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Plant Molecular Farming: Production of Metallic Nanoparticles and Therapeutic Proteins Using Green Factories Publisher



Mohammadinejad R1 ; Shavandi A2 ; Raie DS3 ; Sangeetha J4 ; Soleimani M5 ; Shokrian Hajibehzad S6 ; Thangadurai D7 ; Hospet R7 ; Popoola JO8 ; Arzani A9 ; Gomezlim MA10 ; Iravani S11 ; Varma RS12
Authors
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Authors Affiliations
  1. 1. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. BioMatter Unit-Biomass Transformation Lab (BTL), Ecole Interfacultaire de Bioingenieurs (EIB), Ecole Polytechnique de Bruxelles, Universite Libre de Bruxelles, Avenue F.D. Roosevelt 50-CP 165/61, Brussels, 1050, Belgium
  3. 3. Egyptian Petroleum Research Institute (EPRI), Nasr City Cairo, Egypt
  4. 4. Department of Environmental Science, Central University of Kerala, Kasaragod Kerala, 671316, India
  5. 5. Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Molecular Plant Physiology, Department of Biology, Faculty of Sciences, Utrecht University, Padualaan 8, Utrecht, 3584 CH, Netherlands
  7. 7. Department of Botany, Karnatak University, Dharwad Karnataka, 580003, India
  8. 8. Department of Biological Sciences, Biotechnology Centre, Covenant University, P.M.B. 1023, Canaanland, Ota Ogun State, Nigeria
  9. 9. Department of Agronomy and Plant Breeding, College of Agriculture, Isfahan University of Technology, Isfahan, 8415683111, Iran
  10. 10. Centro de Investigacion y de Estudios Avanzados Del IPN, Unidad Irapuato, Km. 9.6 Libramiento Norte Carretera Irapuato-Leon, Irapuato Guanajuato, 36824, Mexico
  11. 11. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  12. 12. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, 783 71, Czech Republic

Source: Green Chemistry Published:2019


Abstract

Plants have had numerous biological, clinical, pharmaceutical and medicinal purposes for many years; however, their use as a general platform for preparation of desired pharmaceutical and biomedical compounds is relatively current. Secondary metabolites with remarkable and diverse biological functions are produced by medicinal plants. Significant advancements in nanosciences have enabled their various applications in the development of a new generation of drug molecules. Due to the application of toxic solvents and high energy consumption of conventional physical and chemical approaches, greener and eco-friendly methods are essential and vital. Plants can provide an outstanding alternative for the production of phytomaterials and biomaterials, and this review highlights the exogenous and endogenous syntheses of nanoparticles using living plants. Additionally, the plant nano-molecular farming of proteins including collagen, gelatin, elastin, recombinant anti-cancer monoclonal antibodies and recombinant anti-cancer vaccines is discussed. © 2019 The Royal Society of Chemistry.
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