Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluating the Effects of Acarbose on Anthropometry Indexes and Metabolic Markers in Patients With Metabolic Syndrome in Comparison to Placebo, in Isfahan City, Iran Publisher



Khalili N1 ; Sheikhaboomasoudi A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, School of Medicine, Isfahan University of Medical Science, Iran

Source: Journal of Isfahan Medical School Published:2018


Abstract

Background: Metabolic syndrome (MTS) is a group of metabolic abnormalities that occur simultaneously. Acarbose is an anti-diabetes medication that studies showed its effects on improving lipid profile, blood sugar, insulin resistance, and weight loss. This study aimed to evaluate the effects of acarbose on anthropometry indexes and metabolic markers in patients with metabolic syndrome in comparison to placebo, in Isfahan City, Iran. Methods: This was a randomized clinical trial study on patients with metabolic syndrome who referred to Sedighe Tahere Research Institute. Patients were randomly divided into two groups treated with acarbose or placebo for 6 months. Before and after intervention, weight, waist circumference, and hip circumference were measured, and the level of fasting blood sugar, postprandial blood sugar (30 minutes, and 1 and 2 hours), cholesterol, triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), liver enzymes, albumin, C-reactive protein (CRP), insulin (fast, and 30 minutes, and 1 and 2 hours postprandial), and insulin resistance index (Homeostatic Model Assessment of Insulin Resistance or HOMA-IR) were evaluated and then compared. Findings: In this study, 74 patients with metabolic syndrome with mean age of 39.9 ± 8.5 years were evaluated, of them, 27.02% were men. The mean weight (P < 0.001), waist circumference (P < 0.001), hip circumference (P < 0.001), and 1-hour (P < 0.010) and 2-hour postprandial blood sugar (P < 0.001) decreased significantly in acarbose group, the mean level of HDL significantly increased (P = 0.020), and HOMA-IR significantly decreased (P = 0.020). Other variables did not show significant differences. Conclusion: Acarbose can reduce weight and abdominal obesity, and improve postprandial blood sugar level, HDL level, and insulin resistance status. © 2018, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. The Effect of “Moderately Restricted Carbohydrate” Diet on Gut Microbiota Composition and Metabolic Parameters in Women With Metabolic Syndrome: A Study Protocol for a Randomized Controlled Trial, Trials (2022)
2. First Nationwide Study of the Prevalence of the Metabolic Syndrome and Optimal Cutoff Points of Waist Circumference in the Middle East: The National Survey of Risk Factors for Noncommunicable Diseases of Iran, Diabetes Care (2009)
3. Lipid Accumulation Product and Visceral Adiposity Index for Incidence of Cardiovascular Diseases and Mortality; Results From 13 Years Follow-Up in Isfahan Cohort Study, Obesity Science and Practice (2024)
4. Effects of a Moderately-Restricted Carbohydrate Diet on Cardiovascular Risk Factors Among Women With Metabolic Syndrome, Journal of Isfahan Medical School (2012)
5. Determinants of Incident Metabolic Syndrome in a Middle Eastern Population: Isfahan Cohort Study, Metabolic Syndrome and Related Disorders (2017)
6. Sex Based Levels of C-Reactive Protein and White Blood Cell Count in Subjects With Metabolic Syndrome: Isfahan Healthy Heart Program, Journal of Research in Medical Sciences (2013)
7. Randomized Study of the Effects of Empagliflozin and Topiramate Dual Therapy on Anthropometric and Metabolic Indices in Non-Diabetic Individuals With Overweight/Obesity on a Calorie-Restricted Diet, Eating and Weight Disorders (2024)
8. Effects of Sodium-Glucose Co-Transporter-2 Inhibitors on Anthropometric Indices and Metabolic Markers in Overweight/Obese Individuals Without Diabetes: A Systematic Review and Meta-Analysis, Current Medical Research and Opinion (2022)
Experts (# of related papers)
View all Related Experts
Roya Kelishadi (68)
Nizal Sarrafzadegan (49)
Other Related Docs
9. The Relationship Between Diet Quality Index and Components of Metabolic Syndrome, Journal of Health System Research (2024)
10. Assessing Body Shape Index As a Risk Predictor for Cardiovascular Diseases and Metabolic Syndrome Among Iranian Adults, Nutrition (2014)
11. Correlation of Circulating Inflammatory Markers, Ghrelin, Adiponectin With Obesity Indices in Subjects With Metabolic Syndrome, Pakistan Journal of Medical Sciences (2013)
12. Alpha-Lipoic Acid Supplement in Obesity Treatment: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2018)
13. Low-Carbohydrate-Diet Score and Metabolic Syndrome: An Epidemiologic Study Among Iranian Women, Nutrition (2015)
14. Evaluating the Relation Between Metabolic Syndrome and Its Components With Low Ankle to Brachial Index in an Iranian Population, Journal of Isfahan Medical School (2011)
15. The Impact of a Community Trial on the Pharmacological Treatment in the Individuals With the Metabolic Syndrome: Findings From the Isfahan Healthy Heart Program, 2001-2007, Archives of Medical Science (2012)
16. Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?, Cholesterol (2013)
17. The Characteristics of Uterine Leiomyoma and Metabolic Syndrome in the Multiparous Overweight Women in Northern Iran, Pakistan Journal of Medical and Health Sciences (2020)
18. Assessing the Predictive Value of Insulin Resistance Indices for Metabolic Syndrome Risk in Type 2 Diabetes Mellitus Patients, Scientific Reports (2024)
