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Human Anti-Toxoplasma Antibodies Attach Strongly to Breast Cancer Cells Publisher



Hosseini F1 ; Farahbakhsh Z1 ; Balouti A1 ; Kalantari R1 ; Pourshahbazi G1 ; Mobarakeh SM1 ; Yousefi M2 ; Darani HY1
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: International Journal of Cancer Management Published:2023


Abstract

Background: Toxoplasma gondii (T. gondii) is the most common intracellular parasite in the human population. The anti-cancer effect of these parasites has been shown, which may be due to the presence of common antigens between the parasite and cancer cells. Objectives: In this work, the reaction of Toxoplasma-positive human sera and Toxoplasma-negative human sera with cell surfaces of 4T1 and MCF7 cell lines have been investigated. Methods: 4T1 and MCF7 cells were harvested from cell cultures and treated with either human Toxoplasma Positive or negative sera. The reaction of the sera was then detected using the flow cytometry method. Results: Toxoplasma-positive sera reacted more strongly with both breast cancer cell lines than Toxoplasma-negative sera. Conclusions: Anti-T. gondii antibodies strongly react with breast cancer cells. These antibodies may be used for selective cancer immunotherapy in the future. © 2023, Author(s).
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