Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy Publisher Pubmed



Rezaei G^{1, 2} ; Daghighi SM³ ; Haririan I^{1, 4} ; Yousefi I⁵ ; Raoufi M² ; Rezaee F^{6, 7} ; Dinarvand R^{2, 8}
Source: Colloids and Surfaces B: Biointerfaces Published:2019

Abstract

Bio-nano interface investigation models are mainly based on the type of proteins present on corona, bio-nano interaction responses and the evaluation of final outcomes. Due to the extensive diversity in correlative models for investigation of nanoparticles biological responses, a comprehensive model considering different aspects of bio-nano interface from nanoparticles properties to protein corona fingerprints appeared to be essential and cannot be ignored. In order to minimize divergence in studies in the era of bio-nano interface and protein corona with following therapeutic implications, a useful investigation model on the basis of RADAR concept is suggested. The contents of RADAR concept consist of five modules: 1- Reshape of our strategy for synthesis of nanoparticles (NPs), 2- Application of NPs selected based on human fluid, 3- Delivery strategy of NPs selected based on target tissue, 4- Analysis of proteins present on corona using correct procedures and 5- Risk assessment and risk reduction upon the collection and analysis of results to increase drug delivery efficiency and drug efficacy. RADAR grouping strategy for revisiting protein corona phenomenon as a key of success will be discussed with respect to the current state of knowledge. © 2019 Elsevier B.V.