19. Effects of Probiotic Supplementation on Anthropometric and Metabolic Characteristics in Adults With Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition (2021)
20. The Effect of Curcumin Pill in Treatment of Non-Alcoholic Fatty Liver Disease: A Clinical Trial Study, Journal of Isfahan Medical School (2017)
21. Association Between Serum Calcium and Metabolic Syndrome Indicators Among Women in Mazandaran, Northern Province of Iran, Malaysian Journal of Nutrition (2016)
22. Metabolic Syndrome and Associated Factors in Iranian Children and Adolescents: The Caspian-V Study, Journal of Cardiovascular and Thoracic Research (2018)
23. Association of Dietary Behaviors, Biochemical, and Lifestyle Factors With Metabolic Phenotypes of Obesity in Children and Adolescents, Diabetology and Metabolic Syndrome (2020)
24. Association of Dietary Insulin Index and Dietary Insulin Load With Metabolic Health Status in Iranian Overweight and Obese Adolescents, Frontiers in Nutrition (2022)
25. The Effect of a Moderately Restricted Carbohydrate Diet on Cardiometabolic Risk Factors in Overweight and Obese Women With Metabolic Syndrome: A Randomized Controlled Trial, Clinical Therapeutics (2023)
26. The Product of Triglycerides and Glucose in Comparison With Fasting Plasma Glucose Did Not Improve Diabetes Prediction, Acta Diabetologica (2015)
27. Dietary and Non-Dietary Determinants of Central Adiposity Among Tehrani Women, Public Health Nutrition (2008)
28. The Visceral Adiposity Index in Comparison With Easily Measurable Anthropometric Markers Did Not Improve Prediction of Diabetes, Canadian Journal of Diabetes (2016)
29. The Characteristics of Pre-Diabetic Patients Associated With Body Composition and Cardiovascular Disease Risk Factors in the Iranian Population, Journal of Research in Medical Sciences (2016)
30. Effects of Modified-Paleo and Moderate-Carbohydrate Diets on Body Composition, Serum Levels of Hepatokines and Adipocytokines, and Flow Cytometric Analysis of Endothelial Microparticles in Adults With Metabolic Syndrome: A Study Protocol for a Randomized Clinical Trial, Trials (2021)
31. Correlation of Dyslipidemia With Waist to Height Ratio, Waist Circumference, and Body Mass Index in Iranian Adults, Asia Pacific Journal of Clinical Nutrition (2007)
32. Sugar-Sweetened Beverages Consumption and Long-Term Side Effects on Nutrition and Health Outcomes in Pediatric Age Group, Value-Added Ingredients and Enrichments of Beverages: Volume 14: The Science of Beverages (2019)
33. Associations Between Serum Ceruloplasmin Level, Obesity and Metabolic and Inflammatory Indexes, Journal of Isfahan Medical School (2012)
34. Association of Anthropometric Measures With Cardiovascular Risk Factors and Metabolic Syndrome in Normal-Weight Children and Adolescents: The Caspian Iii Study, Obesity Facts (2013)
35. Validity of Self-Reported Height, Weight, Body Mass Index, and Waist Circumference in Iranian Adults, International Journal of Preventive Medicine (2021)
36. Factors Associated With Insulin Resistance and Non-Alcoholic Fatty Liver Disease Among Youths, Atherosclerosis (2009)
37. A Personalised Diet Approach Study: Interaction Between Ppar-Γ Pro12ala and Dietary Insulin Indices on Metabolic Markers in Diabetic Patients, Journal of Human Nutrition and Dietetics (2022)
38. Association of Dietary Pattern and Metabolic Syndrome in 15- to 49-Years-Old Women, Journal of Isfahan Medical School (2015)
39. Is Any Association Between Alternate Healthy Eating Index (Ahei) With Lipid Profile and Liver Enzymes? a Cross-Sectional Study, Journal of Diabetes and Metabolic Disorders (2021)
40. Association Between Dietary Fat Quality Indices With Anthropometric Measurements in Children and Adolescents, BMC Pediatrics (2022)
41. Effect of Green Tea Consumption on the Metabolic Syndrome Indices in Women: A Clinical Trial Study, Nutrition and Food Science (2019)
42. Neck Circumference in Relation to Glycemic Parameters: A Systematic Review and Meta-Analysis of Observational Studies, Diabetology and Metabolic Syndrome (2019)
43. Changes in Serum Lipid Profile of Obese or Overweight Children and Adolescents Following a Lifestyle Modification Course, ARYA Atherosclerosis (2012)
44. The Association of Dietary Carbohydrate Quality and Quantity With Obesity Among Iranian Adolescents: A Case-Control Study, BMC Pediatrics (2024)
45. The Effect of Psyllium on Fasting Blood Sugar, Hba1c, Homa Ir, and Insulin Control: A Grade-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Endocrine Disorders (2024)
46. Evaluation of the Effects of Roselle (Hibiscus Sabdariffa L.) on Oxidative Stress and Serum Levels of Lipids, Insulin and Hs-Crp in Adult Patients With Metabolic Syndrome: A Double-Blind Placebo-Controlled Clinical Trial, Journal of Complementary and Integrative Medicine (2016)
47. Cholesterol Synthesis and Absorption Markers in Type 2 Diabetes Mellitus, Journal of Isfahan Medical School (2019)
48. The Effect of Green Coffee Extract Supplementation on Anthropometric Measures in Adults: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials, Complementary Therapies in Medicine (2020)
49. Dash Diet, Insulin Resistance, and Serum Hs-Crp in Polycystic Ovary Syndrome: A Randomized Controlled Clinical Trial, Hormone and Metabolic Research (2015)
50. Association of the Triglyceride Glucose Index With All-Cause and Cardiovascular Mortality in a General Population of Iranian Adults, Cardiovascular Diabetology (2024)