Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effects of Oat and Wheat Bread Consumption on Lipid Profile, Blood Sugar, and Endothelial Function in Hypercholesterolemic Patients: A Randomized Controlled Clinical Trial



Momenizadeh A1 ; Heidari R2 ; Sadeghi M3 ; Tabesh F1 ; Ekramzadeh M1 ; Haghighatian Z4 ; Golshahi J3 ; Baseri M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Hypertension Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: ARYA Atherosclerosis Published:2014

Abstract

BACKGROUND: Increased lipid profile after each meal can disturb the endothelial function. The present study assessed the effects of bread supplemented with oat bran on serum lipids and endothelial dysfunction in patients with hypercholesterolemia.; METHODS: This clinical trial was conducted on 60 isolated hypercholesterolemic patients. The subjects were randomly allocated to either intervention (consuming at least five daily servings of oat bread with 6 g beta-glucan) or control (receiving at least five servings of wheat bread). Anthropometric indicators, fasting blood sugar and lipid profiles ere measured at baseline and after 6 weeks (in the end of the intervention). Endothelial function was assessed using flowmediated dilation (FMD). Within the group and between group differences were investigated using paired t-test and Student’s t-test, respectively.; RESULTS: Oat bread consumption could significantly reduce total cholesterol (P = 0.029). A significant increase in baseline and after ischemia brachial artery diameters at the end of the study was seen. However, it did not have a significant effect on FMD (P = 0.825). In the control group, none of the measured indices had changed significantly at the end of the study. Finally, only the mean change of brachial artery diameter after ischemia and baseline brachial artery diameter were significantly higher in the intervention group than in the control group (P = 0.036 and P = 0.012 respectively).; CONCLUSION: Oat bread with beta-glucan could successfully reduce cholesterol levels. Furthermore, in this study oat bread did not reduce FMD more than wheat bread. Since hypercholesterolemia is a proven risk factor for endothelial dysfunction, hypercholesterolemic patients can hence be advised to eat oat bread. © 2014, Isfahan University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. The Effects of Beta-Glucan Rich Oat Bread on Serum Nitric Oxide and Vascular Endothelial Function in Patients With Hypercholesterolemia, BioMed Research International (2014)
2. Effects of Breads Containing Flaxseeds on Serum Levels of Apelin and Lipids in Hyperlipidemic Patients, Iranian Journal of Nutrition Sciences and Food Technology (2021)
3. Effect of Oat (Avena Sativa L.) Consumption on Lipid Profile With Focus on Triglycerides and High-Density Lipoprotein Cholesterol (Hdl-C): An Updated Systematic Review, Current Problems in Cardiology (2023)
4. Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects, Phytotherapy Research (2014)
5. Antihyperlipidemic Effects of Sesamum Indicum L. in Rabbits Fed a High-Fat Diet, The Scientific World Journal (2013)
6. Suppressive Impact of Anethum Graveolens Consumption on Biochemical Risk Factors of Atherosclerosis in Hypercholesterolemic Rabbits, International Journal of Preventive Medicine (2013)
7. Effects of Yogurt and Yogurt Plus Shallot Consumption on Lipid Profiles in Type 2 Diabetic Women, International Journal of Preventive Medicine (2017)
8. Enzymatic Antioxidant System and Endothelial Function in Patients With Metabolic Syndrome, ARYA Atherosclerosis (2020)
Experts (# of related papers)
View all Related Experts
Sedigheh Asgary (36)
Nizal Sarrafzadegan (32)
Other Related Docs
9. Effect of Flaxseed on Blood Lipid Level in Hyperlipidemic Patients, Reviews on Recent Clinical Trials (2015)
10. Von Willebrand Factor, C-Reactive Protein, Nitric Oxide, and Vascular Endothelial Growth Factor in a Dietary Reversal Model of Hypercholesterolemia in Rabbit., Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia (2008)
11. Anethum Graveolens and Hyperlipidemia: A Randomized Clinical Trial, Journal of Research in Medical Sciences (2014)
12. The Effect of Aspirin on Serum Vascular Endothelial Growth Factor and Nitric Oxide Concentration in High-Cholesterol Fed Rabbits, ARYA Atherosclerosis (2007)
13. The Effects of Wheat Germ Supplementation on Metabolic Profile in Patients With Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Placebo-Controlled Trial, Phytotherapy Research (2020)
14. Rice Bran Oil Decreases Total and Ldl Cholesterol in Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials, Hormone and Metabolic Research (2016)
15. Lipid Lowering by Hydroalcoholic Extracts of Amaranthus Caudatus L. Induces Regression of Rabbits Atherosclerotic Lesions, Lipids in Health and Disease (2011)
16. Effect of Low-Energy-Dense Diet Rich in Multiple Functional Foods on Weight-Loss Maintenance, Inflammation, and Cardiovascular Risk Factors: A Randomized Controlled Trial, Journal of the American College of Nutrition (2018)
17. Effect of Fenugreek Seeds on Blood Glucose and Lipid Profiles in Type 2 Diabetic Patients, International Journal for Vitamin and Nutrition Research (2009)
18. Association Between Plant and Animal Proteins Intake With Lipid Profile and Anthropometric Indices: A Cross-Sectional Study, Nutrition and Health (2024)
