Among Women, Iranian Journal of Diabetes and Lipid Disorders (2007)
Experts (# of related papers)
View all Related Experts
Nizal Sarrafzadegan (63)
Roya Kelishadi (60)
Other Related Docs
9. Associations of Hip Circumference and Height With Incidence of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Acta Diabetologica (2012)
10. Anthropometric Indices Predicting Incident Type 2 Diabetes in an Iranian Population: The Isfahan Cohort Study, Diabetes and Metabolism (2013)
11. Normal Fasting Plasma Glucose and Risk of Prediabetes and Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2011)
12. Glycated Hemoglobin As a Predictor for Metabolic Syndrome in an Iranian Population With Normal Glucose Tolerance, Metabolic Syndrome and Related Disorders (2012)
13. Area Under the Curve During Ogtt in First-Degree Relatives of Diabetic Patients As an Efficient Indicator of Future Risk of Type 2 Diabetes and Prediabetes, Clinical Endocrinology (2017)
14. Evaluation of the Finnish Diabetes Risk Score (Findrisc) As a Screening Tool for the Metabolic Syndrome, The review of diabetic studies : RDS (2013)
15. Finnish Diabetes Risk Score to Predict Type 2 Diabetes in the Isfahan Diabetes Prevention Study, Diabetes Research and Clinical Practice (2013)
16. Determinants of Incident Metabolic Syndrome in a Middle Eastern Population: Isfahan Cohort Study, Metabolic Syndrome and Related Disorders (2017)
17. Comparison of Fasting Glucose With Post-Load Glucose Values and Glycated Hemoglobin for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2009)
18. Association of Triglyceride Glucose Index With Cardiovascular Events: Insights From the Isfahan Cohort Study (Ics), European Journal of Medical Research (2024)
19. Weight Status of the First-Degree Relatives of Patients With Type 2 Diabetes Based on the Glucose Tolerance Test, Journal of Research in Medical Sciences (2012)
20. Prevalence and Risk Factors of Diabetes Mellitus in the Isfahan City Population (Aged 40 or Over) in 1993, Diabetes Research and Clinical Practice (1997)
21. Should the First Degree Relatives of Type 2 Diabetic Patients With Isolated Impaired Fasting Glucose Be Considered for a Diabetes Primary Prevention Program?, Journal of Research in Medical Sciences (2010)
22. Diabetes and Impaired Glucose Regulation in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran: Prevalence and Risk Factors, Review of Diabetic Studies (2007)
23. Prevalence and Risk Factors of Diabetes, Pre-Diabetes and Metabolic Syndrome in First-Degree Relatives of Patients With Type Ii Diabetes, Journal of Kerman University of Medical Sciences (2013)
24. People With Impaired Glucose Tolerance and Impaired Fasting Glucose Are Similarly Susceptible to Cardiovascular Disease: A Study in First-Degree Relatives of Type 2 Diabetic Patients, Annals of Nutrition and Metabolism (2010)
25. Comparison of Metabolic Syndrome With Glucose Measurement for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2009)
26. Metabolic Syndrome in Type 2 Diabetes Mellitus in Isfahan, Iran: Prevalence and Risk Factors, Metabolic Syndrome and Related Disorders (2007)
27. How Is Healthy Eating Index-2015 Related to Risk Factors for Cardiovascular Disease in Patients With Type 2 Diabetes, Frontiers in Nutrition (2023)
28. Association of Hypertriglyceridemic-Waist Phenotype With Liver Enzymes and Cardiometabolic Risk Factors in Adolescents: The Caspian-Iii Study; [Associacao Do Fenotipo De Cintura Hipertrigliceridemica Com Enzimas Hepaticas E Fatores De Risco Cardiometabolico Em Adolescentes: O Estudo Caspian-Iii], Jornal de Pediatria (2016)
