Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Crocin (Bioactive Compound of Crocus Sativus L.) Potently Restores Rem Sleep Deprivation-Induced Manic- and Obsessive-Compulsive-Like Behaviors in Female Rats Publisher Pubmed



Houshyar M1 ; Karimi H2 ; Ghofranijahromi Z3 ; Nouri S3 ; Vaseghi S3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Psychology, Faculty of Humanities, Persian Gulf University, Bushehr, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cognitive Neuroscience Lab, Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Iran
  4. 4. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran

Source: Behavioural Pharmacology Published:2024


Abstract

Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors including hyperlocomotion. On the other hand, crocin (one of the main compounds of Crocus sativus L. or Saffron) may be beneficial in the improvement of mental and cognitive dysfunctions. Also, crocin can restore the deleterious effects of SD on mental and cognitive processes. In this study, we investigated the effect of REM SD on female rats' behaviors including depression- and anxiety-like behaviors, locomotion, pain perception, and obsessive-compulsive-like behavior, and also, the potential effect of crocin on REM SD effects. We used female rats because evidence on the role of REM SD in modulating psychological and behavioral functions of female (but not male) rats is limited. REM SD was induced for 14 days (6h/day), and crocin (25, 50, and 75 mg/kg) was injected intraperitoneally. Open field test, forced swim test, hot plate test, and marble burying test were used to assess rats' behaviors. The results showed REM SD-induced manic-like behavior (hyperlocomotion). Also, REM SD rats showed decreased anxiety- and depression-like behavior, pain subthreshold (the duration it takes for the rat to feel pain), and showed obsessive compulsive-like behavior. However, crocin at all doses partially or fully reversed REM SD-induced behavioral changes. In conclusion, our results suggested the possible comorbidity of OCD and REM SD-induced manic-like behavior in female rats or the potential role of REM SD in the etiology of OCD, although more studies are needed. In contrast, crocin can be a possible therapeutic choice for decreasing manic-like behaviors. © 2024 Lippincott Williams and Wilkins. All rights reserved.
Related Docs
View other Related Docs
1. Chronic Rem Sleep Deprivation Leads to Manic- and Ocd-Related Behaviors, and Decreases Hippocampal Bdnf Expression in Female Rats, Psychopharmacology (2024)
2. Dose-Dependent Manner of Luteolin in the Modulation of Spatial Memory With Respect to the Hippocampal Level of Hsp70 and Hsp90 in Sleep-Deprived Rats, Gene (2023)
3. Do Sleep Disturbances Have a Dual Effect on Alzheimer’S Disease?, Cellular and Molecular Neurobiology (2023)
4. Crocin Has a Greater Therapeutic Role in the Restoration of Behavioral Impairments Caused by Maternal Social Isolation in Adolescent Than in Adult Offspring Probably Through Gsk-3Beta Downregulation, Learning and Motivation (2024)
5. The Interaction Effect of Sleep Deprivation and Treadmill Exercise in Various Durations on Spatial Memory With Respect to the Oxidative Status of Rats, Neurochemical Research (2023)
6. Different Protocols of Rem Sleep Deprivation Led to Controversial Effects on Ocd- and Anxiety-Like Behaviors and Locomotor Activity in Fear Conditioning Male and Female Rats With Respect to Bdnf Expression Level, Pharmacology Biochemistry and Behavior (2025)
7. Modulating Role of Serotonergic Signaling in Sleep and Memory, Pharmacological Reports (2022)
8. The Role of Sleep Deprivation in Streptozotocin-Induced Alzheimer’S Disease-Like Sporadic Dementia in Rats With Respect to the Serum Level of Oxidative and Inflammatory Markers, Experimental Brain Research (2022)
Experts (# of related papers)
View all Related Experts
Shahin Akhondzadeh Basti (3)
Seyed Abolghasem Mortazavi Machiani (1)
Other Related Docs
9. Intricate Role of Sleep Deprivation in Modulating Depression: Focusing on Bdnf, Vegf, Serotonin, Cortisol, and Tnf-Α, Metabolic Brain Disease (2023)
10. Night Shift Hormone: How Does Melatonin Affect Depression?, Physiology and Behavior (2022)
11. Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal With Respect to the Hippocampal Level of Glun1, Glun2a, and Glun2b, Journal of Molecular Neuroscience (2022)
12. Cannabinoids and Sleep-Wake Cycle: The Potential Role of Serotonin, Behavioural Brain Research (2021)
13. The Effect of Alpha-2 Adrenergic Receptors on Memory Retention Deficit Induced by Rapid Eye Movement Sleep Deprivation, Iranian Journal of Basic Medical Sciences (2020)
14. The Effect of Alpha Lipoic Acid on Passive Avoidance and Social Interaction Memory, Pain Perception, and Locomotor Activity in Rem Sleep-Deprived Rats, Pharmacological Reports (2021)
15. A Comprehensive Literature Review on the Effects of Saffron and Its Bioactive Components on Traumatic Brain Injury (Tbi), Naunyn-Schmiedeberg's Archives of Pharmacology (2025)
16. Evaluating Efficacy and Safety of Saffron Add-On Treatment in Improvement of Motor and Depressive Symptoms of Patients With Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Journal of Herbal Medicine (2024)
17. Oral Supplementation With Crocin (A Constituent of Saffron) in Subjects With Cigarette Smoking: A Clinical Trial, Naunyn-Schmiedeberg's Archives of Pharmacology (2024)
18. Saffron As a Promising Therapy for Diabetes and Alzheimer's Disease: Mechanistic Insights, Metabolic Brain Disease (2023)
19. Prospects of Saffron and Its Derivatives in Alzheimer's Disease, Archives of Iranian Medicine (2021)
20. Novel Neuroprotective Potential of Crocin in Neurodegenerative Disorders: An Illustrated Mechanistic Review, Neurochemical Research (2020)
21. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)