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The Effect of Glucomannan Supplementation on Lipid Profile in Adults: A Grade-Assessed Systematic Review and Meta-Analysis Publisher Pubmed



Musazadeh V1, 2 ; Rostami RY3 ; Moridpour AH4 ; Hosseini ZB5 ; Nikpayam O6 ; Falahatzadeh M7 ; Faghfouri AH8
Authors
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Authors Affiliations
  1. 1. Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Student Research Committee, Department of Nutritional Sciences, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
  6. 6. Department of Nutritional Sciences, School of Health, Golestan University of Medical Sciences, Gorgan, Iran
  7. 7. Department of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  8. 8. Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran

Source: BMC Cardiovascular Disorders Published:2024


Abstract

Background: Glucomannan has been studied for various health benefits, but its effects on lipid profile in adults are not well understood. This meta-analysis aims to evaluate the impact of glucomannan supplementation on serum/plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), Apo B1, Apo A1, APO-B/ A1 ratio, and LDL-C/ HDL-C in adults. Methods: A comprehensive search was conducted across Scopus, PubMed, Embase, and Web of Science from inception to June 2024 to identify randomized controlled trials (RCTs) assessing glucomannan supplementation on lipid profile in adults. Data were extracted and analyzed using random effects model to determine the standardized mean differences (SMDs) and 95% confidence intervals (CIs) for each biomarker. Results: Glucomannan supplementation significantly decreased TC (SMD: -3.299; 95% CI: -4.955, -1.664, P < 0.001; I2 = 95.41%, P-heterogeneity < 0.001), LDL-C (SMD: -2.993; 95% CI: -4.958, -1.028; P = 0.006; I2 = 95.49%, P-heterogeneity < 0.001), and Apo B1 (SMD: -2.2; 95% CI: -3.58, -0.82; P = 0.01). However, glucomannan did not alter the levels of TG (SMD: -0.119; 95% CI: -1.076, 0.837, P = 0.789; I2 = 91.63%, P-heterogeneity < 0.001), Apo A1 (SMD: -0.48; 95% CI: -6.27, 5.32; P = 0.76), APO-B/ A1 ratio (SMD: -1.15; 95% CI: -2.91, 0.61; P = 0.11), and LDL-C/ HDL-C ratio (SMD: -2.2; 95% CI: -7.28, 2.87; P = 0.2). Conclusions: Glucomannan supplementation has a beneficial effect on the level of TC and LDL-C. © The Author(s) 2024.
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