19. Is Any Association Between Alternate Healthy Eating Index (Ahei) With Lipid Profile and Liver Enzymes? a Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2021)
20. The Relationship Between Fermented and Nonfermented Dairy Products Consumption and Hypertension Among Premature Coronary Artery Disease Patients: Iran Premature Coronary Artery Disease Study, Food Science and Nutrition (2024)
21. Changes in Serum Lipid Profile of Obese or Overweight Children and Adolescents Following a Lifestyle Modification Course, ARYA Atherosclerosis (2012)
22. Does Alpha-Lipoic Acid Affect Lipid Profile? a Meta-Analysis and Systematic Review on Randomized Controlled Trials, European Journal of Pharmacology (2019)
23. Longitudinal Association of Dietary Carbohydrate and the Risk Cardiovascular Disease: A Dose-Response Meta-Analysis, Critical Reviews in Food Science and Nutrition (2022)
24. Evaluation of the Effects of Roselle (Hibiscus Sabdariffa L.) on Oxidative Stress and Serum Levels of Lipids, Insulin and Hs-Crp in Adult Patients With Metabolic Syndrome: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Complementary and Integrative Medicine (2016)
25. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
26. Dash Diet, Insulin Resistance, and Serum Hs-Crp in Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial, Hormone and Metabolic Research (2015)
27. Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins, Journal of Isfahan Medical School (2011)
28. Association of Whole and Refined Grains Food Consumption With Coronary Artery Disease in a Multi-Center, Case-Control Study of Iranian Adults: Iran Premature Coronary Artery Disease (Ipad), Nutrition, Metabolism and Cardiovascular Diseases (2025)
29. Adherence to Alternative Healthy Eating Index (Ahei-2010) Is Not Associated With Risk of Stroke in Iranian Adults: A Case-Control Study, International Journal for Vitamin and Nutrition Research (2021)
30. Effects of Daily Consumption of Cashews on Oxidative Stress and Atherogenic Indices in Patients With Type 2 Diabetes: A Randomized, Controlled-Feeding Trial, International Journal of Endocrinology and Metabolism (2019)
31. Whole Grain Intake Favorably Affects Blood Glucose and Serum Triacylglycerols in Overweight and Obese Children: A Randomized Controlled Crossover Clinical Trial, Nutrition (2021)
32. Intake of Legumes and the Risk of Cardiovascular Disease: Frailty Modeling of a Prospective Cohort Study in the Iranian Middle-Aged and Older Population, European Journal of Clinical Nutrition (2016)
33. Is Subcutaneous Fat Tissue Associated With Coronary Artery Disease?, Iranian Journal of Endocrinology and Metabolism (2012)
34. Effect of Potato Consumption As a High Glycemic Index Food on Pre-Diabetes Adult Patients, Pakistan Journal of Medical Sciences (2013)
35. The Effects of L-Arginine on Serum Lipid Levels in Hypercholesterolemic Rabbits and Its in Vitro Antioxidant Activity, Journal of Isfahan Medical School (2007)
36. Comparison Common Equations for Ldl-C Calculation With Direct Assay and Developing a Novel Formula in Iranian Children and Adolescents: The Caspian V Study, Lipids in Health and Disease (2020)
37. Clinical Effects of Rhus Coriaria Fruits on Dyslipidemia308 in Adolescents: A Triple-Blinded Randomized Placebo-Controlled Trial, Medical archives (Sarajevo, Bosnia and Herzegovina) (2014)
38. The Effects of Concurrent Hydroalcoholic Extract of Amaranthus Caudatus L. and Hypericum Perforatum L. of Fatty Streak Formation in Hypercholesterolemic Animals, African Journal of Pharmacy and Pharmacology (2011)
39. The Association Between Glycemic Index, Glycemic Load and Total Carbohydrate Intake and Risk of Premature Coronary Artery Disease: Iran Premature Coronary Artery Disease Study (Ipad) - a Case-Control Study, Nutrition, Metabolism and Cardiovascular Diseases (2024)
40. Inverse Association of Legume Consumption and Dyslipidemia: Isfahan Healthy Heart Program, Journal of Clinical Lipidology (2014)
41. Potato Consumption and Cardiovascular Disease Risk Factors Among Iranian Population, International Journal of Food Sciences and Nutrition (2012)
42. Effect of Sesame Supplementation on Body Composition and Lipid Profile in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Nutrition, Metabolism and Cardiovascular Diseases (2024)
43. Effects of Dietary Whole Grain, Fruit, and Vegetables on Weight and Inflammatory Biomarkers in Overweight and Obese Women, Eating and Weight Disorders (2020)
44. The Association Between Carbohydrate Intake and Metabolic Syndrome, Journal of Isfahan Medical School (2011)
45. Effects of Cigarette Smoking on Postprandial Triglyceride in Healthy Smokers, Iranian Journal of Diabetes and Lipid Disorders (2010)
46. The Effect of Brassica Vegetables on Blood Glucose Levels and Lipid Profiles in Adults. a Systematic Review and Meta-Analysis, Phytotherapy Research (2022)
47. Evaluation of Relationship Between Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients Blood Peroxidases Activity and Visfatin Levels in Metabolic Syndrome Patients, ARYA Atherosclerosis (2014)
48. Nutraceuticals in Hyperlipidemic Children: A Systematic Review and Meta-Analysis, International Journal of Pediatrics (2016)
49. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits, ARYA Atherosclerosis (2023)
50. Effects of Dietary Red Clover on Blood Factors and Cardiovascular Fatty Streak Formation in Hypercholesterolemic Rabbits, Phytotherapy Research (2007)