29. Comparison of Glycated Hemoglobin With Fasting Plasma Glucose in Definition of Glycemic Component of the Metabolic Syndrome in an Iranian Population, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2012)
30. Effects of Gender and Height on the Oral Glucose Tolerance Test: The Isfahan Diabetes Prevention Study, Review of Diabetic Studies (2008)
31. Prevalence of Uncontrolled Diabetes and Its Predictors in Patients With Type 2 Diabetes Covered by Comprehensive Health Care Centers of Isfahan, Iranian Journal of Endocrinology and Metabolism (2022)
32. Dietary Insulin Index and Insulin Load in Relation to Hypertriglyceridemic Waist Phenotype and Low Brain Derived Neurotrophic Factor in Adults, Frontiers in Nutrition (2022)
33. Diabetes and Associated Cardiovascular Risk Factors in Iran: The Isfahan Healthy Heart Programme, Annals of the Academy of Medicine Singapore (2007)
34. Novel Anthropometric Indices for Predicting Type 2 Diabetes Mellitus, BMC Public Health (2024)
35. Association Between Type 2 Diabetes and Different Types of Dietary Fats: A Case-Control Study, Clinical Nutrition ESPEN (2023)
36. Incidence of Type 2 Diabetes by Hba1c and Ogtt: The Isfahan Diabetes Prevention Study, Acta Diabetologica (2012)
37. The Association of Hypertriglyceridemic Waist Phenotype With Type 2 Diabetes Mellitus Among Individuals With First Relative History of Diabetes, Journal of Research in Medical Sciences (2011)
38. Glucose and the Risk of Hypertension in First-Degree Relatives of Patients With Type 2 Diabetes, Hypertension Research (2015)
39. Comparison of Body Mass Index With Abdominal Obesity Indicators and Waist-To-Stature Ratio for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Obesity Research and Clinical Practice (2010)
40. Risk of Diabetes According to the Metabolic Health Status and Degree of Obesity, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2017)
41. Determinants of Incident Prediabetes and Type 2 Diabetes in a 7-Year Cohort in a Developing Country: The Isfahan Cohort Study, Journal of Diabetes (2015)
42. Association of the Triglyceride Glucose Index With All-Cause and Cardiovascular Mortality in a General Population of Iranian Adults, Cardiovascular Diabetology (2024)
43. Progression to Impaired Glucose Metabolism in First-Degree Relatives of Patients With Type 2 Diabetes in Isfahan, Iran, Diabetes/Metabolism Research and Reviews (2009)
44. Comparison of Systolic and Diastolic Blood Pressure With Pulse Pressure and Mean Arterial Pressure for Prediction of Type 2 Diabetes: The Isfahan Diabetes Prevention Study, Endokrynologia Polska (2011)
45. The Characteristics of Pre-Diabetic Patients Associated With Body Composition and Cardiovascular Disease Risk Factors in the Iranian Population, Journal of Research in Medical Sciences (2016)
46. Dietary Glycemic Index and Insulin Index in Association With Incident Type 2 Diabetes Mellitus in Adults, British Journal of Nutrition (2025)
47. The Prevalence of Impaired Fasting Glucose and Type 2 Diabetes in a Population-Based Sample of Overweight/Obese Children in the Middle East, Pediatric Diabetes (2010)
48. The Association Between Hypertriglyceridemic Waist Phenotype, Menopause, and Cardiovascular Risk Factors, Archives of Iranian Medicine (2013)
49. Patterns of Changes in Fasting Plasma Glucose, Hemoglobin A1c and the Area Under the Curve During Oral Glucose Tolerance Tests in Prediabetic Subjects: Results From a 16-Year Prospective Cohort Study Among First-Degree Relatives of Type 2 Diabetic Patients, Acta Diabetologica (2021)
50. Association of Lipid Profile With Type 2 Diabetes in First-Degree Relatives: A 14-Year Follow-Up Study in Iran, Diabetes, Metabolic Syndrome and Obesity (2020)