Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma

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Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma Publisher Pubmed

Suwan Y¹ ; Chansangpetch S^{2, 3} ; Fard MA⁴ ; Pooprasert P¹ ; Chalardsakul K² ; Threetong T^{1, 5} ; Tipparut S¹ ; Saaensupho T¹ ; Tantraworasin A^{6, 7} ; Hojati S⁸ ; Kafieh R⁹ ; Danesh H¹⁰ ; Petpiroon P¹ ; Supakontanasan W¹

Show Affiliations

1. Department of Ophthalmology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
2. Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
3. Center of Excellence in Glaucoma, Chulalongkorn University, Bangkok, Thailand
4. Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Ophthalmology, Burapha University Hospital, Chonburi, Thailand
6. Surgery and Clinical Epidemiology and Clinical Statistic Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
7. Clinical Surgical Research Center, Chiang Mai University, Chiang Mai, Thailand
8. Medical Image and Signal Processing Research Center, School of Advanced Technologies in Medicine, University of Medical Sciences, Isfahan, Iran
9. Engineering Department, Durham University, Durham, United Kingdom
10. Department of Electrical and Biomedical Engineering, Faculty of Engineering and Technology, Shahid Ashrafi Esfahani University, Isfahan, Iran

Source: PLoS ONE Published:2025

Abstract

Background/Aims To compare parapapillary choroidal microvascular (PPCMv) densities between myopic eyes with and without glaucoma. Methods In this retrospective study, OCTA images (4.5 × 4.5 mm) were obtained using a commercial spectral-domain OCTA system. PPCMv density was calculated in inner and outer annuli using customized software. Marginal model of generalized estimating equations was established to adjust for confounding factors and intraclass correlations. Results This study included 35 myopic eyes with glaucoma (MG), 96 non-myopic eyes with glaucoma (NMG) matched for visual field mean deviation, 37 myopic eyes without glaucoma (MNG), and 73 control eyes from three tertiary centers. The participant ages were (mean [standard deviation, SD]) 57.43 [11.49], 60.40 [10.07], 52.84 [9.35], and 54.74 [12.07] years. Inner and outer annular PPCMv densities (mean [SD]) decreased in the following order: control (0.15 [0.04] and 0.12 [0.04]), MNG (0.14 [0.08] and 0.12 [0.08]), NMG (0.09 [0.05] and 0.07 [0.04]), and MG (0.09 [0.04] and 0.07 [0.03]). The mean differences in PPCMv density between glaucoma groups (NMG and MG) and the control group (mean difference [95% confidence interval]) were −0.06 (−0.08 to −0.04, P<0.001 for inner whole annular PPCMv density in NMG vs control) and −0.07 (−0.10 to −0.04, P<0.001 for inner whole annular PPCMv density in MG vs control), consistent across all regions of interest (ROIs). No significant interaction was observed between glaucoma and myopia after adjustment for potential confounders (P>0.112). Conclusions Parapapillary choroidal microvascular density attenuation tends to be greater in eyes with glaucoma than in eyes with myopia. © 2025 Suwan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Style	Citing Format
MLA	Suwan Y, et al.. "Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma." PLoS ONE, vol. 20, no. 2 February, 2025, pp. -.
APA	Suwan Y, Chansangpetch S, Fard MA, Pooprasert P, Chalardsakul K, Threetong T, Tipparut S, Saaensupho T, Tantraworasin A, Hojati S, Kafieh R, Danesh H, Petpiroon P, Supakontanasan W (2025). Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma. PLoS ONE, 20(2 February), -.
Chicago	Suwan Y, Chansangpetch S, Fard MA, Pooprasert P, Chalardsakul K, Threetong T, Tipparut S, et al.. "Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma." PLoS ONE 20, no. 2 February (2025): -.
Harvard	Suwan Y et al. (2025) 'Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma', PLoS ONE, 20(2 February), pp. -.
Vancouver	Suwan Y, Chansangpetch S, Fard MA, Pooprasert P, Chalardsakul K, Threetong T, et al.. Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma. PLoS ONE. 2025;20(2 February):-.
BibTex	@article{ author = {Suwan Y and Chansangpetch S and Fard MA and Pooprasert P and Chalardsakul K and Threetong T and Tipparut S and Saaensupho T and Tantraworasin A and Hojati S and Kafieh R and Danesh H and Petpiroon P and Supakontanasan W}, title = {Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma}, journal = {PLoS ONE}, volume = {20}, number = {2 February}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Suwan Y AU - Chansangpetch S AU - Fard MA AU - Pooprasert P AU - Chalardsakul K AU - Threetong T AU - Tipparut S AU - Saaensupho T AU - Tantraworasin A AU - Hojati S AU - Kafieh R AU - Danesh H AU - Petpiroon P AU - Supakontanasan W TI - Association of Myopia and Parapapillary Choroidal Microvascular Density in Primary Open-Angle Glaucoma JO - PLoS ONE VL - 20 IS - 2 February SP - EP - PY - 2025 ER -

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